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The map label for this gene is menB

Identifier: 15672711

GI number: 15672711

Start: 734363

End: 735205

Strand: Reverse

Name: menB

Synonym: L0171

Alternate gene names: 15672711

Gene position: 735205-734363 (Counterclockwise)

Preceding gene: 15672712

Following gene: 30024008

Centisome position: 31.08

GC content: 41.64

Gene sequence:

>843_bases
ATGTCAAAATTTAACTGGGTTGCTCTCAACCGTAACTACGAAGATATTATTTATGAAACTTATGATGGAATTGCTAAAAT
TACCATCAATCGTCCTGAAGTCCGCAATGCCTTCCGTCCCAAAACTGTCGTTGAAATGATTGATGCTTTTAGTGTCGCTC
GTGATGATACCAATGTCGGCGTGATTATTTTGACTGGTGCAAATCATGGAAAAGGTGAAGATAAAGAAGCCTTTTGTTCT
GGTGGTGACCAAAAAGTACGTGGAAATGGTGGATATGTTGGTGAAGACCAAATTCCTCGTTTGAACGTTTTAGATTTGCA
ACATTTGATTCGGATTACACCAAAACCTGTCATTGCTATGGTAAATGGTTTTGCCATTGGTGGAGGTCACGTGTTACATA
TCGTTTGTGATTTGACTATCGCTTCTGAAAACGCAAAATTTGGGCAAACTGGTCCGCGTGTTGGTTCTTTTGATGCTGGT
TATGGTGCTGGTTTACTTGCCGCTATGGTTGGGCAAAAGAAAGCACGTGAAATATGGTTCCTCTGCCGTCAATATACTGC
CCAAGAAGCAATGGACATGGGAATGGTTAATACTGTTGTTCCATTTGACCGTCTTGAAGAAGAAACCGTTCAATGGGCCC
AAGAAATGCTTGCCCTCTCACCAATGGCACTTCGTATGCTCAAAGGTTCAATGAATGCTGCAACTGACGGACTTGCTGGA
CTGCAACAATTTGCAGGAGATGCAACACTTATGTTCTATACTACGGATGAAGCCAAAGAAGGACGCGATGCTTTCAAAGA
AAAACGCAAACCTGATTTTGACCAATTTCCAAAATTCCCATAA

Upstream 100 bases:

>100_bases
TGATGAAAATAGATAAAATGGAACTTGGGCTATGCCCAGAACCGCATTTTTCTAATTTTCACAACTTCTAGCGCTCGTCC
TCACATCTTAAAGGAGAATC

Downstream 100 bases:

>100_bases
AAATTTCCCAAATTGCTGACAAAGCGTCTTTTTGACGCTTTTTGTGATTTAAAAGTTACTGACAGGATTTCTGTCAGTAA
AAAATACACAGAAAGGAGAA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSKFNWVALNRNYEDIIYETYDGIAKITINRPEVRNAFRPKTVVEMIDAFSVARDDTNVGVIILTGANHGKGEDKEAFCS
GGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAMVNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAG
YGAGLLAAMVGQKKAREIWFLCRQYTAQEAMDMGMVNTVVPFDRLEEETVQWAQEMLALSPMALRMLKGSMNAATDGLAG
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP

Sequences:

>Translated_280_residues
MSKFNWVALNRNYEDIIYETYDGIAKITINRPEVRNAFRPKTVVEMIDAFSVARDDTNVGVIILTGANHGKGEDKEAFCS
GGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAMVNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAG
YGAGLLAAMVGQKKAREIWFLCRQYTAQEAMDMGMVNTVVPFDRLEEETVQWAQEMLALSPMALRMLKGSMNAATDGLAG
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP
>Mature_279_residues
SKFNWVALNRNYEDIIYETYDGIAKITINRPEVRNAFRPKTVVEMIDAFSVARDDTNVGVIILTGANHGKGEDKEAFCSG
GDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAMVNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAGY
GAGLLAAMVGQKKAREIWFLCRQYTAQEAMDMGMVNTVVPFDRLEEETVQWAQEMLALSPMALRMLKGSMNAATDGLAGL
QQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=268, Percent_Identity=33.2089552238806, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI31542718, Length=267, Percent_Identity=29.5880149812734, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=27.6018099547511, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=27.6018099547511, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=27.6018099547511, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4757966, Length=224, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538581, Length=224, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25453481, Length=224, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538573, Length=224, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4502327, Length=269, Percent_Identity=27.8810408921933, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788597, Length=277, Percent_Identity=63.5379061371841, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1787659, Length=263, Percent_Identity=31.1787072243346, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI221142681, Length=257, Percent_Identity=30.3501945525292, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082183, Length=270, Percent_Identity=27.4074074074074, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=29.5880149812734, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=32.6771653543307, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=32.5490196078431, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=217, Percent_Identity=27.1889400921659, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=197, Percent_Identity=29.4416243654822, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=224, Percent_Identity=25.4464285714286, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=211, Percent_Identity=24.1706161137441, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129971, Length=277, Percent_Identity=31.7689530685921, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24653477, Length=277, Percent_Identity=31.7689530685921, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24653139, Length=269, Percent_Identity=28.6245353159851, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357171, Length=195, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922422, Length=266, Percent_Identity=24.0601503759398, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650670, Length=193, Percent_Identity=30.5699481865285, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24654903, Length=268, Percent_Identity=23.134328358209, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30881; Mature: 30749

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFNWVALNRNYEDIIYETYDGIAKITINRPEVRNAFRPKTVVEMIDAFSVARDDTNVG
CCCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCEE
VIILTGANHGKGEDKEAFCSGGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAM
EEEEECCCCCCCCCCHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHEEE
VNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAGYGAGLLAAMVGQKKAREIWF
ECCEEECCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
LCRQYTAQEAMDMGMVNTVVPFDRLEEETVQWAQEMLALSPMALRMLKGSMNAATDGLAG
HHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure 
SKFNWVALNRNYEDIIYETYDGIAKITINRPEVRNAFRPKTVVEMIDAFSVARDDTNVG
CCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCEE
VIILTGANHGKGEDKEAFCSGGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAM
EEEEECCCCCCCCCCHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHEEE
VNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAGYGAGLLAAMVGQKKAREIWF
ECCEEECCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
LCRQYTAQEAMDMGMVNTVVPFDRLEEETVQWAQEMLALSPMALRMLKGSMNAATDGLAG
HHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]