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The map label for this gene is rnhA

Identifier: 15674239

GI number: 15674239

Start: 2349438

End: 2350316

Strand: Direct

Name: rnhA

Synonym: L132875

Alternate gene names: 15674239

Gene position: 2349438-2350316 (Clockwise)

Preceding gene: 15674238

Following gene: 15674240

Centisome position: 99.32

GC content: 34.36

Gene sequence:

>879_bases
ATGAATATTGTTCTAAAATTAGAGACTAAAGAACGCCAACAGCTCGCTGAGAAATACAAATCCTATGAGCAAGTTTCCAA
AAATCCTTACATCACTTTTTTTGCCAAGGTTGGGAAAACTTCTATCTCGGTTTATACTTCTGGAAAAGTTGTTTTTCAAG
GAAACGAGGCTGAAAAATTAGCGAGTGACTTTGGTCATATTGCTCAAGTCGTTCCTCAAAAACAAACAAATCTTATTGGG
ACTGACGAGGTGGGCAACGGGTCATATTTTGGTGGTTTAATGGTTACTGCTAGTTTTGTCAGTGAAGAAAACTTGAATTT
TCTAAAGGAAATTGGAGTCGCCGATTCTAAAAAATTAACTGACGAAAAAATTTGTCAAATTGCTCCAAAATTGATTGATA
GAATTCCACATGTTGCTTTAGTGGTTGAACCTGCCAAGTATAATGAGGTGATTGCTTCTGGTTATAACGCTGTAAGCATT
AAAGTTGCTCTCCATAATCAAGCCATTTATCTTCTTGAAAAACAATTAGGTCATAAGCCTGAAAATATTGTTATTGATGC
TTTCACAACGGAAGCAAATTATAAAAAATATGTTAATAAAGAGCAAAATCATCCGCTGACAAAGGTAACTTTACTGACAA
AAGCTGAAGATCAGTTTCTGGCTGTTGCTGTCAGTTCAATTATTTCTCGTTATCTTTTTTTAGAAAATCTAAAAAAATTA
TCTAAAGAATCAGGTTTCACGTTACCCAGTGGAGCAGGAAATTTATCTGACAAAATTGCAGCACAAATTATCAAAAGTCA
GGGAGTTGATGCTCTGAATCAGTTAGCAAAACTTCATTTTGCTAATACACAAAAAGCGATTAAAATCGCTCAATTATAG

Upstream 100 bases:

>100_bases
TTTACAACATGTTTGCTATAATAGATTCTAATAAGAAATTATTTTTAATAAATGGTCGGATTCTTATTCTAGAATAGCTA
ATTTATGGTAGAATGTTCTT

Downstream 100 bases:

>100_bases
AAAGTAAAATTATGATGAAATTTTTAAAAGAGTGGGGATTATTTCTCTTTATAATTATCGCTATTCTTCTCTCACTTGTC
TTTCTTTGGTCACTTGTTGT

Product: ribonuclease HIII

Products: NA

Alternate protein names: RNase HIII

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNIVLKLETKERQQLAEKYKSYEQVSKNPYITFFAKVGKTSISVYTSGKVVFQGNEAEKLASDFGHIAQVVPQKQTNLIG
TDEVGNGSYFGGLMVTASFVSEENLNFLKEIGVADSKKLTDEKICQIAPKLIDRIPHVALVVEPAKYNEVIASGYNAVSI
KVALHNQAIYLLEKQLGHKPENIVIDAFTTEANYKKYVNKEQNHPLTKVTLLTKAEDQFLAVAVSSIISRYLFLENLKKL
SKESGFTLPSGAGNLSDKIAAQIIKSQGVDALNQLAKLHFANTQKAIKIAQL

Sequences:

>Translated_292_residues
MNIVLKLETKERQQLAEKYKSYEQVSKNPYITFFAKVGKTSISVYTSGKVVFQGNEAEKLASDFGHIAQVVPQKQTNLIG
TDEVGNGSYFGGLMVTASFVSEENLNFLKEIGVADSKKLTDEKICQIAPKLIDRIPHVALVVEPAKYNEVIASGYNAVSI
KVALHNQAIYLLEKQLGHKPENIVIDAFTTEANYKKYVNKEQNHPLTKVTLLTKAEDQFLAVAVSSIISRYLFLENLKKL
SKESGFTLPSGAGNLSDKIAAQIIKSQGVDALNQLAKLHFANTQKAIKIAQL
>Mature_292_residues
MNIVLKLETKERQQLAEKYKSYEQVSKNPYITFFAKVGKTSISVYTSGKVVFQGNEAEKLASDFGHIAQVVPQKQTNLIG
TDEVGNGSYFGGLMVTASFVSEENLNFLKEIGVADSKKLTDEKICQIAPKLIDRIPHVALVVEPAKYNEVIASGYNAVSI
KVALHNQAIYLLEKQLGHKPENIVIDAFTTEANYKKYVNKEQNHPLTKVTLLTKAEDQFLAVAVSSIISRYLFLENLKKL
SKESGFTLPSGAGNLSDKIAAQIIKSQGVDALNQLAKLHFANTQKAIKIAQL

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG1039

COG function: function code L; Ribonuclease HIII

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase HII family. RnhC subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH3_LACLA (Q9CDG3)

Other databases:

- EMBL:   AE005176
- PIR:   A86907
- RefSeq:   NP_268414.1
- ProteinModelPortal:   Q9CDG3
- GeneID:   1115935
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L132875
- NMPDR:   fig|272623.1.peg.2312
- HOGENOM:   HBG288559
- OMA:   ASIIARY
- ProtClustDB:   PRK00996
- BioCyc:   LLAC272623:L132875-MONOMER
- BRENDA:   3.1.26.4
- GO:   GO:0005737
- HAMAP:   MF_00053
- InterPro:   IPR001352
- InterPro:   IPR004641
- InterPro:   IPR012337
- PIRSF:   PIRSF037748
- TIGRFAMs:   TIGR00716

Pfam domain/function: PF01351 RNase_HII; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 32205; Mature: 32205

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVLKLETKERQQLAEKYKSYEQVSKNPYITFFAKVGKTSISVYTSGKVVFQGNEAEKL
CCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCEEEEECCCHHHH
ASDFGHIAQVVPQKQTNLIGTDEVGNGSYFGGLMVTASFVSEENLNFLKEIGVADSKKLT
HHHHHHHHHHCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
DEKICQIAPKLIDRIPHVALVVEPAKYNEVIASGYNAVSIKVALHNQAIYLLEKQLGHKP
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCEEEEEEEECCCCCEEEHHHHCCCC
ENIVIDAFTTEANYKKYVNKEQNHPLTKVTLLTKAEDQFLAVAVSSIISRYLFLENLKKL
CCEEEEEEECCCHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SKESGFTLPSGAGNLSDKIAAQIIKSQGVDALNQLAKLHFANTQKAIKIAQL
HHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHEEEECC
>Mature Secondary Structure
MNIVLKLETKERQQLAEKYKSYEQVSKNPYITFFAKVGKTSISVYTSGKVVFQGNEAEKL
CCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCEEEEECCCHHHH
ASDFGHIAQVVPQKQTNLIGTDEVGNGSYFGGLMVTASFVSEENLNFLKEIGVADSKKLT
HHHHHHHHHHCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
DEKICQIAPKLIDRIPHVALVVEPAKYNEVIASGYNAVSIKVALHNQAIYLLEKQLGHKP
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCEEEEEEEECCCCCEEEHHHHCCCC
ENIVIDAFTTEANYKKYVNKEQNHPLTKVTLLTKAEDQFLAVAVSSIISRYLFLENLKKL
CCEEEEEEECCCHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SKESGFTLPSGAGNLSDKIAAQIIKSQGVDALNQLAKLHFANTQKAIKIAQL
HHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471