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The map label for this gene is pmsR

Identifier: 15673988

GI number: 15673988

Start: 2084276

End: 2084794

Strand: Reverse

Name: pmsR

Synonym: L67708

Alternate gene names: 15673988

Gene position: 2084794-2084276 (Counterclockwise)

Preceding gene: 15673989

Following gene: 15673987

Centisome position: 88.13

GC content: 35.07

Gene sequence:

>519_bases
ATGGCAACAGAAAGAGCAATATTTGCAGGTGGATGTTTTTGGTGTATGGTTCAACCTTTTGAAGAACGAGAAGGGATTTT
ATCTGTGATAAGTGGCTATACAGGTGGAAATGTTGAAAATCCAACTTATGAACAAGTAAAAAAACACTTGACTGGTCATA
CAGAAGCAGTAGAAATTATTTTTGATAATAGTAAAATTACCTATCAAAGTCTTGTTGAACTTTATTGGACACTCACGGAC
CCAACAGATGCTTTTGGTCAATTTGAAGACCGTGGGGATAACTATCGTCCAGTCATTTTTGTTGAAAACGAAGAACAAGA
AAAAATTGCCAAAGAAAGCAAAGCGCAATTGCAAGCCAGCGGAAATTTTGATTCACCTATTGTGACAAGTATTGAAACCG
TTCAAAAATTCTGGCCAGCAGAAGACTACCATCAAGGATTTTACAAAAAAAATCCAGAAGATTATGCCCAATCAAGTAAA
ATTCGTCATGATTTTTTGGAAAAACAATGGAAAAAATAA

Upstream 100 bases:

>100_bases
CTTATAAAAATTTCTGTCAGTAAAAAAGTAGCTTAATTGGCTACTTTTTTTTGAGCTATGCTATAATATTTCACAAGACA
AACAAAGTGAAGGAGAAATA

Downstream 100 bases:

>100_bases
TTAATTTTCCGACTTAATGATAATAGAAAGAGAAAATGACTTTTTATAATTACCTTATGCGCCATCGTGCACCAGTAGAA
AAAGATGATGCAACTCGTCT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MATERAIFAGGCFWCMVQPFEEREGILSVISGYTGGNVENPTYEQVKKHLTGHTEAVEIIFDNSKITYQSLVELYWTLTD
PTDAFGQFEDRGDNYRPVIFVENEEQEKIAKESKAQLQASGNFDSPIVTSIETVQKFWPAEDYHQGFYKKNPEDYAQSSK
IRHDFLEKQWKK

Sequences:

>Translated_172_residues
MATERAIFAGGCFWCMVQPFEEREGILSVISGYTGGNVENPTYEQVKKHLTGHTEAVEIIFDNSKITYQSLVELYWTLTD
PTDAFGQFEDRGDNYRPVIFVENEEQEKIAKESKAQLQASGNFDSPIVTSIETVQKFWPAEDYHQGFYKKNPEDYAQSSK
IRHDFLEKQWKK
>Mature_171_residues
ATERAIFAGGCFWCMVQPFEEREGILSVISGYTGGNVENPTYEQVKKHLTGHTEAVEIIFDNSKITYQSLVELYWTLTDP
TDAFGQFEDRGDNYRPVIFVENEEQEKIAKESKAQLQASGNFDSPIVTSIETVQKFWPAEDYHQGFYKKNPEDYAQSSKI
RHDFLEKQWKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=35.6687898089172, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=35.6687898089172, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=35.1851851851852, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=40.7894736842105, Blast_Score=116, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.1724137931034, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=28.0254777070064, Blast_Score=68, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=29.6969696969697, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=29.0909090909091, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA2_LACLA (Q9CE42)

Other databases:

- EMBL:   AE005176
- PIR:   F86875
- RefSeq:   NP_268163.1
- ProteinModelPortal:   Q9CE42
- SMR:   Q9CE42
- GeneID:   1115682
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L67708
- NMPDR:   fig|272623.1.peg.2060
- HOGENOM:   HBG748152
- OMA:   SIFPYEK
- ProtClustDB:   PRK14054
- BioCyc:   LLAC272623:L67708-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19878; Mature: 19747

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATERAIFAGGCFWCMVQPFEEREGILSVISGYTGGNVENPTYEQVKKHLTGHTEAVEII
CCCCCEEEECCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEE
FDNSKITYQSLVELYWTLTDPTDAFGQFEDRGDNYRPVIFVENEEQEKIAKESKAQLQAS
ECCCCCCHHHHHHHHHHCCCCHHHHHCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCC
GNFDSPIVTSIETVQKFWPAEDYHQGFYKKNPEDYAQSSKIRHDFLEKQWKK
CCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATERAIFAGGCFWCMVQPFEEREGILSVISGYTGGNVENPTYEQVKKHLTGHTEAVEII
CCCCEEEECCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEE
FDNSKITYQSLVELYWTLTDPTDAFGQFEDRGDNYRPVIFVENEEQEKIAKESKAQLQAS
ECCCCCCHHHHHHHHHHCCCCHHHHHCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCC
GNFDSPIVTSIETVQKFWPAEDYHQGFYKKNPEDYAQSSKIRHDFLEKQWKK
CCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471