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The map label for this gene is accC

Identifier: 15672760

GI number: 15672760

Start: 787314

End: 788681

Strand: Direct

Name: accC

Synonym: L0189

Alternate gene names: 15672760

Gene position: 787314-788681 (Clockwise)

Preceding gene: 15672759

Following gene: 15672761

Centisome position: 33.28

GC content: 38.96

Gene sequence:

>1368_bases
ATGTTTAATAAAATTTTGATTGCCAATCGTGGCGAAATTGCTGTAAGAATTATTCGTGCAGCTCGTGAATTAGGAGTGGG
TACAGTTGCCATTTATTCAACTGCAGACCGCGATGCTTTACATGTTCATTTAGCTGACGAAGCAATTTGTGTGGGCCCAG
CTAGAAGTACTGAGTCTTATCTTAATATGAATAATATTCTGTCAGCTGCTGTGGCAACTGGCGCACAAGCGATTCACCCA
GGTTTTGGATTCCTTTCTGAGAATTCAAAATTTGCTCGTCTTTGTGAAGAAATGAATATTAAATTTATCGGTCCGTCAGC
AAAAGTTATGGATATGATGGGTGATAAAATCAATGCTCGTGCAGAAATGATTAAAGCTGGTGTTCCTGTAACACCGGGTT
CTGAGGGCGAAGTTCATACCACTGATGAAGCAGTAAAAATTGCTGAAGAAATTGGCTATCCAATCATGCTTAAAGCATCA
GCTGGTGGTGGTGGTAAAGGAATTCGTAAGGTTAATAATGTTGAGGAACTTGTTCCAGCATTTGAGGCAGCACAAGCGGA
AGCACAAGCAGCTTTTGGTAATGGAGCCATGTTCATCGAACGAATGATTTTCCCAGCGCGTCATATTGAGGTTCAAATCT
TAGGAGATAGTCAAGGAAATGTGATTCATCTTGGTGAACGTGATTGTTCATTGCAAAGAAATAATCAAAAAGTTCTTGAA
GAATCTCCGTCAGTTGCAATTGGACACACTTTACGAAATGAAATAACAGCTGCGGCTGTTAAAGCTGCTCAGCATGTTTC
TTATGAAAATGCGGGAACCATTGAGTTCTTACTTGATGAATCTTCTGGTAAGTTTTATTTCATGGAAATGAACACACGTG
TTCAAGTTGAACATCCGGTCACAGAGTTTGTATCAGGTGTTGATATTGTAAAAGAACAGATTCGTGTAGCCAATGGCAAT
GAATTGTCTGTCAAGCAAGAAGATGTGACTTTTAGTGGACATGCGATTGAATGTCGAATTAATGCGGAAAATCCTAAATT
TAATTTTGCACCAAGTCCAGGAAAAATTACTAATCTTTTCTTGCCAAGTGGTGGAGTTGGTTTGCGGGTTGATAGCGCTA
TGTACAGTGGTTACAGTATTCCGCCATATTATGATAGTATGATTGCTAAAGTCATTGTTCATGGTGAAAATCGTTTTGAA
GCACTGATGAAAATGCAACGCGCCCTTCTTGAATTTGACGTTGAAGGGGTCATTACAAATGTTGATTTCCAACTAGAATT
AATTTCTGACCCACATGTTGTGGCAGGAGATTATGATACAAGCTTCTTAGGAAATGTTTTCTTACCAGAATATCAAAAAG
AAGATTAA

Upstream 100 bases:

>100_bases
CAAAAAATTGTTTTGTTGGGAATGACTTTCTTTTTTATCATTCCTTTCAAAACACCCATTGAGCAAAAGCTCGGGGTATT
TTCCCATATGGAGAACATCT

Downstream 100 bases:

>100_bases
TCAATAGATTAGTGACAGAATTGTCAGATGGCTTACAATTCATCTGTCAGTAAAATTTATAAAAAAATGAGAAAAGGATG
CAAAGATGGCTCTTTTCCAA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESYLNMNNILSAAVATGAQAIHP
GFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINARAEMIKAGVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKAS
AGGGGKGIRKVNNVEELVPAFEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPVTEFVSGVDIVKEQIRVANGN
ELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLFLPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFE
ALMKMQRALLEFDVEGVITNVDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED

Sequences:

>Translated_455_residues
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESYLNMNNILSAAVATGAQAIHP
GFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINARAEMIKAGVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKAS
AGGGGKGIRKVNNVEELVPAFEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPVTEFVSGVDIVKEQIRVANGN
ELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLFLPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFE
ALMKMQRALLEFDVEGVITNVDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED
>Mature_455_residues
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESYLNMNNILSAAVATGAQAIHP
GFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINARAEMIKAGVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKAS
AGGGGKGIRKVNNVEELVPAFEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPVTEFVSGVDIVKEQIRVANGN
ELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLFLPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFE
ALMKMQRALLEFDVEGVITNVDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=453, Percent_Identity=45.6953642384106, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=48.7695749440716, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=48.7695749440716, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=48.7695749440716, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.8609865470852, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.8609865470852, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.8609865470852, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=32.2393822393822, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=32.2393822393822, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=32.2393822393822, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=32.2393822393822, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=32.2393822393822, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=31.1284046692607, Blast_Score=226, Evalue=5e-59,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=52.9279279279279, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1786216, Length=286, Percent_Identity=23.7762237762238, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=452, Percent_Identity=45.7964601769911, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=47.6510067114094, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=453, Percent_Identity=45.0331125827815, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=484, Percent_Identity=30.5785123966942, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=440, Percent_Identity=33.1818181818182, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=440, Percent_Identity=33.1818181818182, Blast_Score=219, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319685, Length=454, Percent_Identity=43.1718061674009, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=44.3458980044346, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=45.4545454545455, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323863, Length=462, Percent_Identity=30.7359307359307, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=502, Percent_Identity=31.8725099601594, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=44.3946188340807, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.5225225225225, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=42.8921568627451, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24586458, Length=511, Percent_Identity=31.5068493150685, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=31.5068493150685, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=31.5068493150685, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=31.5068493150685, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49500; Mature: 49500

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNMNNILSAAVATGAQAIHPGFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINAR
HHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCCCHHH
AEMIKAGVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKASAGGGGKGIRKVNNVEELVPA
HHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHH
FEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHH
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCH
TEFVSGVDIVKEQIRVANGNELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLF
HHHHHHHHHHHHHHEECCCCEEEEEECCEEECCCEEEEEEECCCCCEECCCCCCCEEEEE
LPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFEALMKMQRALLEFDVEGVITN
ECCCCCCEEECHHHHCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCEEEEE
VDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED
CEEEEEEECCCCEEECCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFNKILIANRGEIAVRIIRAARELGVGTVAIYSTADRDALHVHLADEAICVGPARSTESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNMNNILSAAVATGAQAIHPGFGFLSENSKFARLCEEMNIKFIGPSAKVMDMMGDKINAR
HHHHHHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCCCHHH
AEMIKAGVPVTPGSEGEVHTTDEAVKIAEEIGYPIMLKASAGGGGKGIRKVNNVEELVPA
HHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHH
FEAAQAEAQAAFGNGAMFIERMIFPARHIEVQILGDSQGNVIHLGERDCSLQRNNQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHH
ESPSVAIGHTLRNEITAAAVKAAQHVSYENAGTIEFLLDESSGKFYFMEMNTRVQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCH
TEFVSGVDIVKEQIRVANGNELSVKQEDVTFSGHAIECRINAENPKFNFAPSPGKITNLF
HHHHHHHHHHHHHHEECCCCEEEEEECCEEECCCEEEEEEECCCCCEECCCCCCCEEEEE
LPSGGVGLRVDSAMYSGYSIPPYYDSMIAKVIVHGENRFEALMKMQRALLEFDVEGVITN
ECCCCCCEEECHHHHCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCEEEEE
VDFQLELISDPHVVAGDYDTSFLGNVFLPEYQKED
CEEEEEEECCCCEEECCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]