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Identifier: 15678081

GI number: 15678081

Start: 31459

End: 32691

Strand: Direct

Name: Not Available

Synonym: MTH52

Alternate gene names: 15678081

Gene position: 31459-32691 (Clockwise)

Preceding gene: 15678080

Following gene: 15678113

Centisome position: 1.8

GC content: 53.12

Gene sequence:

>1233_bases
ATGGTGACTGTAAACGAGAACTACCTGCTACTTAAAAGCAGCTACATATTCTCCGAGATAAACAGGAGAGTTGAGGAATT
CCAGAGAAAAAATCCTGACGCTGACATAATCAGGATGGGTATAGGTGATGTGACAAGGCCCCTCCCGGAGGCAGTTGTTG
AGGCCTTCCACAGGGCCGTTGATGAGATGGCAGAGGAGGAGACATTCAGGGGCTACGGACCGGAACAGGGATACCCCTTC
CTCAGGGAGGCCATAGCAGAGAACGACTACGCTTCAAGGGGAGTTGATATCACAGCAGATGAGATCTTCATAAGCGACGG
TGCCAAGTGCGACACAGGAAACATCCAGGAGATCTTTGGACTCGACAACGTTGTCGCTGTCACAGACCCTGTCTACCCTG
TTTACGTTGAGAGCAACGTCATGGCAGGACGTGCCGGCCCGGCAGACGACGATGGAAGATACAGTGGACTTGTCTACCTC
CCATGTACAGAGGAGAACAGCTTCATACCCTCCCTCCCAGAGGAGAGGGTGGACCTCATCTACCTCTGCTACCCCAACAA
CCCCACAGGAACAACACTGACAGAGAAACAGCTTGCTGAGTGGGTGGACTATGCAAGGGACAGTGGCAGCTTGATACTCT
TCGATGCAGCCTACGAGGCCTACATCCAGGAGGATGGGATACCCCACAGCATCTACGAAGTCGAAGGTGCAAGGGAAGTC
GCGATTGAGTTCAGGAGCTTCTCAAAGAACGCGGGCTTCACAGGTACAAGGTGTGCCTTCACGGTTGTACCTGAAGAACT
TGAGGTCCCTGACAGCAGCGGAAGGATGCACTCTGTGAGGGAACTCTGGAACAGGCGCCAGACAACAAAGTTCAACGGAG
TCTCCTACCCGGTCCAGAGGGCGGCCGAGGCTGTCTACACACCTGAGGGGCAGCGGGAGATAAGGGAATCCATTGATTAC
TACATGGAAAACGCCAGGATAATAAGGGAAAGCCTTGAAAGGGCAGGTTTAAGGTACTATGGTGGTGTAAACGCACCATA
CATCTGGATAAGGACGCCCGAGGGAATGGACTCCTGGCAGTTCTTTGACACCCTCCTCAATGATGCTGAGGTCGTTGGGA
CACCGGGCTCAGGTTTCGGACCAAGTGGTGAGGGTTACTTCCGTCTCACAGCCTTCAACTCCTTCAGGAACACTGTGAAG
GCCATGGAGAGGATATCAGAGCTGAGCTTCTAG

Upstream 100 bases:

>100_bases
TCACAGGCTGGGGATTCAGCACAGCAATTTTTATTAACTCCAGTGGACTACATGATAATATCATTCTTCTCGTGTTGAAT
TAACTTCTGGAGGATAAATC

Downstream 100 bases:

>100_bases
ATGATACTGATTGTTGATGGTAGAGCAGTCACCATCACGGAAAAATAAATAATTAATTTTTTAATTCATGGCTGAGTTTA
TTGCCATATATGCGACACTG

Product: L,L-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRAVDEMAEEETFRGYGPEQGYPF
LREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIFGLDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYL
PCTEENSFIPSLPEERVDLIYLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGAREV
AIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQRAAEAVYTPEGQREIRESIDY
YMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSWQFFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVK
AMERISELSF

Sequences:

>Translated_410_residues
MVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRAVDEMAEEETFRGYGPEQGYPF
LREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIFGLDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYL
PCTEENSFIPSLPEERVDLIYLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGAREV
AIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQRAAEAVYTPEGQREIRESIDY
YMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSWQFFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVK
AMERISELSF
>Mature_410_residues
MVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRAVDEMAEEETFRGYGPEQGYPF
LREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIFGLDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYL
PCTEENSFIPSLPEERVDLIYLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGAREV
AIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQRAAEAVYTPEGQREIRESIDY
YMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSWQFFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVK
AMERISELSF

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788722, Length=387, Percent_Identity=25.8397932816537, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788627, Length=251, Percent_Identity=25.4980079681275, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_METTH (O26158)

Other databases:

- EMBL:   AE000666
- PIR:   E69168
- RefSeq:   NP_275195.1
- ProteinModelPortal:   O26158
- SMR:   O26158
- STRING:   O26158
- GeneID:   1470014
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH52
- NMPDR:   fig|187420.1.peg.50
- eggNOG:   arNOG05001
- HOGENOM:   HBG645860
- OMA:   VDLIYLC
- ProtClustDB:   PRK07590
- BioCyc:   MTHE187420:MTH52-MONOMER
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR019942
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03542

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 46214; Mature: 46214

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 42-42 BINDING 72-72 BINDING 75-75 BINDING 109-109 BINDING 132-132 BINDING 187-187 BINDING 187-187 BINDING 215-215 BINDING 218-218 BINDING 246-246 BINDING 248-248 BINDING 257-257 BINDING 292-292 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRAV
CEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHHHHHHH
DEMAEEETFRGYGPEQGYPFLREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIFG
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHCCCCEEEEEEEECCCCCCCCCCHHHHHC
LDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYLPCTEENSFIPSLPEERVDLI
CCCEEEEECCCEEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEE
YLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGAREV
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCHHEECCCCHHH
AIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQR
HHHHHHCCCCCCCCCCCEEEEECCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHH
AAEAVYTPEGQREIRESIDYYMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSWQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHH
FFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVKAMERISELSF
HHHHHHCCCEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRAV
CEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHHHHHHH
DEMAEEETFRGYGPEQGYPFLREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIFG
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHCCCCEEEEEEEECCCCCCCCCCHHHHHC
LDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYLPCTEENSFIPSLPEERVDLI
CCCEEEEECCCEEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEE
YLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGAREV
EEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCHHEECCCCHHH
AIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQR
HHHHHHCCCCCCCCCCCEEEEECCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHH
AAEAVYTPEGQREIRESIDYYMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSWQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHH
FFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVKAMERISELSF
HHHHHHCCCEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463