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The map label for this gene is pepO

Identifier: 15673785

GI number: 15673785

Start: 1866399

End: 1868282

Strand: Direct

Name: pepO

Synonym: L49741

Alternate gene names: 15673785

Gene position: 1866399-1868282 (Clockwise)

Preceding gene: 15673784

Following gene: 15673788

Centisome position: 78.9

GC content: 35.24

Gene sequence:

>1884_bases
ATGACAAGGATTCAAGATGATTTATTCGCTACTGTTAATGCTGAATGGTTAGAAAATGCAGAAATTCCTGCAGACAAACC
AAGAATTTCAGCTTTTGATGAATTAGTACTAAAAAATGAGAAAAATTTGGCTAAAGATTTAGCTGATTTATCACAAAACC
TACCTACTGATAATCCAGAGTTGCTTGAAGCAATCAAATTTTATAATAAAGCAGGAGATTGGCAAACCAGAGAAAAAGCG
GACTTTTCTGCCGTAAAAAATGAACTTGCTAAAGTTGAAACTTTAAATACTTTTGAAGATTTTAAAAATAATTTGACTCA
ACTCGTTTTCCATTCACAGGCACCTCTTCCGTTTTCTTTTAGTGTTGAACCTGATATGAAAGATGCTATTCACTATTCTC
TTGGATTCTCTGGCCCGGGTTTGATTTTACCTGATACCACTTATTATAATGATGAACACCCTAGAAAAAAAGAATTACTT
GATTTTTGGGCTAAAAATACAAGCGAAATTTTAAAGACATTTGATGTTGAAAATGCAGAAGAGATTGCAAAGTCTGCCCT
TAAATTCGATGCTCTTTTAGTTCCATCAGCAAATACTTCTGAAGAGTGGGCAAAATATGCTGAACTTTATCATCCAATTT
CTACTGACAGCTTTGTCAGTAAAGTTAAAAACCTGGATTTAAAATCTTTAATTAAAGATTTAGTAAAAACTGAACCTGAT
AAAGTCATTGTTTACGAAGATCGTTTTTATGAATCATTTGATTCACTTATCAATGAAGAAAATTGGTCACTCATTAAAGC
TTGGATGCTGACAAAAATTGCACGTGGCGCTACTTCTTTCTTCAATGAAGACCTTAGAATTCTTGGTGGAGCTTATGGAC
GTTTCCTTTCAAATGTTCAAGAAGCAAGAAGTCAAGAAAAACATCAACTTGATTTGACTGAGTCTTATTTTAGCCAAGTG
ATTGGTTTATTCTATGGTAAAAAATATTTTGGTGAAGCTGCTAAGGCCGATGTCAAACGGATGGTCACTGCAATGATTAA
AGTTTACCAAGCGCGTTTGTCTAAAAATGAGTGGCTCAGTCAAGAAACAGCTGAAAAAGCCATTGAAAAATTGGATGCTA
TTACTCCTTTCATTGGTTTCCCAGATAAATTGCCTGAAATTTATAGTCGTTTAAAAACAACTTCTGGCTCTCTCTATGAA
GATGCCCTTAAATTCGATGAAATTTTGACTGCTCGAACTTTTGAAAAATTCTCAGAAGATGTTGATAAAACAAGCTGGCA
TATGCCTGCTCATATGGTCAATGCTTATTATAGTCCTGATAGTAATACAATTGTTTTTCCAGCAGCAATTTTGCAAGCTC
CTTTTTACTCTCTTGAACAATCTTCATCACAAAATTACGGTGGAATCGGCACAGTTATTGCTCACGAAATTTCTCACGCT
TTTGATAACAACGGTGCCCAATTCGATAAAGAAGGAAATTTGAACAAATGGTGGTTAGATGAAGATTATGAAGCTTTTGA
AGAAAAGCAAAAAGAAATGATTGCACTCTTTGACGGCGTAGAAACCGAAGCTGGTCCAGCAAACGGAAAACTCATTGTGT
CAGAAAATATTGCTGACCAAGGAGGAATTACAGCGGCACTGACAGCAGCTAAAGATGAGAAAGACGTTGATTTGAAGGCT
TTCTTTAGTCAGTGGGCTAAGATTTGGCGCATGAAAGCAAGTAAAGAATTCCAACAAATGCTTTTGTCAATGGATGTTCA
TGCACCCGCTAAACTTCGTGCCAATATTCCTCCAACAAATCTCGAAGAGTTTTACGAAACTTTTGATGTTAAAGAAACTG
ATAAGATGTATCGTGCACCAGAAAATCGTCTTAAAATTTGGTAA

Upstream 100 bases:

>100_bases
ATTAATTTTCAAATTGCTGTTAAAAAGTGCTGATGGAATTCGTCAGCGCTTTTTTGTAAGTATGATATAATATAAAAAAT
ATCCATAATAGGAGGTCGAT

Downstream 100 bases:

>100_bases
TAGTTAATTGAATACAAAAAGTACTTCTAAAATATAGAAGTACTTTTTATTTATTAGAGCAGTTCATCTTCAATAATTAT
TTTCCCTTGAGCTGTAAAAG

Product: neutral endopeptidase

Products: NA

Alternate protein names: Endopeptidase O

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTRIQDDLFATVNAEWLENAEIPADKPRISAFDELVLKNEKNLAKDLADLSQNLPTDNPELLEAIKFYNKAGDWQTREKA
DFSAVKNELAKVETLNTFEDFKNNLTQLVFHSQAPLPFSFSVEPDMKDAIHYSLGFSGPGLILPDTTYYNDEHPRKKELL
DFWAKNTSEILKTFDVENAEEIAKSALKFDALLVPSANTSEEWAKYAELYHPISTDSFVSKVKNLDLKSLIKDLVKTEPD
KVIVYEDRFYESFDSLINEENWSLIKAWMLTKIARGATSFFNEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQV
IGLFYGKKYFGEAAKADVKRMVTAMIKVYQARLSKNEWLSQETAEKAIEKLDAITPFIGFPDKLPEIYSRLKTTSGSLYE
DALKFDEILTARTFEKFSEDVDKTSWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLEQSSSQNYGGIGTVIAHEISHA
FDNNGAQFDKEGNLNKWWLDEDYEAFEEKQKEMIALFDGVETEAGPANGKLIVSENIADQGGITAALTAAKDEKDVDLKA
FFSQWAKIWRMKASKEFQQMLLSMDVHAPAKLRANIPPTNLEEFYETFDVKETDKMYRAPENRLKIW

Sequences:

>Translated_627_residues
MTRIQDDLFATVNAEWLENAEIPADKPRISAFDELVLKNEKNLAKDLADLSQNLPTDNPELLEAIKFYNKAGDWQTREKA
DFSAVKNELAKVETLNTFEDFKNNLTQLVFHSQAPLPFSFSVEPDMKDAIHYSLGFSGPGLILPDTTYYNDEHPRKKELL
DFWAKNTSEILKTFDVENAEEIAKSALKFDALLVPSANTSEEWAKYAELYHPISTDSFVSKVKNLDLKSLIKDLVKTEPD
KVIVYEDRFYESFDSLINEENWSLIKAWMLTKIARGATSFFNEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQV
IGLFYGKKYFGEAAKADVKRMVTAMIKVYQARLSKNEWLSQETAEKAIEKLDAITPFIGFPDKLPEIYSRLKTTSGSLYE
DALKFDEILTARTFEKFSEDVDKTSWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLEQSSSQNYGGIGTVIAHEISHA
FDNNGAQFDKEGNLNKWWLDEDYEAFEEKQKEMIALFDGVETEAGPANGKLIVSENIADQGGITAALTAAKDEKDVDLKA
FFSQWAKIWRMKASKEFQQMLLSMDVHAPAKLRANIPPTNLEEFYETFDVKETDKMYRAPENRLKIW
>Mature_626_residues
TRIQDDLFATVNAEWLENAEIPADKPRISAFDELVLKNEKNLAKDLADLSQNLPTDNPELLEAIKFYNKAGDWQTREKAD
FSAVKNELAKVETLNTFEDFKNNLTQLVFHSQAPLPFSFSVEPDMKDAIHYSLGFSGPGLILPDTTYYNDEHPRKKELLD
FWAKNTSEILKTFDVENAEEIAKSALKFDALLVPSANTSEEWAKYAELYHPISTDSFVSKVKNLDLKSLIKDLVKTEPDK
VIVYEDRFYESFDSLINEENWSLIKAWMLTKIARGATSFFNEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQVI
GLFYGKKYFGEAAKADVKRMVTAMIKVYQARLSKNEWLSQETAEKAIEKLDAITPFIGFPDKLPEIYSRLKTTSGSLYED
ALKFDEILTARTFEKFSEDVDKTSWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLEQSSSQNYGGIGTVIAHEISHAF
DNNGAQFDKEGNLNKWWLDEDYEAFEEKQKEMIALFDGVETEAGPANGKLIVSENIADQGGITAALTAAKDEKDVDLKAF
FSQWAKIWRMKASKEFQQMLLSMDVHAPAKLRANIPPTNLEEFYETFDVKETDKMYRAPENRLKIW

Specific function: Endopeptidase with broad substrate specificity for several oligopeptides

COG id: COG3590

COG function: function code O; Predicted metalloendopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M13 family

Homologues:

Organism=Homo sapiens, GI164519138, Length=659, Percent_Identity=25.3414264036419, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI164519140, Length=659, Percent_Identity=25.3414264036419, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI164519136, Length=659, Percent_Identity=25.3414264036419, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI4503443, Length=659, Percent_Identity=25.3414264036419, Blast_Score=220, Evalue=4e-57,
Organism=Homo sapiens, GI239049391, Length=677, Percent_Identity=27.178729689808, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI153945761, Length=660, Percent_Identity=23.9393939393939, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI82617560, Length=660, Percent_Identity=23.7878787878788, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI153945836, Length=660, Percent_Identity=23.9393939393939, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI153945771, Length=660, Percent_Identity=23.9393939393939, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI157426891, Length=665, Percent_Identity=23.0075187969925, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI116256333, Length=330, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI116256331, Length=330, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI116256329, Length=330, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI116256327, Length=330, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI90403592, Length=690, Percent_Identity=23.9130434782609, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4557691, Length=357, Percent_Identity=24.3697478991597, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI86562497, Length=683, Percent_Identity=25.7686676427526, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25148650, Length=683, Percent_Identity=26.0614934114202, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17533333, Length=404, Percent_Identity=26.4851485148515, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32563993, Length=310, Percent_Identity=29.3548387096774, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17564342, Length=433, Percent_Identity=26.5588914549654, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71987442, Length=548, Percent_Identity=23.9051094890511, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17534401, Length=322, Percent_Identity=27.639751552795, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17570047, Length=600, Percent_Identity=22.3333333333333, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71998977, Length=293, Percent_Identity=27.3037542662116, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71998975, Length=293, Percent_Identity=27.3037542662116, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71988640, Length=236, Percent_Identity=27.1186440677966, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994787, Length=324, Percent_Identity=21.9135802469136, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17533319, Length=352, Percent_Identity=22.7272727272727, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532485, Length=279, Percent_Identity=24.7311827956989, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24643425, Length=664, Percent_Identity=24.2469879518072, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI45551938, Length=536, Percent_Identity=25.5597014925373, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI45550777, Length=536, Percent_Identity=25.5597014925373, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17737761, Length=471, Percent_Identity=28.4501061571125, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640050, Length=659, Percent_Identity=23.3687405159332, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24640052, Length=659, Percent_Identity=23.3687405159332, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24650487, Length=369, Percent_Identity=24.390243902439, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221474862, Length=365, Percent_Identity=24.9315068493151, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24650765, Length=271, Percent_Identity=26.1992619926199, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281362760, Length=354, Percent_Identity=25.1412429378531, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650885, Length=348, Percent_Identity=26.4367816091954, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24650889, Length=349, Percent_Identity=24.3553008595989, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21355943, Length=359, Percent_Identity=22.2841225626741, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641622, Length=202, Percent_Identity=29.7029702970297, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPO_LACLA (Q07744)

Other databases:

- EMBL:   L18760
- EMBL:   AE005176
- PIR:   C86850
- PIR:   F53290
- RefSeq:   NP_267960.1
- ProteinModelPortal:   Q07744
- SMR:   Q07744
- GeneID:   1115468
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L49741
- NMPDR:   fig|272623.1.peg.1849
- HOGENOM:   HBG701001
- OMA:   NGICGED
- ProtClustDB:   CLSK871767
- BioCyc:   LLAC272623:L49741-MONOMER
- GO:   GO:0006508
- InterPro:   IPR000718
- InterPro:   IPR018497
- InterPro:   IPR008753
- PANTHER:   PTHR11733
- PRINTS:   PR00786

Pfam domain/function: PF01431 Peptidase_M13; PF05649 Peptidase_M13_N

EC number: NA

Molecular weight: Translated: 71538; Mature: 71407

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 476-476 ACT_SITE 539-539

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIQDDLFATVNAEWLENAEIPADKPRISAFDELVLKNEKNLAKDLADLSQNLPTDNPE
CCCCCCHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHH
LLEAIKFYNKAGDWQTREKADFSAVKNELAKVETLNTFEDFKNNLTQLVFHSQAPLPFSF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
SVEPDMKDAIHYSLGFSGPGLILPDTTYYNDEHPRKKELLDFWAKNTSEILKTFDVENAE
CCCCCHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHH
EIAKSALKFDALLVPSANTSEEWAKYAELYHPISTDSFVSKVKNLDLKSLIKDLVKTEPD
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCC
KVIVYEDRFYESFDSLINEENWSLIKAWMLTKIARGATSFFNEDLRILGGAYGRFLSNVQ
EEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARSQEKHQLDLTESYFSQVIGLFYGKKYFGEAAKADVKRMVTAMIKVYQARLSKNEWLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QETAEKAIEKLDAITPFIGFPDKLPEIYSRLKTTSGSLYEDALKFDEILTARTFEKFSED
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDKTSWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLEQSSSQNYGGIGTVIAHEISHA
HHHHCCCCCHHHHHHEECCCCCEEEEHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHH
FDNNGAQFDKEGNLNKWWLDEDYEAFEEKQKEMIALFDGVETEAGPANGKLIVSENIADQ
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCC
GGITAALTAAKDEKDVDLKAFFSQWAKIWRMKASKEFQQMLLSMDVHAPAKLRANIPPTN
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCC
LEEFYETFDVKETDKMYRAPENRLKIW
HHHHHHHCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TRIQDDLFATVNAEWLENAEIPADKPRISAFDELVLKNEKNLAKDLADLSQNLPTDNPE
CCCCCHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHH
LLEAIKFYNKAGDWQTREKADFSAVKNELAKVETLNTFEDFKNNLTQLVFHSQAPLPFSF
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
SVEPDMKDAIHYSLGFSGPGLILPDTTYYNDEHPRKKELLDFWAKNTSEILKTFDVENAE
CCCCCHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHH
EIAKSALKFDALLVPSANTSEEWAKYAELYHPISTDSFVSKVKNLDLKSLIKDLVKTEPD
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCC
KVIVYEDRFYESFDSLINEENWSLIKAWMLTKIARGATSFFNEDLRILGGAYGRFLSNVQ
EEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARSQEKHQLDLTESYFSQVIGLFYGKKYFGEAAKADVKRMVTAMIKVYQARLSKNEWLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QETAEKAIEKLDAITPFIGFPDKLPEIYSRLKTTSGSLYEDALKFDEILTARTFEKFSED
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDKTSWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLEQSSSQNYGGIGTVIAHEISHA
HHHHCCCCCHHHHHHEECCCCCEEEEHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHH
FDNNGAQFDKEGNLNKWWLDEDYEAFEEKQKEMIALFDGVETEAGPANGKLIVSENIADQ
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCC
GGITAALTAAKDEKDVDLKAFFSQWAKIWRMKASKEFQQMLLSMDVHAPAKLRANIPPTN
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCC
LEEFYETFDVKETDKMYRAPENRLKIW
HHHHHHHCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8244921; 11337471