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The map label for this gene is aroD

Identifier: 15669645

GI number: 15669645

Start: 1423963

End: 1424625

Strand: Reverse

Name: aroD

Synonym: MJ1454

Alternate gene names: 15669645

Gene position: 1424625-1423963 (Counterclockwise)

Preceding gene: 15669646

Following gene: 15669614

Centisome position: 85.56

GC content: 30.62

Gene sequence:

>663_bases
ATGATATGTTTGCCAGTAGTTGAAGATAGTGTAGAAAAAGCAATAAAAACAGCTGAAAAGTATTTAGAAATAGCAGATAT
TGTTGAATTTAGGATAGATATGCTTAAAGAAGTTAGTGAAGAAGATATAGAGAAATTTGCTAAGTATCCTTGCATAATAA
CTGTTAGAGCAGATTGGGAGGGTGGTTATTGGAAGGGAAATAATGAGGAAAGATTAAACTTAATAAAAAAGGCAATTGAA
TGCAATGCCAAATTTGTTGATATTGAATTGAGAGAGGAGAAAAATAAAGAACTTGTAAAATTTAGAGATGAAATTGGTTC
AAAAACAAAAATTATAATTTCTTATCATGATTTTGAAAAAACTCCTTCTAAGGAAAAATTGGTAGAGATTGTTGAAAAAG
CTCTTAGCATTGGAGATATAGCAAAATTTGCAACAATGGCAAATAGTAAAGAAGATGTCCTCAATATCTTAGAAGTGATA
AATAAATATCCTGGAAAGATTATTGGTATTGGAATGGGCGAGAAAGGGAAACTAACAAGAATCTTAGGGGTTTATTTTGG
CTCAATATTAACGTTTGCTTCATATAAAGGGAAAAGTTCTGCCCCTGGGCAGGTTGATATTGATACATTAAAAGAAATCT
GGAGACTAATGGATTTAAAGTAA

Upstream 100 bases:

>100_bases
AATAAATTTTCTATTTTTTAGCTTAATTTTATATTGCATTAAATTTAAAATATTTTGCTTTTTAATTTTTAATTAAATAA
AACTTTTAAGGGGAGAGAAT

Downstream 100 bases:

>100_bases
ATTTAAATTTCTTAGCATAATTTCAGCTAATTGTTTATGTTCTCTACCTCCAACTTTTTTAATTATTGAGAAATATTTTC
TAATGTCATTTATCATCTCT

Product: 3-dehydroquinate dehydratase AroD

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MICLPVVEDSVEKAIKTAEKYLEIADIVEFRIDMLKEVSEEDIEKFAKYPCIITVRADWEGGYWKGNNEERLNLIKKAIE
CNAKFVDIELREEKNKELVKFRDEIGSKTKIIISYHDFEKTPSKEKLVEIVEKALSIGDIAKFATMANSKEDVLNILEVI
NKYPGKIIGIGMGEKGKLTRILGVYFGSILTFASYKGKSSAPGQVDIDTLKEIWRLMDLK

Sequences:

>Translated_220_residues
MICLPVVEDSVEKAIKTAEKYLEIADIVEFRIDMLKEVSEEDIEKFAKYPCIITVRADWEGGYWKGNNEERLNLIKKAIE
CNAKFVDIELREEKNKELVKFRDEIGSKTKIIISYHDFEKTPSKEKLVEIVEKALSIGDIAKFATMANSKEDVLNILEVI
NKYPGKIIGIGMGEKGKLTRILGVYFGSILTFASYKGKSSAPGQVDIDTLKEIWRLMDLK
>Mature_220_residues
MICLPVVEDSVEKAIKTAEKYLEIADIVEFRIDMLKEVSEEDIEKFAKYPCIITVRADWEGGYWKGNNEERLNLIKKAIE
CNAKFVDIELREEKNKELVKFRDEIGSKTKIIISYHDFEKTPSKEKLVEIVEKALSIGDIAKFATMANSKEDVLNILEVI
NKYPGKIIGIGMGEKGKLTRILGVYFGSILTFASYKGKSSAPGQVDIDTLKEIWRLMDLK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=210, Percent_Identity=31.9047619047619, Blast_Score=93, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_METJA (Q58849)

Other databases:

- EMBL:   L77117
- PIR:   E64481
- RefSeq:   NP_248458.1
- ProteinModelPortal:   Q58849
- SMR:   Q58849
- GeneID:   1452358
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1454
- NMPDR:   fig|243232.1.peg.1495
- TIGR:   MJ1454
- HOGENOM:   HBG732926
- OMA:   NHDFDKT
- ProtClustDB:   CLSK876583
- BioCyc:   MJAN243232:MJ_1454-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR018508
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 25045; Mature: 25045

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 116-116 ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICLPVVEDSVEKAIKTAEKYLEIADIVEFRIDMLKEVSEEDIEKFAKYPCIITVRADWE
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEECCC
GGYWKGNNEERLNLIKKAIECNAKFVDIELREEKNKELVKFRDEIGSKTKIIISYHDFEK
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCC
TPSKEKLVEIVEKALSIGDIAKFATMANSKEDVLNILEVINKYPGKIIGIGMGEKGKLTR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
ILGVYFGSILTFASYKGKSSAPGQVDIDTLKEIWRLMDLK
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MICLPVVEDSVEKAIKTAEKYLEIADIVEFRIDMLKEVSEEDIEKFAKYPCIITVRADWE
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEECCC
GGYWKGNNEERLNLIKKAIECNAKFVDIELREEKNKELVKFRDEIGSKTKIIISYHDFEK
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCC
TPSKEKLVEIVEKALSIGDIAKFATMANSKEDVLNILEVINKYPGKIIGIGMGEKGKLTR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
ILGVYFGSILTFASYKGKSSAPGQVDIDTLKEIWRLMDLK
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087