BacMap

Definition	Lactococcus lactis subsp. lactis Il1403, complete genome.
Accession	NC_002662
Length	2,365,589

Click here to switch to the map view.

The map label for this gene is ftsH

Identifier: 15672003

GI number: 15672003

Start: 25887

End: 27974

Strand: Direct

Name: ftsH

Synonym: L0204

Alternate gene names: 15672003

Gene position: 25887-27974 (Clockwise)

Preceding gene: 15672002

Following gene: 15672004

Centisome position: 1.09

GC content: 40.23

Gene sequence:

>2088_bases
ATGAATAACAACAAACAACCAAAACAAGGAAATTTTGTAAAAAATATCTTGATGTGGGTAATCTTGGCTATTGTTGTTGT
TGTCGGTTTCAATTTCTTCTTCAGTAGTAATCAATCAAGCGTGGATAAAATTAGCTATTCACAATTGATGACGAAACTTG
ACGGTAACAAGATTGAAAACGTCACAATGCAACCTTCTGATAGCTTAATTACTGTAACAGGTGAATATAAAGAACCTGTA
AAAGTAAAAGGAACAAATAATTTCCCACTTTTAGGTAATTCTAGTAGTGAAGTTAAAAACTTCCAAGCTTATATTATTCC
AACTGACAGTGTTGTCAAGGATATCCAAAATGCAGCTAAAAGTAATGATGTAAAACTTAGTGTTGTTCAAGCTTCATCAA
GTGGTATGTGGGTTCAAATTCTCTCATACATCATTCCAATGCTTCTATTTGTTGGTATCTTCTGGCTCATGATGGGCGGA
ATGGGCGCTCGTGGCGGAGGCGGCGGTGGAAATCCGATGTCCTTCGGTAAATCTCGTGCTAAACAACAAGATGGTAAAAC
ATCTAAAGTTCGTTTTGCTGACGTTGCCGGTTCTGAAGAGGAAAAACAAGAGCTTGTAGAAGTTGTTGATTTCCTTAAAA
ATCCGAAAAAATATCATGATTTAGGAGCTCGTATCCCAGCAGGTGTTCTTCTTGAAGGCCCTCCAGGTACAGGTAAAACA
TTGCTTGCTAAGGCTGTTGCCGGTGAAGCAGGAGTTCCTTTCTATAGTATCTCAGGTTCTGATTTCGTTGAAATGTTTGT
CGGTGTCGGTGCCTCACGTGTCCGTGACTTATTTGAAAATGCTAAGAAGACTGCACCATCAATTATCTTTATTGATGAAA
TTGATGCTGTTGGTCGTCAACGTGGCGCAGGTCTTGGTGGTGGTAACGATGAACGTGAACAAACCCTTAACCAATTGCTC
GTTGAAATGGATGGTTTCCAAGATGATGGCAACTCAGTAATCGTTATTGCTGCAACTAACCGTTCAGATGTGCTTGACCC
AGCGCTTTTACGTCCAGGTCGTTTTGACCGTAAAGTCTTGGTCGGAGCTCCAGATGTTAAAGGTCGTGAAGCCGTTCTTA
AAGTTCATGCTAAAAACAAACCTTTAGCAAGTGATGTTGATTTGCACAATGTTGCTACACAAACTCCAGGCTATGTCGGA
GCTGATTTGGAAAATGTTTTGAATGAAGCTGCACTTGTTGCTGCGCGCCAAAATAAAAAAGAAATCAATGCTGCTGACAT
TGATGAAGGAATGGACCGTGCAATGGCTGGTCCAGCTAAGAAAGATCGTATTCAATCAATGCGCGAACGTGAAATCGTGG
CTTACCACGAAGCAGGTCACGCTATTGTTGGACTCGTTCTTGAAAATGGATCTACTGTTCGTAAAGTTACCGTTGTTCCA
CGTGGACGCATCGGTGGTTACATGCTTGCTCTTCCAGATGAAGAAATCATGCAACCAACTAATTTCCATCTTCAAGACCA
ACTTGCCAGCCTTATGGGTGGACGACTTGGTGAAGAAATTGTCTTTGGTGTAGCTACTCCAGGGGCATCAAATGATATCG
AAAAAGCAACACACATTGCTCGTTCAATGGTAACTGAATATGGGATGTCTAAGAAACTTGGTATGGTATCTTATGAAGGA
GACCATCAAGTATTTATTGGTCGCGACTATGGTCAAACTAAGACTTACTCAGAAGCAACTGCTGTTATGATTGATGATGA
AGTGCGTCGTATTCTCGGTGAAGCTTATGACCGTGCTAAAGAAGCAATTGAAACACACCGTGAGCAACATAAAGCAATTG
CGGAAGCTCTGCTTAAATATGAAACACTTGATGCGAAACAAATCATGTCACTCTTCAAAACAGGAAAAATGCCTGATGAA
GCAGCGGCAGCAGAAGTACCAGAACCAAAAACATTTGAAGAATCTCTCAAAGATGCAAATGCGAATGTTGATGATTTTTC
AAACATTAATATCTATAATGGTGATGAAAAAACAGATTCTAAACCAGAAGAAAATAAGGAAAAATCAGAAGATGAAACAG
CCGAATAA

Upstream 100 bases:

>100_bases
TATAGCTGTTATTGACTAGCCTGTATCCTTTATTACCAGTGATACTAAGAAGTAAATTCTTGGCTTTTCTAATAATAAAT
AAACAAAAGATAAGGAAAAT

Downstream 100 bases:

>100_bases
GGCTGTTTTTCTTTTTTTTTATGTTTTAGAATAAGTGGTCTAGTTTATTCTTGACAAAAAATAATATTTTGATATAATTA
AATAGTTGTCGTTTGAGACG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MNNNKQPKQGNFVKNILMWVILAIVVVVGFNFFFSSNQSSVDKISYSQLMTKLDGNKIENVTMQPSDSLITVTGEYKEPV
KVKGTNNFPLLGNSSSEVKNFQAYIIPTDSVVKDIQNAAKSNDVKLSVVQASSSGMWVQILSYIIPMLLFVGIFWLMMGG
MGARGGGGGGNPMSFGKSRAKQQDGKTSKVRFADVAGSEEEKQELVEVVDFLKNPKKYHDLGARIPAGVLLEGPPGTGKT
LLAKAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFENAKKTAPSIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLL
VEMDGFQDDGNSVIVIAATNRSDVLDPALLRPGRFDRKVLVGAPDVKGREAVLKVHAKNKPLASDVDLHNVATQTPGYVG
ADLENVLNEAALVAARQNKKEINAADIDEGMDRAMAGPAKKDRIQSMREREIVAYHEAGHAIVGLVLENGSTVRKVTVVP
RGRIGGYMLALPDEEIMQPTNFHLQDQLASLMGGRLGEEIVFGVATPGASNDIEKATHIARSMVTEYGMSKKLGMVSYEG
DHQVFIGRDYGQTKTYSEATAVMIDDEVRRILGEAYDRAKEAIETHREQHKAIAEALLKYETLDAKQIMSLFKTGKMPDE
AAAAEVPEPKTFEESLKDANANVDDFSNINIYNGDEKTDSKPEENKEKSEDETAE

Sequences:

>Translated_695_residues
MNNNKQPKQGNFVKNILMWVILAIVVVVGFNFFFSSNQSSVDKISYSQLMTKLDGNKIENVTMQPSDSLITVTGEYKEPV
KVKGTNNFPLLGNSSSEVKNFQAYIIPTDSVVKDIQNAAKSNDVKLSVVQASSSGMWVQILSYIIPMLLFVGIFWLMMGG
MGARGGGGGGNPMSFGKSRAKQQDGKTSKVRFADVAGSEEEKQELVEVVDFLKNPKKYHDLGARIPAGVLLEGPPGTGKT
LLAKAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFENAKKTAPSIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLL
VEMDGFQDDGNSVIVIAATNRSDVLDPALLRPGRFDRKVLVGAPDVKGREAVLKVHAKNKPLASDVDLHNVATQTPGYVG
ADLENVLNEAALVAARQNKKEINAADIDEGMDRAMAGPAKKDRIQSMREREIVAYHEAGHAIVGLVLENGSTVRKVTVVP
RGRIGGYMLALPDEEIMQPTNFHLQDQLASLMGGRLGEEIVFGVATPGASNDIEKATHIARSMVTEYGMSKKLGMVSYEG
DHQVFIGRDYGQTKTYSEATAVMIDDEVRRILGEAYDRAKEAIETHREQHKAIAEALLKYETLDAKQIMSLFKTGKMPDE
AAAAEVPEPKTFEESLKDANANVDDFSNINIYNGDEKTDSKPEENKEKSEDETAE
>Mature_695_residues
MNNNKQPKQGNFVKNILMWVILAIVVVVGFNFFFSSNQSSVDKISYSQLMTKLDGNKIENVTMQPSDSLITVTGEYKEPV
KVKGTNNFPLLGNSSSEVKNFQAYIIPTDSVVKDIQNAAKSNDVKLSVVQASSSGMWVQILSYIIPMLLFVGIFWLMMGG
MGARGGGGGGNPMSFGKSRAKQQDGKTSKVRFADVAGSEEEKQELVEVVDFLKNPKKYHDLGARIPAGVLLEGPPGTGKT
LLAKAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFENAKKTAPSIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLL
VEMDGFQDDGNSVIVIAATNRSDVLDPALLRPGRFDRKVLVGAPDVKGREAVLKVHAKNKPLASDVDLHNVATQTPGYVG
ADLENVLNEAALVAARQNKKEINAADIDEGMDRAMAGPAKKDRIQSMREREIVAYHEAGHAIVGLVLENGSTVRKVTVVP
RGRIGGYMLALPDEEIMQPTNFHLQDQLASLMGGRLGEEIVFGVATPGASNDIEKATHIARSMVTEYGMSKKLGMVSYEG
DHQVFIGRDYGQTKTYSEATAVMIDDEVRRILGEAYDRAKEAIETHREQHKAIAEALLKYETLDAKQIMSLFKTGKMPDE
AAAAEVPEPKTFEESLKDANANVDDFSNINIYNGDEKTDSKPEENKEKSEDETAE

Specific function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein; Cytoplasmic side

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase M41 family

Homologues:

Organism=Homo sapiens, GI300192933, Length=539, Percent_Identity=45.8256029684601, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI21327685, Length=450, Percent_Identity=46.4444444444444, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI7657689, Length=450, Percent_Identity=46.4444444444444, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI4507173, Length=489, Percent_Identity=41.3087934560327, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI21361144, Length=242, Percent_Identity=42.9752066115703, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI4506209, Length=252, Percent_Identity=41.2698412698413, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI24497435, Length=249, Percent_Identity=41.3654618473896, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI24430151, Length=242, Percent_Identity=41.7355371900826, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI6005942, Length=249, Percent_Identity=43.7751004016064, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI45643123, Length=279, Percent_Identity=39.7849462365591, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI45643125, Length=279, Percent_Identity=39.7849462365591, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI5729991, Length=242, Percent_Identity=41.3223140495868, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI89064750, Length=242, Percent_Identity=41.3223140495868, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI24430155, Length=242, Percent_Identity=41.3223140495868, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI157671927, Length=230, Percent_Identity=42.1739130434783, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI195539395, Length=230, Percent_Identity=41.7391304347826, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI229577436, Length=248, Percent_Identity=40.7258064516129, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI40806173, Length=184, Percent_Identity=52.1739130434783, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI4505725, Length=224, Percent_Identity=40.625, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI153792536, Length=309, Percent_Identity=34.3042071197411, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI24497618, Length=304, Percent_Identity=36.1842105263158, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI194018488, Length=251, Percent_Identity=41.4342629482072, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI5901990, Length=236, Percent_Identity=40.2542372881356, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI14149767, Length=324, Percent_Identity=33.641975308642, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI62177112, Length=324, Percent_Identity=33.641975308642, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI226371754, Length=237, Percent_Identity=37.1308016877637, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI11875211, Length=238, Percent_Identity=40.3361344537815, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI40806170, Length=238, Percent_Identity=40.3361344537815, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI7019569, Length=238, Percent_Identity=36.5546218487395, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI17865802, Length=233, Percent_Identity=37.3390557939914, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI31377644, Length=234, Percent_Identity=38.034188034188, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI156564401, Length=237, Percent_Identity=34.5991561181435, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI310125282, Length=237, Percent_Identity=34.1772151898734, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI310125280, Length=231, Percent_Identity=34.1991341991342, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI31742536, Length=241, Percent_Identity=33.195020746888, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI112789543, Length=241, Percent_Identity=33.195020746888, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI64084766, Length=190, Percent_Identity=27.8947368421053, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI116292174, Length=225, Percent_Identity=29.3333333333333, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4757852, Length=161, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI119964730, Length=161, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789568, Length=623, Percent_Identity=46.8699839486356, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71994521, Length=455, Percent_Identity=49.8901098901099, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17554264, Length=482, Percent_Identity=44.3983402489627, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI115534323, Length=464, Percent_Identity=43.9655172413793, Blast_Score=349, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17554786, Length=249, Percent_Identity=43.3734939759036, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25144281, Length=249, Percent_Identity=42.9718875502008, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI25144278, Length=249, Percent_Identity=42.9718875502008, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17563248, Length=252, Percent_Identity=43.2539682539683, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17505546, Length=251, Percent_Identity=43.0278884462151, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17563250, Length=243, Percent_Identity=41.9753086419753, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17508701, Length=252, Percent_Identity=40.8730158730159, Blast_Score=192, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17532375, Length=254, Percent_Identity=38.5826771653543, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71987364, Length=255, Percent_Identity=40.7843137254902, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71987372, Length=255, Percent_Identity=40.7843137254902, Blast_Score=185, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17531535, Length=258, Percent_Identity=39.5348837209302, Blast_Score=182, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17554784, Length=254, Percent_Identity=40.9448818897638, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17508053, Length=231, Percent_Identity=41.991341991342, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25153574, Length=229, Percent_Identity=37.9912663755458, Blast_Score=159, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17537217, Length=195, Percent_Identity=44.6153846153846, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193209502, Length=229, Percent_Identity=37.9912663755458, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI133931034, Length=280, Percent_Identity=36.7857142857143, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI193206114, Length=280, Percent_Identity=36.7857142857143, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI193206116, Length=280, Percent_Identity=36.7857142857143, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17570397, Length=165, Percent_Identity=44.8484848484849, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32566590, Length=165, Percent_Identity=44.8484848484849, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562804, Length=235, Percent_Identity=36.5957446808511, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI25146157, Length=235, Percent_Identity=39.5744680851064, Blast_Score=132, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI86561515, Length=258, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17508421, Length=244, Percent_Identity=36.0655737704918, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI133901658, Length=214, Percent_Identity=36.9158878504673, Blast_Score=126, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI133901662, Length=213, Percent_Identity=36.150234741784, Blast_Score=126, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32563584, Length=228, Percent_Identity=37.280701754386, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17541224, Length=193, Percent_Identity=37.3056994818653, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17541226, Length=193, Percent_Identity=37.3056994818653, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560432, Length=241, Percent_Identity=33.6099585062241, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323736, Length=553, Percent_Identity=45.3887884267631, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320854, Length=540, Percent_Identity=43.5185185185185, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6325281, Length=459, Percent_Identity=41.8300653594771, Blast_Score=356, Evalue=8e-99,
Organism=Saccharomyces cerevisiae, GI6321390, Length=242, Percent_Identity=41.7355371900826, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320197, Length=251, Percent_Identity=41.0358565737052, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320077, Length=250, Percent_Identity=43.2, Blast_Score=197, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6322704, Length=249, Percent_Identity=40.9638554216867, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324691, Length=271, Percent_Identity=39.4833948339483, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324833, Length=240, Percent_Identity=41.6666666666667, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320602, Length=243, Percent_Identity=42.3868312757202, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6323429, Length=232, Percent_Identity=41.3793103448276, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324000, Length=242, Percent_Identity=38.8429752066116, Blast_Score=163, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6321709, Length=263, Percent_Identity=38.4030418250951, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322994, Length=233, Percent_Identity=36.9098712446352, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322651, Length=258, Percent_Identity=35.6589147286822, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325431, Length=242, Percent_Identity=37.1900826446281, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321465, Length=247, Percent_Identity=37.246963562753, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325183, Length=256, Percent_Identity=36.71875, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319554, Length=217, Percent_Identity=35.9447004608295, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320887, Length=259, Percent_Identity=35.5212355212355, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320583, Length=189, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24665814, Length=487, Percent_Identity=47.2279260780287, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI28574878, Length=464, Percent_Identity=48.4913793103448, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24658770, Length=501, Percent_Identity=43.7125748502994, Blast_Score=394, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24639391, Length=483, Percent_Identity=45.1345755693582, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19920408, Length=249, Percent_Identity=41.3654618473896, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17137738, Length=252, Percent_Identity=42.4603174603175, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI161076486, Length=227, Percent_Identity=42.2907488986784, Blast_Score=197, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24651451, Length=249, Percent_Identity=41.7670682730924, Blast_Score=197, Evalue=3e-50,
Organism=Drosophila melanogaster, GI161076488, Length=227, Percent_Identity=42.2907488986784, Blast_Score=197, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137560, Length=227, Percent_Identity=42.2907488986784, Blast_Score=197, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45554047, Length=166, Percent_Identity=60.2409638554217, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24649446, Length=237, Percent_Identity=42.6160337552743, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281361487, Length=242, Percent_Identity=42.1487603305785, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17738151, Length=252, Percent_Identity=40.4761904761905, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281365776, Length=231, Percent_Identity=44.5887445887446, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24660075, Length=231, Percent_Identity=44.5887445887446, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI45552965, Length=242, Percent_Identity=43.801652892562, Blast_Score=192, Evalue=9e-49,
Organism=Drosophila melanogaster, GI18860063, Length=249, Percent_Identity=42.1686746987952, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19921202, Length=232, Percent_Identity=40.5172413793103, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24652279, Length=190, Percent_Identity=44.7368421052632, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24640100, Length=238, Percent_Identity=40.3361344537815, Blast_Score=176, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24663015, Length=232, Percent_Identity=40.948275862069, Blast_Score=172, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24656820, Length=264, Percent_Identity=39.0151515151515, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24656825, Length=264, Percent_Identity=39.0151515151515, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281363136, Length=240, Percent_Identity=39.5833333333333, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI78707192, Length=240, Percent_Identity=39.5833333333333, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24644145, Length=243, Percent_Identity=38.6831275720165, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18859657, Length=234, Percent_Identity=39.3162393162393, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28571849, Length=246, Percent_Identity=39.0243902439024, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28571847, Length=246, Percent_Identity=39.0243902439024, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21355121, Length=235, Percent_Identity=34.8936170212766, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360136, Length=242, Percent_Identity=36.7768595041322, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24644411, Length=242, Percent_Identity=36.7768595041322, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI281360144, Length=242, Percent_Identity=36.7768595041322, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI281360140, Length=242, Percent_Identity=36.7768595041322, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI281360142, Length=242, Percent_Identity=36.7768595041322, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357333, Length=242, Percent_Identity=36.7768595041322, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI281360146, Length=242, Percent_Identity=36.7768595041322, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI281360138, Length=242, Percent_Identity=36.7768595041322, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20129423, Length=240, Percent_Identity=35.4166666666667, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI20129529, Length=242, Percent_Identity=34.297520661157, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28573010, Length=238, Percent_Identity=34.8739495798319, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17864540, Length=213, Percent_Identity=36.150234741784, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581396, Length=238, Percent_Identity=36.1344537815126, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24639486, Length=205, Percent_Identity=34.6341463414634, Blast_Score=106, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTSH_LACLA (P46469)

Other databases:

- EMBL:   X69123
- EMBL:   AE005176
- EMBL:   X67015
- PIR:   E86627
- PIR:   S28533
- RefSeq:   NP_266177.1
- ProteinModelPortal:   P46469
- MEROPS:   M41.009
- PhosSite:   P46469
- GeneID:   1113620
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0204
- NMPDR:   fig|272623.1.peg.22
- HOGENOM:   HBG724153
- OMA:   IDILATN
- ProtClustDB:   CLSK696969
- BioCyc:   LLAC272623:L0204-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01458
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR005936
- InterPro:   IPR011546
- InterPro:   IPR000642
- SMART:   SM00382
- TIGRFAMs:   TIGR01241

Pfam domain/function: PF00004 AAA; PF06480 FtsH_ext; PF01434 Peptidase_M41

EC number: 3.4.24.-

Molecular weight: Translated: 75562; Mature: 75562

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00674 AAA

Important sites: ACT_SITE 457-457

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xbc46b20)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNKQPKQGNFVKNILMWVILAIVVVVGFNFFFSSNQSSVDKISYSQLMTKLDGNKIEN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCE
VTMQPSDSLITVTGEYKEPVKVKGTNNFPLLGNSSSEVKNFQAYIIPTDSVVKDIQNAAK
EEECCCCCEEEEECCCCCCEEEECCCCCCEECCCHHHHCCEEEEEECCHHHHHHHHHHHC
SNDVKLSVVQASSSGMWVQILSYIIPMLLFVGIFWLMMGGMGARGGGGGGNPMSFGKSRA
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
KQQDGKTSKVRFADVAGSEEEKQELVEVVDFLKNPKKYHDLGARIPAGVLLEGPPGTGKT
HHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCCHH
LLAKAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFENAKKTAPSIIFIDEIDAVGRQ
HHHHHHCCCCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHH
RGAGLGGGNDEREQTLNQLLVEMDGFQDDGNSVIVIAATNRSDVLDPALLRPGRFDRKVL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCEEE
VGAPDVKGREAVLKVHAKNKPLASDVDLHNVATQTPGYVGADLENVLNEAALVAARQNKK
EECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCH
EINAADIDEGMDRAMAGPAKKDRIQSMREREIVAYHEAGHAIVGLVLENGSTVRKVTVVP
HCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEEEECCCCEEEEEEEECCCCEEEEEEEE
RGRIGGYMLALPDEEIMQPTNFHLQDQLASLMGGRLGEEIVFGVATPGASNDIEKATHIA
CCCCCCEEEECCCHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
RSMVTEYGMSKKLGMVSYEGDHQVFIGRDYGQTKTYSEATAVMIDDEVRRILGEAYDRAK
HHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
EAIETHREQHKAIAEALLKYETLDAKQIMSLFKTGKMPDEAAAAEVPEPKTFEESLKDAN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHCC
ANVDDFSNINIYNGDEKTDSKPEENKEKSEDETAE
CCCCCCCCCEEECCCCCCCCCCCCHHHCCCCCCCH
>Mature Secondary Structure
MNNNKQPKQGNFVKNILMWVILAIVVVVGFNFFFSSNQSSVDKISYSQLMTKLDGNKIEN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCE
VTMQPSDSLITVTGEYKEPVKVKGTNNFPLLGNSSSEVKNFQAYIIPTDSVVKDIQNAAK
EEECCCCCEEEEECCCCCCEEEECCCCCCEECCCHHHHCCEEEEEECCHHHHHHHHHHHC
SNDVKLSVVQASSSGMWVQILSYIIPMLLFVGIFWLMMGGMGARGGGGGGNPMSFGKSRA
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
KQQDGKTSKVRFADVAGSEEEKQELVEVVDFLKNPKKYHDLGARIPAGVLLEGPPGTGKT
HHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCCHH
LLAKAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFENAKKTAPSIIFIDEIDAVGRQ
HHHHHHCCCCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHH
RGAGLGGGNDEREQTLNQLLVEMDGFQDDGNSVIVIAATNRSDVLDPALLRPGRFDRKVL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCEEE
VGAPDVKGREAVLKVHAKNKPLASDVDLHNVATQTPGYVGADLENVLNEAALVAARQNKK
EECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCH
EINAADIDEGMDRAMAGPAKKDRIQSMREREIVAYHEAGHAIVGLVLENGSTVRKVTVVP
HCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEEEECCCCEEEEEEEECCCCEEEEEEEE
RGRIGGYMLALPDEEIMQPTNFHLQDQLASLMGGRLGEEIVFGVATPGASNDIEKATHIA
CCCCCCEEEECCCHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
RSMVTEYGMSKKLGMVSYEGDHQVFIGRDYGQTKTYSEATAVMIDDEVRRILGEAYDRAK
HHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
EAIETHREQHKAIAEALLKYETLDAKQIMSLFKTGKMPDEAAAAEVPEPKTFEESLKDAN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHCC
ANVDDFSNINIYNGDEKTDSKPEENKEKSEDETAE
CCCCCCCCCEEECCCCCCCCCCCCHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8000529; 11337471; 1465108