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The map label for this gene is gntZ

Identifier: 15674167

GI number: 15674167

Start: 2270252

End: 2271160

Strand: Reverse

Name: gntZ

Synonym: L53699

Alternate gene names: 15674167

Gene position: 2271160-2270252 (Counterclockwise)

Preceding gene: 15674170

Following gene: 15674166

Centisome position: 96.01

GC content: 39.05

Gene sequence:

>909_bases
ATGATGAAATTTGGTATGATTGGTTTAGGGAAAATGGGAATGAATCTTGTGAAAAATGCCGTTGACCATGAGATTGAAGT
TGTTGCTTACGATCTAAATACAAAAGCGGTAGAGGAAGCTAAGGATTACTCAGACAAAATTACCGCTGTCAGCACAATTG
AAAATTTACTGACAGAATTGCCAGCAAGCAAAATTGTTTGGTTGATGCTTCCGGCAGGAACTCCTACAAATTCAACGATT
GAAATGCTTTCTGAAAAGTTGTCAGCTGGAGATATTCTGATAGACGGTGGAAATTCTAATTACAAAGATAATTTAGAACA
AAATAAATTACTGACAGAAAAAGGAATTAAATTTTTTGATGTTGGAACCTCTGGTGGAATGGCTGGAGCTCGTCAAGGCG
GGAATTTTATGATTGGTGGAGATGATGAAAAATCTTGGACAATCATAGAACCAATCTTCAAAGCAATCTCAATGGAAGAG
GGCTACCTCTATACAGGGAAACTTGGCAGTGGTCATTACTTGAAAATGATTCATAATGGAATTGAATATGGGATGATGCA
AGCGATCGCTGAAGGATTTGAAATTTTGGAAGAGTCACCATTTGATTATGACTATGAAGCCGTTGCAAAATTATGGAATC
ACGGCTCAGTAATCCGAAGCTGGTTGATGGAGCTTGCTCAAGAACAATTTTCAAAAGACCCTAAACTAGACCAAATTATC
GGTCATGTTCAATCTTCAGGAGAAGGAAAATGGACCGTTGAAGAAAGCTTGGACTTAGGTGTTCCTGCCCCAGTTATTGC
CTTGTCACTAATGATGCGTCAACGCTCATTACAAGAAGATACCATGACCGGAAAAGTAGTTGCCGCTTTGCGCAATGGCT
TTGGCGGACATGACGTAGAACAAAAATAA

Upstream 100 bases:

>100_bases
TTGACAAATCAGAAAATATTTTACAAAAAATATTGTTGACAAATGAAAAAAATTACTTATACTAAAGTTATAAAATGAAA
GCGATGCCACGGAGGAAAAA

Downstream 100 bases:

>100_bases
TTTACTGACAGATGAGAAGCGTAAGCTAACTAGGACAAAAAACTTCTGTCAGTAAAAAACTACTGATGATGAAAGAATTT
TAAAGTCTGTCAGTAAATAT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MMKFGMIGLGKMGMNLVKNAVDHEIEVVAYDLNTKAVEEAKDYSDKITAVSTIENLLTELPASKIVWLMLPAGTPTNSTI
EMLSEKLSAGDILIDGGNSNYKDNLEQNKLLTEKGIKFFDVGTSGGMAGARQGGNFMIGGDDEKSWTIIEPIFKAISMEE
GYLYTGKLGSGHYLKMIHNGIEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQEQFSKDPKLDQII
GHVQSSGEGKWTVEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHDVEQK

Sequences:

>Translated_302_residues
MMKFGMIGLGKMGMNLVKNAVDHEIEVVAYDLNTKAVEEAKDYSDKITAVSTIENLLTELPASKIVWLMLPAGTPTNSTI
EMLSEKLSAGDILIDGGNSNYKDNLEQNKLLTEKGIKFFDVGTSGGMAGARQGGNFMIGGDDEKSWTIIEPIFKAISMEE
GYLYTGKLGSGHYLKMIHNGIEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQEQFSKDPKLDQII
GHVQSSGEGKWTVEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHDVEQK
>Mature_302_residues
MMKFGMIGLGKMGMNLVKNAVDHEIEVVAYDLNTKAVEEAKDYSDKITAVSTIENLLTELPASKIVWLMLPAGTPTNSTI
EMLSEKLSAGDILIDGGNSNYKDNLEQNKLLTEKGIKFFDVGTSGGMAGARQGGNFMIGGDDEKSWTIIEPIFKAISMEE
GYLYTGKLGSGHYLKMIHNGIEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQEQFSKDPKLDQII
GHVQSSGEGKWTVEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHDVEQK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=293, Percent_Identity=33.1058020477816, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1788341, Length=293, Percent_Identity=33.1058020477816, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17542558, Length=293, Percent_Identity=35.4948805460751, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321695, Length=293, Percent_Identity=37.8839590443686, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321977, Length=289, Percent_Identity=38.0622837370242, Blast_Score=165, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24639279, Length=291, Percent_Identity=36.0824742268041, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 33185; Mature: 33185

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFGMIGLGKMGMNLVKNAVDHEIEVVAYDLNTKAVEEAKDYSDKITAVSTIENLLTEL
CCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHC
PASKIVWLMLPAGTPTNSTIEMLSEKLSAGDILIDGGNSNYKDNLEQNKLLTEKGIKFFD
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHCCEEEE
VGTSGGMAGARQGGNFMIGGDDEKSWTIIEPIFKAISMEEGYLYTGKLGSGHYLKMIHNG
CCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
IEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQEQFSKDPKLDQII
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHH
GHVQSSGEGKWTVEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHDVE
HHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QK
CC
>Mature Secondary Structure
MMKFGMIGLGKMGMNLVKNAVDHEIEVVAYDLNTKAVEEAKDYSDKITAVSTIENLLTEL
CCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHC
PASKIVWLMLPAGTPTNSTIEMLSEKLSAGDILIDGGNSNYKDNLEQNKLLTEKGIKFFD
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHCCEEEE
VGTSGGMAGARQGGNFMIGGDDEKSWTIIEPIFKAISMEEGYLYTGKLGSGHYLKMIHNG
CCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
IEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQEQFSKDPKLDQII
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHH
GHVQSSGEGKWTVEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHDVE
HHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]