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The map label for this gene is gyrA

Identifier: 15673093

GI number: 15673093

Start: 1121779

End: 1124268

Strand: Direct

Name: gyrA

Synonym: L0282

Alternate gene names: 15673093

Gene position: 1121779-1124268 (Clockwise)

Preceding gene: 15673092

Following gene: 15673094

Centisome position: 47.42

GC content: 40.0

Gene sequence:

>2490_bases
ATGCAAGACAAAAATGTTATCAATGTCAATTTAGTTGAGGAGATGAAGACGTCATTTCGTGACTATGCAATGTCAGTTAT
CGTTGCACGGGCACTTCCTGATGTACGTGATGGTTTAAAACCCGTTCACCGTCGTATTCTCTACGGAATGAATGAACTTG
GAAATACTCCAGATAAACCACATAAAAAATCGGCACGTATTGTCGGTGAAGTTATGGGTAAATATCACCCACACGGAGAC
AGTTCAATCTATGAAGCAATGGTACGTATGGCTCAATGGTGGTCTTATCGTCATATGCTTGCTGACGGACACGGTAACTT
TGGTTCAATGGACGGTGACGGTGCCGCAGCGATGCGTTATACCGAAGCTCGTTTAAGTAAAATTGCCATGGAAATGTTGC
GTGATATCAACAAAAATACCGTTGATTTCATGGACAATTTCGACGGTACTGAACGTGAACCGCTCGTTTTACCTGCTCGT
TTTCCAAACCTTTTAGTTAATGGAACCACAGGGATTGCCGTTGGGATGGCAACAAACATTCCACCACATAATCTGGGTGA
AACAATCGATGCAGTAGATATGCTCATGGAAAATCCAGAAGCATCAGTTACTGATTTAATGTCTGTGATTCCTGGACCTG
ACTTCCCAACAGGGGCTTTGGTTATGGGTAAATCTGGTATTCGCCGTGCTTATGAAACTGGTAAAGGTTCAATTACATTA
CGTGCAAAAACCCACATTGAAGAAATGGCTGGTGGGAAAGAACGTATTGTTGTGACTGAACTACCATATATGGTCAATAA
AGCACGGTTGGTTGAACATATTGTTCGTTTAAACCATGAAAAACGAATTGAAGGATTGACTGCGGTTCGTGATGAATCCA
ACCGTGAAGGAATTCGCGTGGTTATCGAAGTTCGTCGTGACTTATCAGCACACGTTATCTTAAATAATCTGTTCAAACTA
ACAAGTTTGCAAACTTCATTTGGTTTCAATATGTTGGCTATCGAAAAAGGAATTCCTAAAATTCTTTCTTTGAAAGAAAT
CTTAGTTGATTATATTGAACATCAAATAGAAGTTGTTGAACGTCGTACAGCCTTTGATAAAGCACGTGCAGAAGCACGCG
CACATATCTTGGAAGGTTTACGTATCGCTCTTGACAATATTGACCGTATCATTACAATTATCCGTGAATCACAAACGGAT
GCCATTGCACAAAAAACAATGATGGATGAATTCCTCCTCTCTGAAAAACAATCGCAAGCTATTCTTGATATGCGTTTGCG
TCGTTTGACCGGATTGGAACGTGATAAAATTGAGGCAGAATATCAAGATTTAGTCGCTTTGATTGCTGACTTAGCCGATA
TTTTGGCAAAACCTGAACGTGTTAAGAAAATTATTCGTGAAGAATTAGAAGAAGTTAAACGTAAATTTGCTGACAAACGT
CGAACAGAATTGTTAGTTGGTGAAGTTCTTACTCTTGAAGATGAAGATTTGATTGAGGAAGAAGATGTATTGATTACTTT
ATCAAATAAAGGATATATCAAACGTCTAGCTAATGACGAATTCCGTGCCCAAAATCGTGGTGGACGTGGTGTTCAAGGAA
TGGGAATGTCTGATGATGACTTTGTTCAACATTTGGTATCTACATCAACACATGATCATTTACTCTTCTTTACAAATCTT
GGACGTGTTTACCGAATGAAAGGATATGAAATTCCTGAATACGGTCGGACAGCAAAAGGATTGCCAATTGTCAATCTCCT
CAAGCTTGATGACGGTGAAAAAATTGCAACAATCATCAATGTTGACCGTGACCAAGCGGCGAAATATCTCTTCTTCACAA
CACGTAACGGAATTGTTAAACGAACTTCAACCAGTCAATTTAGCAATATTCGGACAAATGGTTTGAAGGCTTTGAAACTC
CGAGATGGTGACGAACTGATTAATGTGCTTAGAACTTCGGGTGAAGATGAGGTGATTATCGGAACTCATTTGGGATACTC
AGTTCGCTTTAAAGGTGCAGTTGTTCGTGATATGGGACGTGCAGCAGCCGGTGTTAAAGGGGTTAACCTCAGAGAAGGCG
ACTATGTTGTCGGAACTTCACGAATTGATGACAGTCAAGAAGTCCTTGTTATCTCAGAAAATGGTCTTGGTAAACGAACT
CAGGCTTCAGAATATCCAACAAAAGGCCGTGGTGGTAAAGGGATGAAAGTCATGAATGTCACAGAAAGAACTGGTAAATT
AGCTGGTTTAACTGCTGTCAATGGTGACGAAGATTTGATGGTTATTACAGATACAGGGGTTATTATCCGTACAAATGTGG
CTAACATTTCTCAAACTGGTCGAGCTGCCCAAGGGGTTAAAGTAATGCGACTTGATGATGAAGCACAAATTGTAACCTTT
GCACTTGTAGATCCAGTCATTGAAGATGAAGAAGTTGATGCGCCAGAACTTACTGATGAAACAATTTCTACTGACAATAA
CGAAGAATAA

Upstream 100 bases:

>100_bases
TGGTATAATATAGTTAATCTGTTTGTCAATTGGGGCAAACTCTTCCGAAAGCAAGAAAGGAAAGTAAAATTTCATTTTAA
TGAGATTTTACAAGGCAAAC

Downstream 100 bases:

>100_bases
TTGAAAAGAAAGTCTGCCAGTTACTGACAGACTTTCTGACTGAATAAGATGGTGCTGACAGGTCTGTCAGTAAAAATTAG
AGAATGAAAAAAATAATAAT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 829; Mature: 829

Protein sequence:

>829_residues
MQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKPHKKSARIVGEVMGKYHPHGD
SSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPAR
FPNLLVNGTTGIAVGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYETGKGSITL
RAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRVVIEVRRDLSAHVILNNLFKL
TSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTD
AIAQKTMMDEFLLSEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLADILAKPERVKKIIREELEEVKRKFADKR
RTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDDFVQHLVSTSTHDHLLFFTNL
GRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKL
RDGDELINVLRTSGEDEVIIGTHLGYSVRFKGAVVRDMGRAAAGVKGVNLREGDYVVGTSRIDDSQEVLVISENGLGKRT
QASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTGRAAQGVKVMRLDDEAQIVTF
ALVDPVIEDEEVDAPELTDETISTDNNEE

Sequences:

>Translated_829_residues
MQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKPHKKSARIVGEVMGKYHPHGD
SSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPAR
FPNLLVNGTTGIAVGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYETGKGSITL
RAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRVVIEVRRDLSAHVILNNLFKL
TSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTD
AIAQKTMMDEFLLSEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLADILAKPERVKKIIREELEEVKRKFADKR
RTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDDFVQHLVSTSTHDHLLFFTNL
GRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKL
RDGDELINVLRTSGEDEVIIGTHLGYSVRFKGAVVRDMGRAAAGVKGVNLREGDYVVGTSRIDDSQEVLVISENGLGKRT
QASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTGRAAQGVKVMRLDDEAQIVTF
ALVDPVIEDEEVDAPELTDETISTDNNEE
>Mature_829_residues
MQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKPHKKSARIVGEVMGKYHPHGD
SSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRYTEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPAR
FPNLLVNGTTGIAVGMATNIPPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYETGKGSITL
RAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRVVIEVRRDLSAHVILNNLFKL
TSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVERRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTD
AIAQKTMMDEFLLSEKQSQAILDMRLRRLTGLERDKIEAEYQDLVALIADLADILAKPERVKKIIREELEEVKRKFADKR
RTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDDFVQHLVSTSTHDHLLFFTNL
GRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIINVDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKL
RDGDELINVLRTSGEDEVIIGTHLGYSVRFKGAVVRDMGRAAAGVKGVNLREGDYVVGTSRIDDSQEVLVISENGLGKRT
QASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTGRAAQGVKVMRLDDEAQIVTF
ALVDPVIEDEEVDAPELTDETISTDNNEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=341, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788562, Length=845, Percent_Identity=48.8757396449704, Blast_Score=808, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=624, Percent_Identity=37.6602564102564, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=384, Percent_Identity=23.6979166666667, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=341, Percent_Identity=25.5131964809384, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136538, Length=398, Percent_Identity=23.8693467336683, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92554; Mature: 92554

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKP
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HKKSARIVGEVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRY
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
TEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPARFPNLLVNGTTGIAVGMATNI
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCEEEEEECCC
PPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYETGKGSITL
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHCCCCCEEE
RAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRV
EEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEE
VIEVRRDLSAHVILNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVE
EEEEHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTDAIAQKTMMDEFLLSEKQSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHH
ILDMRLRRLTGLERDKIEAEYQDLVALIADLADILAKPERVKKIIREELEEVKRKFADKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDD
HHHHHHHHEEEECCHHCCCCCCEEEEECCCCHHHHHCCCHHHHHCCCCCCCCCCCCCHHH
FVQHLVSTSTHDHLLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIIN
HHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
VDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKLRDGDELINVLRTSGEDEVII
CCHHHCCEEEEEEECCCEEEECCCHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCCCEEE
GTHLGYSVRFKGAVVRDMGRAAAGVKGVNLREGDYVVGTSRIDDSQEVLVISENGLGKRT
EECCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCC
QASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTG
CCCCCCCCCCCCCCEEEEEEHHHCCCEEEEEEECCCCCEEEEECCCEEEEECCCCHHHCC
RAAQGVKVMRLDDEAQIVTFALVDPVIEDEEVDAPELTDETISTDNNEE
CHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQDKNVINVNLVEEMKTSFRDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGNTPDKP
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HKKSARIVGEVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLADGHGNFGSMDGDGAAAMRY
CHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
TEARLSKIAMEMLRDINKNTVDFMDNFDGTEREPLVLPARFPNLLVNGTTGIAVGMATNI
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEECCCCCEEEECCCCEEEEEECCC
PPHNLGETIDAVDMLMENPEASVTDLMSVIPGPDFPTGALVMGKSGIRRAYETGKGSITL
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHCCCCCEEE
RAKTHIEEMAGGKERIVVTELPYMVNKARLVEHIVRLNHEKRIEGLTAVRDESNREGIRV
EEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEE
VIEVRRDLSAHVILNNLFKLTSLQTSFGFNMLAIEKGIPKILSLKEILVDYIEHQIEVVE
EEEEHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RRTAFDKARAEARAHILEGLRIALDNIDRIITIIRESQTDAIAQKTMMDEFLLSEKQSQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHH
ILDMRLRRLTGLERDKIEAEYQDLVALIADLADILAKPERVKKIIREELEEVKRKFADKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RTELLVGEVLTLEDEDLIEEEDVLITLSNKGYIKRLANDEFRAQNRGGRGVQGMGMSDDD
HHHHHHHHEEEECCHHCCCCCCEEEEECCCCHHHHHCCCHHHHHCCCCCCCCCCCCCHHH
FVQHLVSTSTHDHLLFFTNLGRVYRMKGYEIPEYGRTAKGLPIVNLLKLDDGEKIATIIN
HHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
VDRDQAAKYLFFTTRNGIVKRTSTSQFSNIRTNGLKALKLRDGDELINVLRTSGEDEVII
CCHHHCCEEEEEEECCCEEEECCCHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCCCEEE
GTHLGYSVRFKGAVVRDMGRAAAGVKGVNLREGDYVVGTSRIDDSQEVLVISENGLGKRT
EECCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCC
QASEYPTKGRGGKGMKVMNVTERTGKLAGLTAVNGDEDLMVITDTGVIIRTNVANISQTG
CCCCCCCCCCCCCCEEEEEEHHHCCCEEEEEEECCCCCEEEEECCCEEEEECCCCHHHCC
RAAQGVKVMRLDDEAQIVTFALVDPVIEDEEVDAPELTDETISTDNNEE
CHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]