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Identifier: 15678075

GI number: 15678075

Start: 24423

End: 25334

Strand: Direct

Name: Not Available

Synonym: MTH46

Alternate gene names: 15678075

Gene position: 24423-25334 (Clockwise)

Preceding gene: 15678074

Following gene: 15678076

Centisome position: 1.39

GC content: 56.36

Gene sequence:

>912_bases
TTGAAGTCGTCGGCATCCGCACCTGCCAAGGCCATTCTTTTTGGTGAACACGCAGTGGTCTACAGCAAGCCGGCAATAGC
AGCCGCCATAGACCGCAGGGTGACTGTAACCGTAAGTGAATCCAGCAGCACCCATGTAACCATCCCCTCCCTGGGTATAC
GCCACAGTTCAGAGAGACCATCCGGTGGCATCCTGGACTACATCGGGAGGTGCCTCGAGCTTTACCATGACGCATCACCC
CTTGACATCAGGGTGGAGATGGAGATACCCGCCGGTTCAGGCCTAGGTTCATCGGCTGCACTCACCGTTGCACTGATAGG
TCCCCTCGACAGGTACCATGGAAGGGATCATGGACCCGGGGAGACAGCAGCCAGGGCCCACAGGGTGGAGGTTGATGTAC
AGGGAGCCGCCAGCCCCCTTGACACAGCCATCAGCACCTATGGGGGCCTTGTATACCTTGACAGCCAGAGGAGGGTGAGG
CAGTTTGAGGCCGACCTGGGGGACCTTGTAATAGCACACCTTGACTATTCAGGGGAAACAGCCAGGATGGTTGCCGGCGT
AGCTGAAAGGTTCAGGAGATTCCCGGATATCATGGGGAGGATAATGGACACAGTTGAGTCCATAACCAATACAGCATACA
GGGAACTTCTAAGGAACAACACAGAACCCCTGGGGGAGCTCATGAACCTCAACCAGGGGCTGCTGGACTCCATGGGCGTT
TCCACACGTGAACTTTCAATGATGGTCTATGAGGCAAGGAACGCCGGGGCAGCAGGTTCAAAGATCACAGGAGCCGGCGG
CGGCGGGAGCATAATAGCCCACTGCCCGGGATGTGTGGATGATGTTGTCACGGCCCTTAACAGGAACTGGAAAGCCATGA
GGGCAGAGTTTTCGGTTAAGGGACTCATCTAA

Upstream 100 bases:

>100_bases
AGAATGCGACCTACTGAGATATGCAACAAGTGGAGATGTTACCGGTGACCGCAGCTCGGTGGTGGGCTACGCTCACTTGT
CCTGAGATAAGGGTGAAACA

Downstream 100 bases:

>100_bases
TATTCACAGGGTGCATATGTAATGATCATTCTCAAGCTTGGTGGAAGTGTAATTACCAGGAAGGACTCTGAGGAACCTGC
AATAGACAGGGATAACCTTG

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKSSASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTIPSLGIRHSSERPSGGILDYIGRCLELYHDASP
LDIRVEMEIPAGSGLGSSAALTVALIGPLDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVR
QFEADLGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEPLGELMNLNQGLLDSMGV
STRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVDDVVTALNRNWKAMRAEFSVKGLI

Sequences:

>Translated_303_residues
MKSSASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTIPSLGIRHSSERPSGGILDYIGRCLELYHDASP
LDIRVEMEIPAGSGLGSSAALTVALIGPLDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVR
QFEADLGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEPLGELMNLNQGLLDSMGV
STRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVDDVVTALNRNWKAMRAEFSVKGLI
>Mature_303_residues
MKSSASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTIPSLGIRHSSERPSGGILDYIGRCLELYHDASP
LDIRVEMEIPAGSGLGSSAALTVALIGPLDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVR
QFEADLGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEPLGELMNLNQGLLDSMGV
STRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVDDVVTALNRNWKAMRAEFSVKGLI

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=327, Percent_Identity=25.0764525993884, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4557769, Length=327, Percent_Identity=25.0764525993884, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32251; Mature: 32251

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTIPSLGIRHSSERP
CCCCCCCCCEEEEECCEEEEEECCHHHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCC
SGGILDYIGRCLELYHDASPLDIRVEMEIPAGSGLGSSAALTVALIGPLDRYHGRDHGPG
CCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEECCHHHHCCCCCCCC
ETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVRQFEADLGDLVIAHLDYSGET
HHHHHHEEEEEEECCCCCHHHHHHHHCCCEEEECCHHHHHHHHCCHHHEEEEEECCCCCH
ARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEPLGELMNLNQGLLDSMGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCC
STRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVDDVVTALNRNWKAMRAEFSVK
CHHHHHHHEEECCCCCCCCCCEECCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHCCEEC
GLI
CCC
>Mature Secondary Structure
MKSSASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTIPSLGIRHSSERP
CCCCCCCCCEEEEECCEEEEEECCHHHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCC
SGGILDYIGRCLELYHDASPLDIRVEMEIPAGSGLGSSAALTVALIGPLDRYHGRDHGPG
CCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEECCHHHHCCCCCCCC
ETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVRQFEADLGDLVIAHLDYSGET
HHHHHHEEEEEEECCCCCHHHHHHHHCCCEEEECCHHHHHHHHCCHHHEEEEEECCCCCH
ARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEPLGELMNLNQGLLDSMGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCC
STRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVDDVVTALNRNWKAMRAEFSVK
CHHHHHHHEEECCCCCCCCCCEECCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHCCEEC
GLI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]