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The map label for this gene is pmsX

Identifier: 15673535

GI number: 15673535

Start: 1593915

End: 1594466

Strand: Direct

Name: pmsX

Synonym: L193644

Alternate gene names: 15673535

Gene position: 1593915-1594466 (Clockwise)

Preceding gene: 15673508

Following gene: 15673554

Centisome position: 67.38

GC content: 35.14

Gene sequence:

>552_bases
ATGAGTACAGAACGAGCTATTTTTGCTGGTGGTTGTTTTTGGTGTATGGTTGAACCTTTTGAAGAACGTCCAGGTATTTT
GGCTGTAACTAGTGGTTATACTGGTGGACATATCGAATACCCTACTTATGACCAAGTCCTCTCAAAAGCTTCTGGCCATA
CGGAAGCAGTTGAAATTTTATTTGATAATGAATTGATTTCTTATGATGAACTATTAGATATTTATTGGTCATTGATTGAC
CCCACTGATGCTGACGGACAAATTTATGACCGAGGTGCAAATTATCGTCCAGTAATTTTTGTTGAAAGTGAAGAACAAAG
AATTGCTGCTCAAAAAAGTAAAATTGCCTTAGAGAAATCTGGAATTTGGGATAAACCAATTGTTGTTCCGATTGAAGAGG
CAAAAACTTTTTGGCCAGCTGAAGAATATCATCAACAATACTATAAAAAAGATCCTAAACGTTACCAAGCGATGCACAAA
GCACGTGAACGTTATTTAGCCTTACAACGTTTTAAAGGGAAATTTAAATTTTTAAGAAAAAACACTAGATAA

Upstream 100 bases:

>100_bases
ACAAAAAAGAAAAATTCAAAATTTTTAAAGTTCGAGTCAAATGATGAGGTGGCATTTTTTTCACATGATATAATTAAATT
AGAGCAAATGGAGGTATAAA

Downstream 100 bases:

>100_bases
CTAGTGTTTTTATTTTATATTTGGCCACTCTTTACCAAACCATTCTTGGTATAGGTCTTCCACAATTTTGACTGTCGTCA
TTGTCATTTCTGGGGAAAGT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSTERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEILFDNELISYDELLDIYWSLID
PTDADGQIYDRGANYRPVIFVESEEQRIAAQKSKIALEKSGIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHK
ARERYLALQRFKGKFKFLRKNTR

Sequences:

>Translated_183_residues
MSTERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEILFDNELISYDELLDIYWSLID
PTDADGQIYDRGANYRPVIFVESEEQRIAAQKSKIALEKSGIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHK
ARERYLALQRFKGKFKFLRKNTR
>Mature_182_residues
STERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEILFDNELISYDELLDIYWSLIDP
TDADGQIYDRGANYRPVIFVESEEQRIAAQKSKIALEKSGIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHKA
RERYLALQRFKGKFKFLRKNTR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=37.7358490566038, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=37.7358490566038, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=39.0909090909091, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=40.1315789473684, Blast_Score=113, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=30, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=35.2112676056338, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=34.5070422535211, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=35.036496350365, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA1_LACLA (Q9CFC8)

Other databases:

- EMBL:   AE005176
- PIR:   A86819
- RefSeq:   NP_267709.1
- ProteinModelPortal:   Q9CFC8
- SMR:   Q9CFC8
- GeneID:   1115212
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L193644
- NMPDR:   fig|272623.1.peg.1595
- HOGENOM:   HBG748152
- OMA:   HKARERY
- ProtClustDB:   CLSK697798
- BioCyc:   LLAC272623:L193644-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 21331; Mature: 21200

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEIL
CCCCCEEEECCEEEEEECCHHCCCCEEEEECCCCCCEECCCCHHHHHHHCCCCCEEEEEE
FDNELISYDELLDIYWSLIDPTDADGQIYDRGANYRPVIFVESEEQRIAAQKSKIALEKS
ECCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHEECCC
GIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHKARERYLALQRFKGKFKFLRK
CCCCCCEEEEHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NTR
CCC
>Mature Secondary Structure 
STERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEIL
CCCCEEEECCEEEEEECCHHCCCCEEEEECCCCCCEECCCCHHHHHHHCCCCCEEEEEE
FDNELISYDELLDIYWSLIDPTDADGQIYDRGANYRPVIFVESEEQRIAAQKSKIALEKS
ECCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHEECCC
GIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHKARERYLALQRFKGKFKFLRK
CCCCCCEEEEHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NTR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471