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The map label for this gene is rpiA

Identifier: 15669799

GI number: 15669799

Start: 1576607

End: 1577287

Strand: Direct

Name: rpiA

Synonym: MJ1603

Alternate gene names: 15669799

Gene position: 1576607-1577287 (Clockwise)

Preceding gene: 15669798

Following gene: 15669803

Centisome position: 94.69

GC content: 33.48

Gene sequence:

>681_bases
GTGTCAAATGAAGATTTAAAATTAAAAGTAGCTAAGGAAGCAGTGAAGTTAGTTAAAGATGGAATGGTTATTGGATTAGG
AACCGGTTCAACAGCAGCTTTATTCATCAGAGAACTTGGAAATAGAATTAGAGAAGAGGAGCTAACAGTCTTCGGAATTC
CAACATCATTTGAAGCTAAAATGCTGGCTATGCAGTATGAAATTCCATTAGTTACATTAGATGAGTACGATGTTGATATT
GCCTTTGATGGAGCTGATGAAGTTGAGGAAACAACTCTCTTTTTAATAAAAGGAGGTGGAGGCTGCCATACTCAAGAAAA
AATAGTTGATTACAACGCAAATGAATTTGTTGTTTTAGTTGATGAAAGTAAATTAGTTAAAAAATTAGGGGAAAAGTTCC
CAATCCCTGTGGAAGTTATTCCTTCAGCTTATAGGGTTGTAATAAGAGCTTTATCAGAAATGGGAGGAGAGGCAGTAATT
AGATTAGGAGACAGAAAAAGAGGACCTGTTATAACAGACAACGGAAATATGATTATTGATGTATTTATGAACATAGATGA
CGCTATAGAACTTGAGAAAGAAATTAATAACATTCCTGGAGTAGTTGAAAATGGTATCTTTACAAAGGTAGATAAGGTTT
TAGTTGGAACTAAAAAAGGAGTAAAAACACTTAAAAAATAA

Upstream 100 bases:

>100_bases
TGATGCCAAAGGCATCTTTTTACATTAAATAATATCTTATCCTCTGTGAAAGTCCTGTAATATTTCAATAACAACCACAA
AGCCAGAAAAGAGGGATATA

Downstream 100 bases:

>100_bases
AAAATTAGTTTTTAGCTCATTCTTTTTTTATTTAATAGAGATACATAATAAACAAACGCCCCACTTGATATTGTATCTCC
TAAACCTACTGTAGATTTTG

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSNEDLKLKVAKEAVKLVKDGMVIGLGTGSTAALFIRELGNRIREEELTVFGIPTSFEAKMLAMQYEIPLVTLDEYDVDI
AFDGADEVEETTLFLIKGGGGCHTQEKIVDYNANEFVVLVDESKLVKKLGEKFPIPVEVIPSAYRVVIRALSEMGGEAVI
RLGDRKRGPVITDNGNMIIDVFMNIDDAIELEKEINNIPGVVENGIFTKVDKVLVGTKKGVKTLKK

Sequences:

>Translated_226_residues
MSNEDLKLKVAKEAVKLVKDGMVIGLGTGSTAALFIRELGNRIREEELTVFGIPTSFEAKMLAMQYEIPLVTLDEYDVDI
AFDGADEVEETTLFLIKGGGGCHTQEKIVDYNANEFVVLVDESKLVKKLGEKFPIPVEVIPSAYRVVIRALSEMGGEAVI
RLGDRKRGPVITDNGNMIIDVFMNIDDAIELEKEINNIPGVVENGIFTKVDKVLVGTKKGVKTLKK
>Mature_225_residues
SNEDLKLKVAKEAVKLVKDGMVIGLGTGSTAALFIRELGNRIREEELTVFGIPTSFEAKMLAMQYEIPLVTLDEYDVDIA
FDGADEVEETTLFLIKGGGGCHTQEKIVDYNANEFVVLVDESKLVKKLGEKFPIPVEVIPSAYRVVIRALSEMGGEAVIR
LGDRKRGPVITDNGNMIIDVFMNIDDAIELEKEINNIPGVVENGIFTKVDKVLVGTKKGVKTLKK

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=234, Percent_Identity=41.4529914529915, Blast_Score=160, Evalue=9e-40,
Organism=Escherichia coli, GI1789280, Length=230, Percent_Identity=43.4782608695652, Blast_Score=140, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17551758, Length=214, Percent_Identity=36.9158878504673, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324669, Length=234, Percent_Identity=38.8888888888889, Blast_Score=125, Evalue=4e-30,
Organism=Drosophila melanogaster, GI281364072, Length=216, Percent_Identity=38.4259259259259, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_METJA (Q58998)

Other databases:

- EMBL:   L77117
- PIR:   B64500
- RefSeq:   NP_248613.1
- PDB:   3IXQ
- PDBsum:   3IXQ
- ProteinModelPortal:   Q58998
- SMR:   Q58998
- GeneID:   1452512
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1603
- NMPDR:   fig|243232.1.peg.1650
- TIGR:   MJ1603
- HOGENOM:   HBG515603
- OMA:   VFDLNSV
- ProtClustDB:   PRK00702
- BioCyc:   MJAN243232:MJ_1603-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR014036
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF00455 DeoR; PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 24830; Mature: 24699

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEDLKLKVAKEAVKLVKDGMVIGLGTGSTAALFIRELGNRIREEELTVFGIPTSFEAK
CCCCCEEEEHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCE
MLAMQYEIPLVTLDEYDVDIAFDGADEVEETTLFLIKGGGGCHTQEKIVDYNANEFVVLV
EEEEEECCCEEEECCCCEEEEECCCCCCCCEEEEEEECCCCCCCCHHHEECCCCEEEEEE
DESKLVKKLGEKFPIPVEVIPSAYRVVIRALSEMGGEAVIRLGDRKRGPVITDNGNMIID
CCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCEEEE
VFMNIDDAIELEKEINNIPGVVENGIFTKVDKVLVGTKKGVKTLKK
EEECCCHHHHHHHHHCCCCCHHCCCCHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure 
SNEDLKLKVAKEAVKLVKDGMVIGLGTGSTAALFIRELGNRIREEELTVFGIPTSFEAK
CCCCEEEEHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCE
MLAMQYEIPLVTLDEYDVDIAFDGADEVEETTLFLIKGGGGCHTQEKIVDYNANEFVVLV
EEEEEECCCEEEECCCCEEEEECCCCCCCCEEEEEEECCCCCCCCHHHEECCCCEEEEEE
DESKLVKKLGEKFPIPVEVIPSAYRVVIRALSEMGGEAVIRLGDRKRGPVITDNGNMIID
CCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCEEEE
VFMNIDDAIELEKEINNIPGVVENGIFTKVDKVLVGTKKGVKTLKK
EEECCCHHHHHHHHHCCCCCHHCCCCHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087