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Identifier: 15678187

GI number: 15678187

Start: 105379

End: 106059

Strand: Direct

Name: Not Available

Synonym: MTH159

Alternate gene names: 15678187

Gene position: 105379-106059 (Clockwise)

Preceding gene: 15678186

Following gene: 15678188

Centisome position: 6.02

GC content: 53.45

Gene sequence:

>681_bases
ATGGGGGAGAAGGTATACGAACTCAGAAAGATAAAGAAAAAGGGAAGGGGAATGCCCCTCATAGGGGATAAATTCCCGGA
GATGGAGGTCCAGACGACCCATGGACCGATGGAACTCCCGGATGAATTTGAGGGCAAATGGTTCATCCTCTTCAGCCACC
CTGCAGACTTCACACCGGTCTGCACAACGGAGTTCGTGGCCTTTCAGGAGGTATACCCGGAACTCCGGGAACTTGACTGT
GAACTCGTGGGCCTCAGTGTTGACCAGGTATTCTCCCACATCAAGTGGATCGAGTGGATAGCCGAGAACCTTGACACAGA
GATAGAGTTCCCGGTGATAGCAGATACCGGACGGGTGGCGGACACCCTGGGACTCATCCACCCGGCAAGACCCACAAACA
CCGTCAGGGCAGTCTTTGTGGTGGACCCGGAGGGGATAATAAGGGCCATCCTATACTATCCACAGGAACTTGGAAGGAAC
ATCCCGGAAATCGTGAGGATGATACGTGCCTTCAGGGTCATAGATGCTGAGGGGGTTGCAGCACCAGCCAACTGGCCCGA
TAACCAGCTCATCGGTGACCATGTGATAGTGCCTCCCGCATCTGATATTGAAACCGCGAGAAAGAGGAAGGATGAATATG
AATGCTATGACTGGTGGCTATGCACCCAAAGTAGGGGGTGA

Upstream 100 bases:

>100_bases
GGTGCGCCTCGCATCAGACTCACCCAGCGGACTCCTCATGCTGGATGCAGAACTGGCAAAGAGGGTCTACAATCCACCCG
CAGATAAGGGGGAATGAGCT

Downstream 100 bases:

>100_bases
ATGATTTGGAGAAAAAATTCTATGAGCTACCTGAGCTCCCGTACCCATACGACGCCCTTGAACCACACATATCCCGGGAG
CAGCTCACCATACACCACCA

Product: alkyl hydroperoxide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MGEKVYELRKIKKKGRGMPLIGDKFPEMEVQTTHGPMELPDEFEGKWFILFSHPADFTPVCTTEFVAFQEVYPELRELDC
ELVGLSVDQVFSHIKWIEWIAENLDTEIEFPVIADTGRVADTLGLIHPARPTNTVRAVFVVDPEGIIRAILYYPQELGRN
IPEIVRMIRAFRVIDAEGVAAPANWPDNQLIGDHVIVPPASDIETARKRKDEYECYDWWLCTQSRG

Sequences:

>Translated_226_residues
MGEKVYELRKIKKKGRGMPLIGDKFPEMEVQTTHGPMELPDEFEGKWFILFSHPADFTPVCTTEFVAFQEVYPELRELDC
ELVGLSVDQVFSHIKWIEWIAENLDTEIEFPVIADTGRVADTLGLIHPARPTNTVRAVFVVDPEGIIRAILYYPQELGRN
IPEIVRMIRAFRVIDAEGVAAPANWPDNQLIGDHVIVPPASDIETARKRKDEYECYDWWLCTQSRG
>Mature_225_residues
GEKVYELRKIKKKGRGMPLIGDKFPEMEVQTTHGPMELPDEFEGKWFILFSHPADFTPVCTTEFVAFQEVYPELRELDCE
LVGLSVDQVFSHIKWIEWIAENLDTEIEFPVIADTGRVADTLGLIHPARPTNTVRAVFVVDPEGIIRAILYYPQELGRNI
PEIVRMIRAFRVIDAEGVAAPANWPDNQLIGDHVIVPPASDIETARKRKDEYECYDWWLCTQSRG

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=202, Percent_Identity=36.6336633663366, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI5802974, Length=186, Percent_Identity=30.6451612903226, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI32483377, Length=186, Percent_Identity=30.6451612903226, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI32189392, Length=146, Percent_Identity=34.2465753424658, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4505591, Length=146, Percent_Identity=32.1917808219178, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI32455266, Length=146, Percent_Identity=32.1917808219178, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI32455264, Length=146, Percent_Identity=32.1917808219178, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=29.8429319371728, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI33188454, Length=58, Percent_Identity=44.8275862068966, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786822, Length=148, Percent_Identity=32.4324324324324, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25153706, Length=192, Percent_Identity=33.8541666666667, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17554494, Length=150, Percent_Identity=31.3333333333333, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193204376, Length=146, Percent_Identity=31.5068493150685, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32565831, Length=146, Percent_Identity=31.5068493150685, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319407, Length=215, Percent_Identity=38.1395348837209, Blast_Score=141, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323613, Length=146, Percent_Identity=30.8219178082192, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320661, Length=146, Percent_Identity=26.7123287671233, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652436, Length=197, Percent_Identity=34.010152284264, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24652434, Length=198, Percent_Identity=34.8484848484849, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24581278, Length=172, Percent_Identity=38.3720930232558, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17975518, Length=198, Percent_Identity=34.3434343434343, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17738015, Length=175, Percent_Identity=29.7142857142857, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI17157991, Length=150, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24641739, Length=150, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656348, Length=147, Percent_Identity=30.6122448979592, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17864676, Length=147, Percent_Identity=30.6122448979592, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=33.5616438356164, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 25887; Mature: 25756

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKVYELRKIKKKGRGMPLIGDKFPEMEVQTTHGPMELPDEFEGKWFILFSHPADFTPV
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCC
CTTEFVAFQEVYPELRELDCELVGLSVDQVFSHIKWIEWIAENLDTEIEFPVIADTGRVA
HHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCEECEEEECCCCHH
DTLGLIHPARPTNTVRAVFVVDPEGIIRAILYYPQELGRNIPEIVRMIRAFRVIDAEGVA
HHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHCCCCCCC
APANWPDNQLIGDHVIVPPASDIETARKRKDEYECYDWWLCTQSRG
CCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCC
>Mature Secondary Structure 
GEKVYELRKIKKKGRGMPLIGDKFPEMEVQTTHGPMELPDEFEGKWFILFSHPADFTPV
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCC
CTTEFVAFQEVYPELRELDCELVGLSVDQVFSHIKWIEWIAENLDTEIEFPVIADTGRVA
HHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCEECEEEECCCCHH
DTLGLIHPARPTNTVRAVFVVDPEGIIRAILYYPQELGRNIPEIVRMIRAFRVIDAEGVA
HHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHCCCCCCC
APANWPDNQLIGDHVIVPPASDIETARKRKDEYECYDWWLCTQSRG
CCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7781971 [H]