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The map label for this gene is noxD

Identifier: 15674108

GI number: 15674108

Start: 2194782

End: 2196113

Strand: Reverse

Name: noxD

Synonym: L178227

Alternate gene names: 15674108

Gene position: 2196113-2194782 (Counterclockwise)

Preceding gene: 15674109

Following gene: 15674107

Centisome position: 92.84

GC content: 37.31

Gene sequence:

>1332_bases
ATGAAAATTGTTATTGTTGGAAGCTCCCACGCCGGAATTTGTGCCGGATTACGGGCGCTTGAAGAATACCCAGAAGCCGA
AATTACGCTTTATGATAAGCGTAATCAGGTTTCTTTTGTTTCTCAAGGAATTATTTCTTATCTGGCGGGTCAAAAATCTG
TCCTTAATCAATCTAGTTATTCTTCGGTAGAAGAACTAAAAGCTGCTGGTTTAAACATGCAAATGGAAACGGTGGTTGAA
GAGATTGATACCAAAAATAAACGGCTATTTTATCGGAGAGTCAATTCCAAAAAGACGAAACTCGCTCTCTATGATAAATT
GATTTTTGCTACGGGTTCTTATCCGGCAATGACCTCTGTTCCTTTTGATAAAAAAAGCAAACTTTACTTTTTAAAAAGTA
TGGATGATGCAATAAAAACAGATGAATTTCTGAAAACAGCCAAAAATATTGCAGTAATTGGTGGTGGAATGACCGGAGTT
GAAGTTGCTCGGATTGCCCAAGAAAGAGGAATTCAGACAACACTCATTCATCGCAATAAAAATCTTTTAAACGATTATCT
TGATGAACCAGCAAGTCATTTATTGGAAAGTTGGATGAATGCAGAGGGAACGCGTCTTCTATTAAATACAGAAGTGACAG
AAATTGGGTTTGACGAAGAAAATACAATTATTCAAACAGCAAATGGTCAGAAAATTCCTGTTGATGGAGTAATCTTTACG
ATTGGTTTTCGGCCTAATTCTTATCTTCTGAATCAACAAGTTGAGTTAGGAGATAGCGGAGCGGTTATTGTTGATGAATA
CATGCAAACCTCTTGTCCAGATGTTTTTGCTGTCGGAGATGTTTCAACGACTTATGTTAATTTGTTGGAAAAAAGCTATT
ATCTGCCACATGCTTCGGATGCTGTTCGCGATGGTGAAATTGCGGCGATTAATTTACTTGCTCCTCGCCAAAAAATTAAT
AGTAGTCAGGGAACTTATCATGTTCCAATGAATAATTTAGTGATGGCTATGACTGGGATTACAATAAGACAGGCAGTTGA
TGCTGGTTATGATGCAGATGCGGTTCATTTACTAAATGAACACTTAGACGGATATTCACCAAGTAATATTTGGATGATTT
ATGAGAGACGCACTCATCAAATTCTTGGTTTACAATGTATTGGAAAAACGAGCGATATGGCAGAGTACGTCAATATTTTC
TCACTTGCGATTCAACAGAAATTAAAAATTGAGGATATTGAGTTCACAGACTTTTATTTTGAACATGGCTACAAAGACCC
TCGGGGTCTCAATCGCATATTAGCTCGACTAGTAAGGGAGAATGAAAGGTAG

Upstream 100 bases:

>100_bases
TGAAGTTAAAATTCGTGCGACAGGTGAAGTTGTTGAAATTAACAAAGATGAACTTGTCAATACTATTGAAATTTTAAGTA
AATAATAAAAGAGATTTACT

Downstream 100 bases:

>100_bases
ATTGTGTGGAAACGACTAATAAAGAGATAGTTTATTGTCAAAAAGTGCTTCACTTGCTTGAGGATTTGCAGAAAGTTCAA
CAAAGCATTGAATCCTTTGC

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKIVIVGSSHAGICAGLRALEEYPEAEITLYDKRNQVSFVSQGIISYLAGQKSVLNQSSYSSVEELKAAGLNMQMETVVE
EIDTKNKRLFYRRVNSKKTKLALYDKLIFATGSYPAMTSVPFDKKSKLYFLKSMDDAIKTDEFLKTAKNIAVIGGGMTGV
EVARIAQERGIQTTLIHRNKNLLNDYLDEPASHLLESWMNAEGTRLLLNTEVTEIGFDEENTIIQTANGQKIPVDGVIFT
IGFRPNSYLLNQQVELGDSGAVIVDEYMQTSCPDVFAVGDVSTTYVNLLEKSYYLPHASDAVRDGEIAAINLLAPRQKIN
SSQGTYHVPMNNLVMAMTGITIRQAVDAGYDADAVHLLNEHLDGYSPSNIWMIYERRTHQILGLQCIGKTSDMAEYVNIF
SLAIQQKLKIEDIEFTDFYFEHGYKDPRGLNRILARLVRENER

Sequences:

>Translated_443_residues
MKIVIVGSSHAGICAGLRALEEYPEAEITLYDKRNQVSFVSQGIISYLAGQKSVLNQSSYSSVEELKAAGLNMQMETVVE
EIDTKNKRLFYRRVNSKKTKLALYDKLIFATGSYPAMTSVPFDKKSKLYFLKSMDDAIKTDEFLKTAKNIAVIGGGMTGV
EVARIAQERGIQTTLIHRNKNLLNDYLDEPASHLLESWMNAEGTRLLLNTEVTEIGFDEENTIIQTANGQKIPVDGVIFT
IGFRPNSYLLNQQVELGDSGAVIVDEYMQTSCPDVFAVGDVSTTYVNLLEKSYYLPHASDAVRDGEIAAINLLAPRQKIN
SSQGTYHVPMNNLVMAMTGITIRQAVDAGYDADAVHLLNEHLDGYSPSNIWMIYERRTHQILGLQCIGKTSDMAEYVNIF
SLAIQQKLKIEDIEFTDFYFEHGYKDPRGLNRILARLVRENER
>Mature_443_residues
MKIVIVGSSHAGICAGLRALEEYPEAEITLYDKRNQVSFVSQGIISYLAGQKSVLNQSSYSSVEELKAAGLNMQMETVVE
EIDTKNKRLFYRRVNSKKTKLALYDKLIFATGSYPAMTSVPFDKKSKLYFLKSMDDAIKTDEFLKTAKNIAVIGGGMTGV
EVARIAQERGIQTTLIHRNKNLLNDYLDEPASHLLESWMNAEGTRLLLNTEVTEIGFDEENTIIQTANGQKIPVDGVIFT
IGFRPNSYLLNQQVELGDSGAVIVDEYMQTSCPDVFAVGDVSTTYVNLLEKSYYLPHASDAVRDGEIAAINLLAPRQKIN
SSQGTYHVPMNNLVMAMTGITIRQAVDAGYDADAVHLLNEHLDGYSPSNIWMIYERRTHQILGLQCIGKTSDMAEYVNIF
SLAIQQKLKIEDIEFTDFYFEHGYKDPRGLNRILARLVRENER

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=353, Percent_Identity=24.3626062322946, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI65787454, Length=353, Percent_Identity=24.3626062322946, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI226437568, Length=353, Percent_Identity=24.3626062322946, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789065, Length=316, Percent_Identity=25.3164556962025, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788892, Length=184, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789765, Length=194, Percent_Identity=27.8350515463918, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082354, Length=324, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49629; Mature: 49629

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVIVGSSHAGICAGLRALEEYPEAEITLYDKRNQVSFVSQGIISYLAGQKSVLNQSSY
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCCCHH
SSVEELKAAGLNMQMETVVEEIDTKNKRLFYRRVNSKKTKLALYDKLIFATGSYPAMTSV
HHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHEEEHEEEEECCCCCCCCCC
PFDKKSKLYFLKSMDDAIKTDEFLKTAKNIAVIGGGMTGVEVARIAQERGIQTTLIHRNK
CCCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCH
NLLNDYLDEPASHLLESWMNAEGTRLLLNTEVTEIGFDEENTIIQTANGQKIPVDGVIFT
HHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCEECCCCCCCCEEEECCCCCCCCCEEEEE
IGFRPNSYLLNQQVELGDSGAVIVDEYMQTSCPDVFAVGDVSTTYVNLLEKSYYLPHASD
EEECCCCEEECCEEEECCCCCEEEEHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCC
AVRDGEIAAINLLAPRQKINSSQGTYHVPMNNLVMAMTGITIRQAVDAGYDADAVHLLNE
CCCCCCEEEEEEECCHHHCCCCCCEEECCHHHEEEHHHCHHHHHHHCCCCCCHHHHHHHH
HLDGYSPSNIWMIYERRTHQILGLQCIGKTSDMAEYVNIFSLAIQQKLKIEDIEFTDFYF
HCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHH
EHGYKDPRGLNRILARLVRENER
HCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIVIVGSSHAGICAGLRALEEYPEAEITLYDKRNQVSFVSQGIISYLAGQKSVLNQSSY
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCCCHH
SSVEELKAAGLNMQMETVVEEIDTKNKRLFYRRVNSKKTKLALYDKLIFATGSYPAMTSV
HHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHEEEHEEEEECCCCCCCCCC
PFDKKSKLYFLKSMDDAIKTDEFLKTAKNIAVIGGGMTGVEVARIAQERGIQTTLIHRNK
CCCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCH
NLLNDYLDEPASHLLESWMNAEGTRLLLNTEVTEIGFDEENTIIQTANGQKIPVDGVIFT
HHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCEECCCCCCCCEEEECCCCCCCCCEEEEE
IGFRPNSYLLNQQVELGDSGAVIVDEYMQTSCPDVFAVGDVSTTYVNLLEKSYYLPHASD
EEECCCCEEECCEEEECCCCCEEEEHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCC
AVRDGEIAAINLLAPRQKINSSQGTYHVPMNNLVMAMTGITIRQAVDAGYDADAVHLLNE
CCCCCCEEEEEEECCHHHCCCCCCEEECCHHHEEEHHHCHHHHHHHCCCCCCHHHHHHHH
HLDGYSPSNIWMIYERRTHQILGLQCIGKTSDMAEYVNIFSLAIQQKLKIEDIEFTDFYF
HCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHH
EHGYKDPRGLNRILARLVRENER
HCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]