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The map label for this gene is hom

Identifier: 15669798

GI number: 15669798

Start: 1574035

End: 1575045

Strand: Direct

Name: hom

Synonym: MJ1602

Alternate gene names: 15669798

Gene position: 1574035-1575045 (Clockwise)

Preceding gene: 15669797

Following gene: 15669799

Centisome position: 94.54

GC content: 32.54

Gene sequence:

>1011_bases
ATGGATATAATTATAGTAGGATTTGGAGCTATAGGAAAAGGAATTGCTAAGGTCTTGTATGATAAAAAAGATTATTTAAA
AAAGAACTATGAGGAATTTAAGGTTGTTGCTATAACAGATAGCTCTGGAGCTGCAATAGATGAAGATGGCTTAGATTTAC
TAAAAGCAATAGAAGTTAAAGAAAAAACTGGAAAGATTAAAAATTATCCAGAGAAAGGAAGAGAGATGAGTTCAATAGAT
GTTATAAAAGAAGTTGATGCGGATGTTGTTGTTGAAGTAACACCATCAAACTTAGAAACAGGAGACCCAGCTAAAACTCA
TATATTAGAAAGCTTTAAAAATAAAAAACACGTTGTAACAGCTAATAAAGGACCGTTAGCTTTATGTTATAAGGAGTTGA
TTGAAGAGGCAAAAAAACATGGAGTTATTTTCAGACATGAGGCTTCAGTTGGAGGGGCAATGCCAATAATAAACTTGGCT
AAAGAGACATTAGCAGGAAATGAAATTTTATCAATAAGGGGAATTTTAAATGGAACAACCAACTACATACTAACAAAAAT
GGAGAAAGAGGGTTTAGATTTTGAAACTGCATTAAAAGAGGCTAAAGAGCTTGGAATAGCTGAAACAGACCCAACTCAAG
ATATTGAGGGTTTAGACACTGCAGCAAAGATTGTTATCTTAGCAAACTCAATTATGGGCATGAATAAAACAATAAAAGAT
GTAAAAGTTAAGGGAATAAGTAGAATAACTCCAGAAGCTCTATTTTTAGCTAATAAAAGAGGATACACAATAAAATTAAT
TGGACAGATTAAAGATGGCTATTTAATTGTTGAGCCAATGCTTGTTCCAATAGACAGCCCATTAAATGTCAAGGGAACTT
TAAACGTTGCAATGTTTGAAACTGATTTGGCAAAAGAGGTTGTAGTTGTTGGAAGAGGAGCTGGACCTATAGAAACAGCT
TCAGCTATTTTAAGTGATTTAATCCATATCTACAATTCTACTAAAAAATAA

Upstream 100 bases:

>100_bases
GATAAGATAGAGGAGCTTTTTTACTTATTTGAAGAGTTAGAAAAAGAAAAAGGATTGTTATTCATAAAATCCATATTTTA
AATAAAATTTTGGTGAGAGG

Downstream 100 bases:

>100_bases
TTTAATTTTTTGTGTTACATATTTATATGGGTTCCGTAGATATTATATTTTAGAATTTTACTATTAAGGTTTTTATGGGA
TTTTCAATTTTGTTAATTGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDIIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVKEKTGKIKNYPEKGREMSSID
VIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVTANKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLA
KETLAGNEILSIRGILNGTTNYILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKD
VKVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFETDLAKEVVVVGRGAGPIETA
SAILSDLIHIYNSTKK

Sequences:

>Translated_336_residues
MDIIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVKEKTGKIKNYPEKGREMSSID
VIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVTANKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLA
KETLAGNEILSIRGILNGTTNYILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKD
VKVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFETDLAKEVVVVGRGAGPIETA
SAILSDLIHIYNSTKK
>Mature_336_residues
MDIIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVKEKTGKIKNYPEKGREMSSID
VIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVTANKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLA
KETLAGNEILSIRGILNGTTNYILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKD
VKVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFETDLAKEVVVVGRGAGPIETA
SAILSDLIHIYNSTKK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786183, Length=342, Percent_Identity=28.0701754385965, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790376, Length=356, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=122, Percent_Identity=33.6065573770492, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHOM_METJA (Q58997)

Other databases:

- EMBL:   L77117
- PIR:   A64500
- RefSeq:   NP_248612.1
- ProteinModelPortal:   Q58997
- SMR:   Q58997
- GeneID:   1452511
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1602
- NMPDR:   fig|243232.1.peg.1649
- TIGR:   MJ1602
- HOGENOM:   HBG527379
- OMA:   HVVTTNK
- ProtClustDB:   PRK06270
- BioCyc:   MJAN243232:MJ_1602-MONOMER
- BRENDA:   1.1.1.3
- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF036497

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3

EC number: =1.1.1.3

Molecular weight: Translated: 36463; Mature: 36463

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: ACT_SITE 223-223 BINDING 94-94 BINDING 123-123 BINDING 208-208

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVK
CEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCCEECCCHHHHHHHHHHH
EKTGKIKNYPEKGREMSSIDVIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVT
HHCCCCCCCCHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEE
ANKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLAKETLAGNEILSIRGILNGTT
ECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
NYILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKD
HHEEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEHHHHCCCCHHHH
VKVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFE
HHCCCCCCCCCHHEEEECCCCCEEEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEEEEE
TDLAKEVVVVGRGAGPIETASAILSDLIHIYNSTKK
HHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDIIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVK
CEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCCEECCCHHHHHHHHHHH
EKTGKIKNYPEKGREMSSIDVIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVT
HHCCCCCCCCHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEE
ANKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLAKETLAGNEILSIRGILNGTT
ECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
NYILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKD
HHEEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEHHHHCCCCHHHH
VKVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFE
HHCCCCCCCCCHHEEEECCCCCEEEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEEEEE
TDLAKEVVVVGRGAGPIETASAILSDLIHIYNSTKK
HHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087