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The map label for this gene is hisK

Identifier: 15673198

GI number: 15673198

Start: 1237620

End: 1238429

Strand: Direct

Name: hisK

Synonym: L37351

Alternate gene names: 15673198

Gene position: 1237620-1238429 (Clockwise)

Preceding gene: 15673197

Following gene: 15673200

Centisome position: 52.32

GC content: 29.51

Gene sequence:

>810_bases
ATGAAAAAATTAGATTATCATTTCCACTCTCATTTTTCGGCTGATAGCGAGGAGCTTCCTAGAAAGCATGTGACAGAAGC
TATAGCACATGGTTTAGAAGAAATTTGTTTTACAGAGCATCGAGATTTTTATTTTCCAGGAATGGATTTTTCACTAAATC
TACCTGAGTATTTTCAAGAAATCAATCGATTACAAGCAGAATTTAAAGATAAAATTAAAATAAAAATTGGCTTGGAAATG
GGAATTGATTTACGTTTTAAATCAGAAATTAATCAGTTTATTGATTCGGCTCCTTTTGACTTTGTGATTGCCTCTGTTCA
TGAAATTGGAGATATTGAAGTTTATGACGGAACAGAATTTTATCTACAGAAAATAAAAGAAGAAGCACAAAGAGAATATC
TTTTAGCTTGTTTAGATGTTGTTCAAAATTTTGAGAATTATAATTCATTTGGTCATTTAGATTATGTTGCTAGATATGGG
CCTTACACGGATAAATCAATAAAGTTTGCAGAGAATCGGGAGATTTTATTTGAAATCTTGCGGGCTTTAGCTTCAAAAGA
AAAAGCATTAGAAATAAATACTAGATTGTTTGATGATCCGAAAACTGAACAATTTTATAGTGATTTATTGATTAATTTTA
AAAAATTAGGTGGAAAATTTATAACTTTAGGAACGGACAGTCATATAGCAAAGCGTGATTGGCTTTCAATTCATAAAGCA
AGAACTTTAATTAAAAAAGCTGGTTTTCACGAACTAGCAACTTTTAGTGGGATGAAAATTGATAAAAATAAAAAGTCTAT
TAAAGAATAA

Upstream 100 bases:

>100_bases
TCAGCAAGGTATTTCTCTAGAAGAAGTACGGCAAAAAGCAAAAGAACGGCATCAGCTAGAAGGAAATAAGAAGGAATTTC
ATACAAGGACGGCAGATTAA

Downstream 100 bases:

>100_bases
TAGACTTTTTATATTATGATGCTAAATCTTTCTCAAGTAGCGCAAGACGTTCTTGAACTTCTTGATTTGATAGTTGGTGG
GCTTTGATGTAACGGTTATT

Product: histidinol phosphatase

Products: NA

Alternate protein names: HolPase

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMDFSLNLPEYFQEINRLQAEFKDKIKIKIGLEM
GIDLRFKSEINQFIDSAPFDFVIASVHEIGDIEVYDGTEFYLQKIKEEAQREYLLACLDVVQNFENYNSFGHLDYVARYG
PYTDKSIKFAENREILFEILRALASKEKALEINTRLFDDPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKA
RTLIKKAGFHELATFSGMKIDKNKKSIKE

Sequences:

>Translated_269_residues
MKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMDFSLNLPEYFQEINRLQAEFKDKIKIKIGLEM
GIDLRFKSEINQFIDSAPFDFVIASVHEIGDIEVYDGTEFYLQKIKEEAQREYLLACLDVVQNFENYNSFGHLDYVARYG
PYTDKSIKFAENREILFEILRALASKEKALEINTRLFDDPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKA
RTLIKKAGFHELATFSGMKIDKNKKSIKE
>Mature_269_residues
MKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMDFSLNLPEYFQEINRLQAEFKDKIKIKIGLEM
GIDLRFKSEINQFIDSAPFDFVIASVHEIGDIEVYDGTEFYLQKIKEEAQREYLLACLDVVQNFENYNSFGHLDYVARYG
PYTDKSIKFAENREILFEILRALASKEKALEINTRLFDDPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKA
RTLIKKAGFHELATFSGMKIDKNKKSIKE

Specific function: Unknown

COG id: COG1387

COG function: function code ER; Histidinol phosphatase and related hydrolases of the PHP family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PHP hydrolase family. HisK subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS9_LACLA (Q02150)

Other databases:

- EMBL:   U92974
- EMBL:   AE005176
- PIR:   D47754
- PIR:   H86776
- RefSeq:   NP_267372.1
- ProteinModelPortal:   Q02150
- SMR:   Q02150
- GeneID:   1114864
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L37351
- NMPDR:   fig|272623.1.peg.1251
- HOGENOM:   HBG476803
- OMA:   ELGGKYI
- ProtClustDB:   CLSK697637
- BioCyc:   LLAC272623:L37351-MONOMER
- BRENDA:   3.1.3.15
- InterPro:   IPR010140
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- PANTHER:   PTHR21039
- SMART:   SM00481
- TIGRFAMs:   TIGR01856

Pfam domain/function: PF02811 PHP; SSF89550 PHP-like

EC number: =3.1.3.15

Molecular weight: Translated: 31473; Mature: 31473

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMDFSLNLPEYFQE
CCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEECCHHHHHH
INRLQAEFKDKIKIKIGLEMGIDLRFKSEINQFIDSAPFDFVIASVHEIGDIEVYDGTEF
HHHHHHHHHCCEEEEEEEEECCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHH
YLQKIKEEAQREYLLACLDVVQNFENYNSFGHLDYVARYGPYTDKSIKFAENREILFEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEECCCHHHHHHHH
RALASKEKALEINTRLFDDPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKA
HHHHCCCHHEEEHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
RTLIKKAGFHELATFSGMKIDKNKKSIKE
HHHHHHCCHHHHHHHCCCEECCCHHHCCC
>Mature Secondary Structure
MKKLDYHFHSHFSADSEELPRKHVTEAIAHGLEEICFTEHRDFYFPGMDFSLNLPEYFQE
CCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEECCHHHHHH
INRLQAEFKDKIKIKIGLEMGIDLRFKSEINQFIDSAPFDFVIASVHEIGDIEVYDGTEF
HHHHHHHHHCCEEEEEEEEECCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHH
YLQKIKEEAQREYLLACLDVVQNFENYNSFGHLDYVARYGPYTDKSIKFAENREILFEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEECCCHHHHHHHH
RALASKEKALEINTRLFDDPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKA
HHHHCCCHHEEEHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
RTLIKKAGFHELATFSGMKIDKNKKSIKE
HHHHHHCCHHHHHHHCCCEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471