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The map label for this gene is hpt

Identifier: 15672002

GI number: 15672002

Start: 25130

End: 25681

Strand: Direct

Name: hpt

Synonym: L25115

Alternate gene names: 15672002

Gene position: 25130-25681 (Clockwise)

Preceding gene: 15672001

Following gene: 15672003

Centisome position: 1.06

GC content: 31.7

Gene sequence:

>552_bases
ATGCTCGAAAAAAATCTTGATAAGGCCATTGAAAAAGTATTAGTTTCAGAAGAAGAAATTATAGAAAAATCCAAAGAACT
TGGAGAAATATTAACAAAAGAATACGAAGGAAAAAATCCATTAGTCTTAGGAATTCTTCGCGGTTCAGTTCCTTTCTTAG
CTGAATTAATCAAACATATTGATTGTCACTTAGAAACTGACTTTATGACTGTATCAAGTTATCACGGCGGAACAAAATCC
TCTGGTGAAGTAAAATTAATCCTAGATGTTGATACAGCAGTCAAAGGTCGTGATATTTTAATTGTTGAAGATATTATCGA
TACTGGTCGTACTTTAAAATATCTAAAAGAACTTTTGGAACATCGTGGGGCAAACGTAAAAATTGTAACACTTCTTGACA
AACCAGAAGGACGAATTGTTGAAATTAAACCAGATTATTCAGGTTTTACAATTCCTAATGAATTTGTTGTTGGATTTGGT
TTGGACTACGAAGAAAACTATCGTAATCTTCCATATGTCGGAGTTTTAAAACCAGAAGTTTATAACAAATAA

Upstream 100 bases:

>100_bases
ATTGTCGGTCTTGCGTGTTCTGATTTGAGTAAAATGCTCAAAAATGATAAAATTAGAAGAATATTATGGGTCAAACCCAG
TATAGGAGAGGAAATCAACG

Downstream 100 bases:

>100_bases
TTCGTTGATTTTAGTCATCTAAAATTTTTCTCAGACTAAAGTATGAAAAAATCTCTGACCAATACTTACTATTAGCATTC
CAAAAGGAAATATGCTATAA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLEKNLDKAIEKVLVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHIDCHLETDFMTVSSYHGGTKS
SGEVKLILDVDTAVKGRDILIVEDIIDTGRTLKYLKELLEHRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFG
LDYEENYRNLPYVGVLKPEVYNK

Sequences:

>Translated_183_residues
MLEKNLDKAIEKVLVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHIDCHLETDFMTVSSYHGGTKS
SGEVKLILDVDTAVKGRDILIVEDIIDTGRTLKYLKELLEHRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFG
LDYEENYRNLPYVGVLKPEVYNK
>Mature_183_residues
MLEKNLDKAIEKVLVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHIDCHLETDFMTVSSYHGGTKS
SGEVKLILDVDTAVKGRDILIVEDIIDTGRTLKYLKELLEHRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFG
LDYEENYRNLPYVGVLKPEVYNK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4504483, Length=178, Percent_Identity=35.3932584269663, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI9910262, Length=179, Percent_Identity=34.0782122905028, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=44.578313253012, Blast_Score=150, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17510817, Length=181, Percent_Identity=30.939226519337, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_LACLA (Q02522)

Other databases:

- EMBL:   X67015
- EMBL:   X69123
- EMBL:   AE005176
- PIR:   D86627
- PIR:   S30100
- RefSeq:   NP_266176.1
- ProteinModelPortal:   Q02522
- SMR:   Q02522
- GeneID:   1113619
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L25115
- NMPDR:   fig|272623.1.peg.21
- HOGENOM:   HBG536385
- OMA:   INAHYAD
- ProtClustDB:   CLSK696968
- BioCyc:   LLAC272623:L25115-MONOMER
- BRENDA:   2.4.2.8
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20648; Mature: 20648

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKNLDKAIEKVLVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
DCHLETDFMTVSSYHGGTKSSGEVKLILDVDTAVKGRDILIVEDIIDTGRTLKYLKELLE
HCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHHHH
HRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFGLDYEENYRNLPYVGVLKPEV
HCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEECCHH
YNK
CCC
>Mature Secondary Structure
MLEKNLDKAIEKVLVSEEEIIEKSKELGEILTKEYEGKNPLVLGILRGSVPFLAELIKHI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
DCHLETDFMTVSSYHGGTKSSGEVKLILDVDTAVKGRDILIVEDIIDTGRTLKYLKELLE
HCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEEHHHHCCCHHHHHHHHHHH
HRGANVKIVTLLDKPEGRIVEIKPDYSGFTIPNEFVVGFGLDYEENYRNLPYVGVLKPEV
HCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEECCHH
YNK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1465108; 11337471