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The map label for this gene is ezrA

Identifier: 15674133

GI number: 15674133

Start: 2224277

End: 2226007

Strand: Reverse

Name: ezrA

Synonym: L7722

Alternate gene names: 15674133

Gene position: 2226007-2224277 (Counterclockwise)

Preceding gene: 15674134

Following gene: 15674132

Centisome position: 94.1

GC content: 34.49

Gene sequence:

>1731_bases
ATGTCAAGTACTGTCATTATCCTCATTGTTGTCTTATTAGTTATTCTCGTAGCCTTTTATGCTTTTGCAATATTAATGCG
AAAGAAAACAGAAGACCGTATACTAGCCTTAGAAGAGCGAAAGGAATCGCTTTTCGATTTGCCTGTTCAAGAAGAAATTG
ATTCTGTTAAAAAAATGCATCTCGTCGGACAATCGCAAACAATTTTCCGTGAATGGAACCAAAAATGGCTTGACTTATCA
TCAAATTCTTTTGCTGATTTGGAAGAACATATTTTTGAAGCTGAACAATTAAACGATTCATTCCATTTTTTCCGTGCTCG
TGAATCTGTAGCGGATAGTGAGGCACAAATTGAATTAATGGAAGGTGATGTCGAAGGAATTCGTCAAGGTGTTGCTCAAC
TTGTTGAACAAGAAAAGCGTAATTCAAATAAAATTCAAGAGTCCCTTGATTTATATGATAACTTACGTAGCGATATTGCT
GACAATGCAGATTTGTATGGAACAGTTATTACTGAACTTGAAAAACATTTAGCCAATATCGAAACAGAATTTTCTCAGTT
TGTAACGCTAAACTCAACAGGTGATCCGATTGAAGCGGCTGAAGTTTTGGAGACTGCTGAAGAACATACGATTGCTTTAC
GTGCAATTACAGAACAAATTCCATCATTTATTAAAACAATTGAAAAAGATGTTCCTAAACGACTTGAAGAATTGCAAGAA
GCGAGTGATAAATTCGTTGCAGAAGAATACATTCTTCCCGATAATGTCAACATTAAAGAAAGAATGGATGATTTACATGA
TCATCTCGTTGAAAGTAGTTCATTATTAGAACAATTTGAACTAGATCGAGTAGAAGCTGAACTTGGTTTAATTCAAGAAA
AAGTTGAAGAACTTTATGCTATTTTTGAAAGAGAATATAGCGCACGTCGAAATGTTGAAAAACGTTCATCAGTTCTCAAA
GAATATATTGAACATATCAGAGCAAATAATAAAAATCTTCTCCTTGAAATTGACCATGTTACACAAGCCTATATCCTTTC
TGGAAACGAAAAAGGATATGTTAGAGGTTATCAAGAACATTTAGAATCTCTTGACTCAGATGTGGATGAAATTCTAGGAA
ATATTCAAGCTAAAACAATGCCTTACTCAATTCTTTCACGTAGAGTAAATTCAGTAGTCAATGCGCTTGAAGATATTGAG
AAGAACCAAATTAAGATTAGTGATACCCTTACAGGACTCAGAGATGAAGAAAGAGCAGCTCAAGAAATTGCAGAACGCTT
TGATTCTGAACTTCGTACAATAAAACGTTATGTTGAAAAATGTAATCTCCCTGGACTTCCTAAAGATTATCTCGACTTGT
TCTTCACAACAGGAGATCGAGTACAAAATCTGTTCAAAGAATTAGGACGAGTTAGAATCAACATTGATACAATTAATCAT
CTTGTTGACGTAAGCACTGAAGATATGCACGTTTTAAAAGAAGCAACGACTAATTTGACTGACCATGCGGTATTAGCTGA
ACAATTGATTCAATATGCTAATCGTTATAAAGCTGCAAATGAACAAGTAGCACAAGGGATCTCAAGAGCGCTTCAATTAT
TTGAAAACAGCCGTGACTATGATGGTTCATTTGATGAAATTTCAAAAACGCTAGAACTTGTAGAACCGGGTGCAGCTTCT
AGAATTTCAGGAGTTTATTTTAAAAATAAACCTACTCCTGATTACTTATAA

Upstream 100 bases:

>100_bases
TGTATTTCTTTGACGCATTATGCTATAATTATATTTGAGATTTTCTATCTATTTAAAATCTATCTAACCTAAGTAATTAA
ATCATTTTATGGAGTAAAGC

Downstream 100 bases:

>100_bases
AATAAATAAAAGCAAGGTAAATAGCCTTGCTTTTATTTATTGGGTTATAAATTCTGAATATTCGCATAATATCGTTAGGT
AAAACATGTAAAATTATTAT

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLS
SNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIELMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIA
DNADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
ASDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQFELDRVEAELGLIQEKVEELYAIFEREYSARRNVEKRSSVLK
EYIEHIRANNKNLLLEIDHVTQAYILSGNEKGYVRGYQEHLESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDIE
KNQIKISDTLTGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFTTGDRVQNLFKELGRVRINIDTINH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKAANEQVAQGISRALQLFENSRDYDGSFDEISKTLELVEPGAAS
RISGVYFKNKPTPDYL

Sequences:

>Translated_576_residues
MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLS
SNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIELMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIA
DNADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
ASDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQFELDRVEAELGLIQEKVEELYAIFEREYSARRNVEKRSSVLK
EYIEHIRANNKNLLLEIDHVTQAYILSGNEKGYVRGYQEHLESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDIE
KNQIKISDTLTGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFTTGDRVQNLFKELGRVRINIDTINH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKAANEQVAQGISRALQLFENSRDYDGSFDEISKTLELVEPGAAS
RISGVYFKNKPTPDYL
>Mature_575_residues
SSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLSS
NSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIELMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIAD
NADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQEA
SDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQFELDRVEAELGLIQEKVEELYAIFEREYSARRNVEKRSSVLKE
YIEHIRANNKNLLLEIDHVTQAYILSGNEKGYVRGYQEHLESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDIEK
NQIKISDTLTGLRDEERAAQEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFTTGDRVQNLFKELGRVRINIDTINHL
VDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKAANEQVAQGISRALQLFENSRDYDGSFDEISKTLELVEPGAASR
ISGVYFKNKPTPDYL

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_LACLA (Q9CDR6)

Other databases:

- EMBL:   AE005176
- PIR:   G86893
- RefSeq:   NP_268308.1
- GeneID:   1115828
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L7722
- NMPDR:   fig|272623.1.peg.2206
- HOGENOM:   HBG697174
- OMA:   MDIQELH
- ProtClustDB:   PRK04778
- BioCyc:   LLAC272623:L7722-MONOMER
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 66130; Mature: 65999

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfaef58c)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVGQSQTIFREWNQKWLDLSSNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIELM
HCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
EGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIADNADLYGTVITELEKHLANI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
HHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQFELDRVEAELGLIQEKVEELYA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFEREYSARRNVEKRSSVLKEYIEHIRANNKNLLLEIDHVTQAYILSGNEKGYVRGYQEH
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHEEHHCCCCCCCHHHHHHHH
LESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDIEKNQIKISDTLTGLRDEERAA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHCCCHHHHHH
QEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFTTGDRVQNLFKELGRVRINIDTINH
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKAANEQVAQGISRALQLFENSRDY
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGSFDEISKTLELVEPGAASRISGVYFKNKPTPDYL
CCCHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCCH
>Mature Secondary Structure 
SSTVIILIVVLLVILVAFYAFAILMRKKTEDRILALEERKESLFDLPVQEEIDSVKKMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVGQSQTIFREWNQKWLDLSSNSFADLEEHIFEAEQLNDSFHFFRARESVADSEAQIELM
HCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
EGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIADNADLYGTVITELEKHLANI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQIPSFIKTIEKDVPKRLEELQE
HHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQFELDRVEAELGLIQEKVEELYA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFEREYSARRNVEKRSSVLKEYIEHIRANNKNLLLEIDHVTQAYILSGNEKGYVRGYQEH
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHEEHHCCCCCCCHHHHHHHH
LESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDIEKNQIKISDTLTGLRDEERAA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHCCCHHHHHH
QEIAERFDSELRTIKRYVEKCNLPGLPKDYLDLFFTTGDRVQNLFKELGRVRINIDTINH
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHH
LVDVSTEDMHVLKEATTNLTDHAVLAEQLIQYANRYKAANEQVAQGISRALQLFENSRDY
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGSFDEISKTLELVEPGAASRISGVYFKNKPTPDYL
CCCHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11337471