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The map label for this gene is mutL

Identifier: 15674190

GI number: 15674190

Start: 2290256

End: 2292343

Strand: Reverse

Name: mutL

Synonym: L0276

Alternate gene names: 15674190

Gene position: 2292343-2290256 (Counterclockwise)

Preceding gene: 15674191

Following gene: 15674189

Centisome position: 96.9

GC content: 36.16

Gene sequence:

>2088_bases
ATGATAGACAATTTTCATCTTGTCTATCATTTTTTGTCAGTAAAAAATGAAAAGCGAGCCCTTGCTTTTTGTGTTATAAT
TAGAATTAATTTAAAAAAACAAGAGAGCGAGATTATTGTGGGAAAAATTATTGAACTAAATGAAGCGCTCGCCAATCAAA
TTGCTGCTGGAGAGGTGGTTGAGCGGCCTGCTAGTGTTGTCAAAGAATTAGTCGAAAACTCAATTGATGCTGGAAGCAGT
AAAATTATTATCAATGTTGAAGAAGCTGGTTTGCGGTTAATTGAAGTCATTGATAATGGTTTGGGTTTGGAAAAAGAAGA
TGTGGCTTTGGCTTTACGTCGTCATGCAACAAGTAAAATCAAGGATTCGGCAGATTTGTTTCGGATTAGAACACTTGGTT
TTCGGGGGGAGGCTCTGCCATCAATCGCTTCTGTCAGCCAGATGACCATTGAAACAAGTACGGCTGAGGAAGAATCAGGA
ACAAAACTAGTTGCTAAAGGTGGAAATATCGAAACTTTAGAACCACTTGCTAAGCGAGTGGGGACGAAAATTTCTGTTGC
TAATCTTTTTTATAATACACCAGCAAGACTCAAGTATATCAAGTCCTTGCAGGCTGAACTTTCTCATATCACAGACATCA
TCAACCGATTGAGTCTGGCTCATCCAGAGATTTCCTTTACTTTAGTTAATGAGGGTAAAGAATTTTTGAAAACGGCTGGA
AATGGTGATTTACGCCAGGTTATTGCTGCAATTTATGGCATAGGGACAGCGAAAAAAATGCGTCAAATCAAGGGCTCAGA
CTTAGATTTTGAACTAACAGGTTATGTCAGCTTACCAGAGCTGACAAGGGCTAATCGTAATTATATTACGATTTTAATAA
ATGGTCGATTTATCAAAAACTTTTTATTGAATCGGGCAATTTTAGAAGGATATGGCAATCGATTGATGGTGGGACGGTTC
CCTTTTGCTATTTTATCGATTAAAATTGACCCAACACTTGCTGATGTTAATGTTCATCCGACAAAACAAGAGGTGCGTTT
GTCTAAAGAGCGTGAATTGATGGCTTTAATTTCTAAAGCAATTGATGAAGCTTTATCAGAAGGTGTTTTGATTCCAGAAG
CTTTGGAAAATTTGCAAGGAAGAGCTAAAGAAAAGGAGAGTCTTTCTGTTCAAACGGAACTTCCTTTGCAAAATAATCCT
TTATATTATGATAATGTTCGCCAAGATTTTTATGTCAGAGAAGAGGCAACTTTTAAAATCAATAAAAATCAAGCTTCAAA
TGATTCGTCTGAACAAACTTTTGATAATTTTACAGAAAATCAACTTAATACAGATGCTGTCAGTGAAAAAATGACTGACA
GAACTGTTGAAAGTACTACTGAAATTACTGACAACAGTCTAGAAAATACTGTCAGCAACTTTGAAATTGATTTTGATAAT
GAAGCAAAGATAAGTCAGTCATCAACTTTTCCGCAGCTTGAATACTTGGCACAATTGCATGCGACTTATTTACTTTGTCA
GTCCAAAGAAGGACTTTATTTGGTTGACCAACATGCGGCTCAAGAGCGAATAAAATATGAGTATTGGAAAGATAAAATTG
GTGAGGTCAGTATGGAGCAACAAATTTTACTTGCACCATATTTGTTCACTTTAGCCAAAAATGATTTTATTGTTTTAGCC
GAGAAGAAAGATTTGTTGCATGAAGCCGGTGTTTTCTTAGAAGAATACGGAGAAAATCAATTCATTTTAAGAGAACATCC
AATCTGGTTAAAAGAAACCGAGATAGAGAAATCAATTAATGAAATGATTGATATTATTCTCTCATCAAAAGAATTTTCAC
TCAAAAAATATCGTCATGATTTAGCTGCAATGGTTGCTTGTAAAAGTTCAATTAAAGCTAATCATCCCCTTGACGCCGAG
TCAGCTAGAGCTTTACTCGCAGAATTAGCAACTTGTAAAAATCCTTATAGTTGTGCGCATGGACGGCCAACGATTGTTCA
TTTTTCAGGGGATGACATTCAAAAAATGTTCCGGAGAATCCAAGAAACGCATCGTTCAAAAGCAGCTTCGTGGAAAGATT
TTGAGTAA

Upstream 100 bases:

>100_bases
CAATTTTGATTCTTATTTTCGTATTAGTCTTTGCTTTTAACAGCTATAATAATTTTGATAATGGTTACCGCGATTTTGGA
AACTACTAATTAATGTAAAA

Downstream 100 bases:

>100_bases
AAAGTGACTAAACAGATTAATGATGAAGTTGGTCAGTAAAAAAATAGATAAAAACTACTGACAGACTTGAATAAGGGAGT
TTGTCAATCAAAAAAATTAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MIDNFHLVYHFLSVKNEKRALAFCVIIRINLKKQESEIIVGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSS
KIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESG
TKLVAKGGNIETLEPLAKRVGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAG
NGDLRQVIAAIYGIGTAKKMRQIKGSDLDFELTGYVSLPELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRF
PFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEALSEGVLIPEALENLQGRAKEKESLSVQTELPLQNNP
LYYDNVRQDFYVREEATFKINKNQASNDSSEQTFDNFTENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDN
EAKISQSSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQQILLAPYLFTLAKNDFIVLA
EKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSINEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAE
SARALLAELATCKNPYSCAHGRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE

Sequences:

>Translated_695_residues
MIDNFHLVYHFLSVKNEKRALAFCVIIRINLKKQESEIIVGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSS
KIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESG
TKLVAKGGNIETLEPLAKRVGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAG
NGDLRQVIAAIYGIGTAKKMRQIKGSDLDFELTGYVSLPELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRF
PFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEALSEGVLIPEALENLQGRAKEKESLSVQTELPLQNNP
LYYDNVRQDFYVREEATFKINKNQASNDSSEQTFDNFTENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDN
EAKISQSSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQQILLAPYLFTLAKNDFIVLA
EKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSINEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAE
SARALLAELATCKNPYSCAHGRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE
>Mature_695_residues
MIDNFHLVYHFLSVKNEKRALAFCVIIRINLKKQESEIIVGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSS
KIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESG
TKLVAKGGNIETLEPLAKRVGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAG
NGDLRQVIAAIYGIGTAKKMRQIKGSDLDFELTGYVSLPELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRF
PFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEALSEGVLIPEALENLQGRAKEKESLSVQTELPLQNNP
LYYDNVRQDFYVREEATFKINKNQASNDSSEQTFDNFTENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDN
EAKISQSSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQQILLAPYLFTLAKNDFIVLA
EKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSINEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAE
SARALLAELATCKNPYSCAHGRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.9882005899705, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=29.8850574712644, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=29.8850574712644, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=28.2674772036474, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=28.2674772036474, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI91992162, Length=262, Percent_Identity=32.4427480916031, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI91992160, Length=262, Percent_Identity=32.4427480916031, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI310128480, Length=306, Percent_Identity=28.1045751633987, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=29.6875, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=31.25, Blast_Score=109, Evalue=7e-24,
Organism=Escherichia coli, GI1790612, Length=337, Percent_Identity=41.5430267062315, Blast_Score=248, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=35.423197492163, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17562796, Length=358, Percent_Identity=30.1675977653631, Blast_Score=140, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=34.8082595870207, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=27.1954674220963, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=559, Percent_Identity=21.824686940966, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=184, Percent_Identity=32.0652173913043, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=34.0425531914894, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17136970, Length=360, Percent_Identity=28.6111111111111, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 78337; Mature: 78337

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNFHLVYHFLSVKNEKRALAFCVIIRINLKKQESEIIVGKIIELNEALANQIAAGEVV
CCCCHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKI
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESGTKLVAKGGNIETLEPLAKRV
CCCHHHEEEEEECCCCCCCCHHHHHHHHEEECCCCCCCCCCEEEECCCCCCHHHHHHHHH
GTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAG
CCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCC
NGDLRQVIAAIYGIGTAKKMRQIKGSDLDFELTGYVSLPELTRANRNYITILINGRFIKN
CCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEEECHHHHCCCCCEEEEEEECHHHHH
FLLNRAILEGYGNRLMVGRFPFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKA
HHHHHHHHHCCCCEEEEEECCEEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IDEALSEGVLIPEALENLQGRAKEKESLSVQTELPLQNNPLYYDNVRQDFYVREEATFKI
HHHHHHCCCCCHHHHHHHHCCCCCHHCCEEEEECCCCCCCEEECCCCCCEEEECCCEEEE
NKNQASNDSSEQTFDNFTENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDN
ECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEECCCC
EAKISQSSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQ
CCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHH
QILLAPYLFTLAKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSIN
HHHHHHHHHHHCCCCEEEEECCHHHHHHHCHHHHHCCCCCEEEECCCCEEEHHHHHHHHH
EMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLAELATCKNPYSCAH
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
GRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIDNFHLVYHFLSVKNEKRALAFCVIIRINLKKQESEIIVGKIIELNEALANQIAAGEVV
CCCCHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKI
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESGTKLVAKGGNIETLEPLAKRV
CCCHHHEEEEEECCCCCCCCHHHHHHHHEEECCCCCCCCCCEEEECCCCCCHHHHHHHHH
GTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAG
CCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCC
NGDLRQVIAAIYGIGTAKKMRQIKGSDLDFELTGYVSLPELTRANRNYITILINGRFIKN
CCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEEECHHHHCCCCCEEEEEEECHHHHH
FLLNRAILEGYGNRLMVGRFPFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKA
HHHHHHHHHCCCCEEEEEECCEEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IDEALSEGVLIPEALENLQGRAKEKESLSVQTELPLQNNPLYYDNVRQDFYVREEATFKI
HHHHHHCCCCCHHHHHHHHCCCCCHHCCEEEEECCCCCCCEEECCCCCCEEEECCCEEEE
NKNQASNDSSEQTFDNFTENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDN
ECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEECCCC
EAKISQSSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQ
CCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHH
QILLAPYLFTLAKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSIN
HHHHHHHHHHHCCCCEEEEECCHHHHHHHCHHHHHCCCCCEEEECCCCEEEHHHHHHHHH
EMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLAELATCKNPYSCAH
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
GRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]