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The map label for this gene is hisI

Identifier: 15669621

GI number: 15669621

Start: 1400929

End: 1401312

Strand: Direct

Name: hisI

Synonym: MJ1430

Alternate gene names: 15669621

Gene position: 1400929-1401312 (Clockwise)

Preceding gene: 15669620

Following gene: 15669622

Centisome position: 84.14

GC content: 28.91

Gene sequence:

>384_bases
ATGGATGTGGAAGATACTGTTAAAAAACTAAATTTAAAATTCAGAAATATAGAAGGAGAGAGATTAATTTTAGCAATAAC
CTGTGATGAGAATAAAAATGTGTTAATGGTTGCATTTATGAATGAAGAGGCATTAAAAAAGACATTAGAAACTGGATATA
TGCATTATTATTCAACAAGTAGAAAAAAGTTATGGAGAAAAGGAGAAGAGAGTGGAAATGTTCAAAAATTAATAAAATTT
TATAGGGACTGTGATGGAGACGCTTTATTATTTATAGTTGAACAGAAAGGGGTTGCATGTCATGAGGGTTATTATTCATG
TTTCCATTATAAAATAGAAGATGGAGAACTAAAAATAACTGGAGAATACTACTCTAAGAGATGA

Upstream 100 bases:

>100_bases
GATGATTGGTAACCATAGGAGGAAACCTCCTATTGGTATACCACCCGTCTATTAAGTTAGGACTTTCAGTCCTAATTAAT
ATCCATATTTAGGTGATTTC

Downstream 100 bases:

>100_bases
GAATATGGACCCAAATAAATTTAGAGAGAAAGAAATATCCAAAAAAGAAGCATTAGAGTTATTTGAAGATAATGAGATTA
TATTTGAGTTGTTTAAATTT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MDVEDTVKKLNLKFRNIEGERLILAITCDENKNVLMVAFMNEEALKKTLETGYMHYYSTSRKKLWRKGEESGNVQKLIKF
YRDCDGDALLFIVEQKGVACHEGYYSCFHYKIEDGELKITGEYYSKR

Sequences:

>Translated_127_residues
MDVEDTVKKLNLKFRNIEGERLILAITCDENKNVLMVAFMNEEALKKTLETGYMHYYSTSRKKLWRKGEESGNVQKLIKF
YRDCDGDALLFIVEQKGVACHEGYYSCFHYKIEDGELKITGEYYSKR
>Mature_127_residues
MDVEDTVKKLNLKFRNIEGERLILAITCDENKNVLMVAFMNEEALKKTLETGYMHYYSTSRKKLWRKGEESGNVQKLIKF
YRDCDGDALLFIVEQKGVACHEGYYSCFHYKIEDGELKITGEYYSKR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=75, Percent_Identity=46.6666666666667, Blast_Score=85, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=88, Percent_Identity=42.0454545454545, Blast_Score=74, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_METJA (Q58825)

Other databases:

- EMBL:   L77117
- PIR:   E64478
- RefSeq:   NP_248434.1
- ProteinModelPortal:   Q58825
- SMR:   Q58825
- GeneID:   1452334
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1430
- NMPDR:   fig|243232.1.peg.1471
- TIGR:   MJ1430
- HOGENOM:   HBG294308
- OMA:   MHYYSTS
- ProtClustDB:   PRK00051
- BioCyc:   MJAN243232:MJ_1430-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14926; Mature: 14926

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVEDTVKKLNLKFRNIEGERLILAITCDENKNVLMVAFMNEEALKKTLETGYMHYYSTS
CCHHHHHHHHCEEEECCCCCEEEEEEEECCCCCEEEEEEECHHHHHHHHHHCCEEEEECH
RKKLWRKGEESGNVQKLIKFYRDCDGDALLFIVEQKGVACHEGYYSCFHYKIEDGELKIT
HHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCEECCCCEEEEEEEEECCEEEEE
GEYYSKR
ECCCCCC
>Mature Secondary Structure
MDVEDTVKKLNLKFRNIEGERLILAITCDENKNVLMVAFMNEEALKKTLETGYMHYYSTS
CCHHHHHHHHCEEEECCCCCEEEEEEEECCCCCEEEEEEECHHHHHHHHHHCCEEEEECH
RKKLWRKGEESGNVQKLIKFYRDCDGDALLFIVEQKGVACHEGYYSCFHYKIEDGELKIT
HHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCEECCCCEEEEEEEEECCEEEEE
GEYYSKR
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087