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The map label for this gene is ptpL

Identifier: 15674184

GI number: 15674184

Start: 2284177

End: 2284614

Strand: Reverse

Name: ptpL

Synonym: L67624

Alternate gene names: 15674184

Gene position: 2284614-2284177 (Counterclockwise)

Preceding gene: 15674185

Following gene: 30024074

Centisome position: 96.58

GC content: 33.56

Gene sequence:

>438_bases
ATGGAAAAGATTGTTTTTGTCTGTTTAGGAAATATTTGTCGTAGCCCAATGGCAGAATTTGTCATGAAAGATTTAGTTGA
AAAGGCAGGAAATGAATCAAATTTTTTGATTGAAAGTCGAGCAACTTCTTCTTGGGAGCATGGAAATCCAATTCATTCTG
GAACCCAAACAAAACTAAAAGAACAAAAGATTGCTTTTGACCTTCAAAAAGGAAGTCAAAAAATCAGTAGTGAAGATTTT
TATGAATTTGATAAAATTATCGCAATGGATGAATCCAATTTAGAAAATCTTAGAAAAATGGCACCAGAAGGAACGAGTCA
AAAAATCGCGATGCTTTTAGAACAAGGTGTTCCAGATCCATGGTTTACGGGCGATTTCCAAGAAACTTATCAACTTGTTA
AGACGGGTTGTCAAAGATTATTGGATGAAATTGTATAA

Upstream 100 bases:

>100_bases
TTCATTTTAGAATTCTGTCAGTAATATCTTGTGAAATAGGGTATAATAGAATAAATGCTCAAAATTAGTTAATTTATAAA
TGATATAAAGTAAGGAAGTA

Downstream 100 bases:

>100_bases
AATATTTCAAATAAAATAAACCGATGTGAGAAAATCTCACATTAAAACTTGACTTTGCTAATAACAAGGTCTATAATGAA
AGGCATGGAGGCGAGATTTG

Product: tyrosine phosphatase

Products: NA

Alternate protein names: LMPTP [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSWEHGNPIHSGTQTKLKEQKIAFDLQKGSQKISSEDF
YEFDKIIAMDESNLENLRKMAPEGTSQKIAMLLEQGVPDPWFTGDFQETYQLVKTGCQRLLDEIV

Sequences:

>Translated_145_residues
MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSWEHGNPIHSGTQTKLKEQKIAFDLQKGSQKISSEDF
YEFDKIIAMDESNLENLRKMAPEGTSQKIAMLLEQGVPDPWFTGDFQETYQLVKTGCQRLLDEIV
>Mature_145_residues
MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSWEHGNPIHSGTQTKLKEQKIAFDLQKGSQKISSEDF
YEFDKIIAMDESNLENLRKMAPEGTSQKIAMLLEQGVPDPWFTGDFQETYQLVKTGCQRLLDEIV

Specific function: Dephosphorylates the phosphotyrosine-containing proteins. Involved in ethanol stress resistance [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=152, Percent_Identity=34.2105263157895, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI6005988, Length=152, Percent_Identity=32.2368421052632, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325330, Length=135, Percent_Identity=39.2592592592593, Blast_Score=91, Evalue=5e-20,
Organism=Drosophila melanogaster, GI78706770, Length=150, Percent_Identity=35.3333333333333, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78706772, Length=150, Percent_Identity=35.3333333333333, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI78706766, Length=153, Percent_Identity=34.640522875817, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI78706768, Length=153, Percent_Identity=34.640522875817, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI78706764, Length=133, Percent_Identity=36.8421052631579, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI78711846, Length=152, Percent_Identity=36.1842105263158, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16469; Mature: 16469

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSWEHGNPIHSGTQTKLK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
EQKIAFDLQKGSQKISSEDFYEFDKIIAMDESNLENLRKMAPEGTSQKIAMLLEQGVPDP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCC
WFTGDFQETYQLVKTGCQRLLDEIV
CCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEKIVFVCLGNICRSPMAEFVMKDLVEKAGNESNFLIESRATSSWEHGNPIHSGTQTKLK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
EQKIAFDLQKGSQKISSEDFYEFDKIIAMDESNLENLRKMAPEGTSQKIAMLLEQGVPDP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCC
WFTGDFQETYQLVKTGCQRLLDEIV
CCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]