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The map label for this gene is bioA [H]

Identifier: 15669490

GI number: 15669490

Start: 1247256

End: 1248650

Strand: Direct

Name: bioA [H]

Synonym: MJ1300

Alternate gene names: 15669490

Gene position: 1247256-1248650 (Clockwise)

Preceding gene: 15669489

Following gene: 15669501

Centisome position: 74.91

GC content: 34.91

Gene sequence:

>1395_bases
GTGAATAAAATGAACATTGATAAAAATTTACTTGAAAAATGGGATAAAGAATATATTTGGCATCCATACACACAGATGAA
AGAATATAGAGAATCAAAAAACTTGATTATTGAGAGAGGAGAGGGCAATTATTTAATTGACATTTATGGAAATAAGTATT
TGGATGCTGTTTCATCTATATGGTGTAATCTATTTGGACATAGTAGAAAGGAGATAATTGAAGCAATAAAAAATCAAGCT
GATAAAATCTGCCATTCAACACTTTTAGGCTGTGGAAACGTCCCATCAATTTTATTGGCAAAAAAATTGGTGGATATAAC
TCCAAAGCATTTAACAAAGGTATTTTACTCTGAAGATGGAGCAGAGGCAGTTGAAATAGCAATTAAAATGGCTTATCAAT
ATTATGTTTTAAGAGGAGATAAGGGAAGAACTAAATTTATTTCAGTTAAAGAAGGCTATCATGGGGACACTGTTGGAGCA
ATGAGTGTTGGGGGGAGTGAATTATTCCATGGGGTTTTTAAGCCTTTATTGTTTAAAGGCTATCATGCAAATCCTCCTTA
CTGCTACAGATGCAAATACCACAACTTTAAAGATACTGATGAGAGAAATGAAAAAGGTTGTGAAATGGAATGTTTAAATG
AGATGATTAGTTTAATTGAAAAACATGCTGAGGAAGTATTTTGTGTTATCCTTGAAGGAGGAATTATGGGTTCTGCTGGA
ATGATTCCATATCCAGATGGATATATTGAAGGAGTTGCAAAGGCATGTAAGGAGAATGATGTAATCTTTATCCTCGATGA
GGTAGCTACTGGATTTGGAAGAACTGGGAAGATGTTTTTCTGTGATAATGAAGAGCTAAAAAAGTTGGAGAAGCCAGATA
TCCTTTGTCTTGGAAAGGGATTAACTGGAGGCTATTTGCCATTAGCGGCAACTCTAACAACTGATGAAATCTATAACCAA
TTCTTAGGAGAGTTTGGAGAGAGTAAGCAACTCTATCATGGTCATACATACACTGGAAACCAACTTCTATGCTCTGCTGC
ATTAGCAACATTAGAGATTTTTGAGAAGGAGAATGTGATAGAGAATATCCAACCAAAAATAAAGCTCTTCCATAAAGAAT
TAAGGAAATTAAAGGAACTTGAGCATGTTGGAGATGTTAGAGGAAGGGGTTTTATGGTCGGAATAGAGCTTGTAAAAGAT
AAAGAGACTAAAGAACCCTACCCTTACGGTTATAAAGCTGGCTACAGAGTTGCTGAAAAGCTGTTAGAAAAAGGTATCTA
CATGAGACCAATTGGTAATGTTATTATCTTAGTCCCACCATTGTCAATAACTGAGAAAGAGATTATTTATCTATGCGATG
CGTTGTATGAAGCTATAAAGGAAGCTGACCTGTAA

Upstream 100 bases:

>100_bases
AAAAAACCTTTGAAACAATAGAAAAAGTTGGGAACATTGAAATAATTGGGATTGTTAAAAGTAGGGAAGATTTTGAGATT
GATTTTGAAAAGATTTTGAG

Downstream 100 bases:

>100_bases
TAATGGACATTAATTAGGGCTGAAAGCCCTAACTTATAACCAATTATCAAAGCTAAATTATCTAATTAAGGAATATTTAG
AAGCCCAAAGGGCTTCTATA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNKMNIDKNLLEKWDKEYIWHPYTQMKEYRESKNLIIERGEGNYLIDIYGNKYLDAVSSIWCNLFGHSRKEIIEAIKNQA
DKICHSTLLGCGNVPSILLAKKLVDITPKHLTKVFYSEDGAEAVEIAIKMAYQYYVLRGDKGRTKFISVKEGYHGDTVGA
MSVGGSELFHGVFKPLLFKGYHANPPYCYRCKYHNFKDTDERNEKGCEMECLNEMISLIEKHAEEVFCVILEGGIMGSAG
MIPYPDGYIEGVAKACKENDVIFILDEVATGFGRTGKMFFCDNEELKKLEKPDILCLGKGLTGGYLPLAATLTTDEIYNQ
FLGEFGESKQLYHGHTYTGNQLLCSAALATLEIFEKENVIENIQPKIKLFHKELRKLKELEHVGDVRGRGFMVGIELVKD
KETKEPYPYGYKAGYRVAEKLLEKGIYMRPIGNVIILVPPLSITEKEIIYLCDALYEAIKEADL

Sequences:

>Translated_464_residues
MNKMNIDKNLLEKWDKEYIWHPYTQMKEYRESKNLIIERGEGNYLIDIYGNKYLDAVSSIWCNLFGHSRKEIIEAIKNQA
DKICHSTLLGCGNVPSILLAKKLVDITPKHLTKVFYSEDGAEAVEIAIKMAYQYYVLRGDKGRTKFISVKEGYHGDTVGA
MSVGGSELFHGVFKPLLFKGYHANPPYCYRCKYHNFKDTDERNEKGCEMECLNEMISLIEKHAEEVFCVILEGGIMGSAG
MIPYPDGYIEGVAKACKENDVIFILDEVATGFGRTGKMFFCDNEELKKLEKPDILCLGKGLTGGYLPLAATLTTDEIYNQ
FLGEFGESKQLYHGHTYTGNQLLCSAALATLEIFEKENVIENIQPKIKLFHKELRKLKELEHVGDVRGRGFMVGIELVKD
KETKEPYPYGYKAGYRVAEKLLEKGIYMRPIGNVIILVPPLSITEKEIIYLCDALYEAIKEADL
>Mature_464_residues
MNKMNIDKNLLEKWDKEYIWHPYTQMKEYRESKNLIIERGEGNYLIDIYGNKYLDAVSSIWCNLFGHSRKEIIEAIKNQA
DKICHSTLLGCGNVPSILLAKKLVDITPKHLTKVFYSEDGAEAVEIAIKMAYQYYVLRGDKGRTKFISVKEGYHGDTVGA
MSVGGSELFHGVFKPLLFKGYHANPPYCYRCKYHNFKDTDERNEKGCEMECLNEMISLIEKHAEEVFCVILEGGIMGSAG
MIPYPDGYIEGVAKACKENDVIFILDEVATGFGRTGKMFFCDNEELKKLEKPDILCLGKGLTGGYLPLAATLTTDEIYNQ
FLGEFGESKQLYHGHTYTGNQLLCSAALATLEIFEKENVIENIQPKIKLFHKELRKLKELEHVGDVRGRGFMVGIELVKD
KETKEPYPYGYKAGYRVAEKLLEKGIYMRPIGNVIILVPPLSITEKEIIYLCDALYEAIKEADL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=30.5288461538462, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI13994255, Length=452, Percent_Identity=27.4336283185841, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=26.8965517241379, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=26.4367816091954, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=26.9521410579345, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI284507298, Length=332, Percent_Identity=30.1204819277108, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI24119277, Length=441, Percent_Identity=24.0362811791383, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI188536080, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI38679950, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI38679946, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786991, Length=448, Percent_Identity=33.9285714285714, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI145693181, Length=431, Percent_Identity=30.1624129930394, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1788044, Length=431, Percent_Identity=28.7703016241299, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789759, Length=364, Percent_Identity=27.7472527472527, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1787560, Length=435, Percent_Identity=26.8965517241379, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1789016, Length=457, Percent_Identity=24.72647702407, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=454, Percent_Identity=30.8370044052863, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144271, Length=438, Percent_Identity=26.2557077625571, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=27.313769751693, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=230, Percent_Identity=32.6086956521739, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=391, Percent_Identity=24.0409207161125, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=478, Percent_Identity=29.4979079497908, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=445, Percent_Identity=27.6404494382022, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323470, Length=458, Percent_Identity=26.6375545851528, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321456, Length=320, Percent_Identity=25.3125, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574759, Length=453, Percent_Identity=29.5805739514349, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=29.2035398230088, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21357415, Length=429, Percent_Identity=27.2727272727273, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=28.2051282051282, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281366494, Length=395, Percent_Identity=24.0506329113924, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24667139, Length=395, Percent_Identity=24.0506329113924, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24667143, Length=395, Percent_Identity=24.0506329113924, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 52689; Mature: 52689

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKMNIDKNLLEKWDKEYIWHPYTQMKEYRESKNLIIERGEGNYLIDIYGNKYLDAVSSI
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHHHHH
WCNLFGHSRKEIIEAIKNQADKICHSTLLGCGNVPSILLAKKLVDITPKHLTKVFYSEDG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCC
AEAVEIAIKMAYQYYVLRGDKGRTKFISVKEGYHGDTVGAMSVGGSELFHGVFKPLLFKG
HHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHCC
YHANPPYCYRCKYHNFKDTDERNEKGCEMECLNEMISLIEKHAEEVFCVILEGGIMGSAG
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCEECCCC
MIPYPDGYIEGVAKACKENDVIFILDEVATGFGRTGKMFFCDNEELKKLEKPDILCLGKG
CCCCCCHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCEEEECCHHHHHCCCCCEEEEECC
LTGGYLPLAATLTTDEIYNQFLGEFGESKQLYHGHTYTGNQLLCSAALATLEIFEKENVI
CCCCCCCEEEEECHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ENIQPKIKLFHKELRKLKELEHVGDVRGRGFMVGIELVKDKETKEPYPYGYKAGYRVAEK
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
LLEKGIYMRPIGNVIILVPPLSITEKEIIYLCDALYEAIKEADL
HHHCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKMNIDKNLLEKWDKEYIWHPYTQMKEYRESKNLIIERGEGNYLIDIYGNKYLDAVSSI
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHHHHH
WCNLFGHSRKEIIEAIKNQADKICHSTLLGCGNVPSILLAKKLVDITPKHLTKVFYSEDG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCC
AEAVEIAIKMAYQYYVLRGDKGRTKFISVKEGYHGDTVGAMSVGGSELFHGVFKPLLFKG
HHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHCC
YHANPPYCYRCKYHNFKDTDERNEKGCEMECLNEMISLIEKHAEEVFCVILEGGIMGSAG
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCEECCCC
MIPYPDGYIEGVAKACKENDVIFILDEVATGFGRTGKMFFCDNEELKKLEKPDILCLGKG
CCCCCCHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCEEEECCHHHHHCCCCCEEEEECC
LTGGYLPLAATLTTDEIYNQFLGEFGESKQLYHGHTYTGNQLLCSAALATLEIFEKENVI
CCCCCCCEEEEECHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ENIQPKIKLFHKELRKLKELEHVGDVRGRGFMVGIELVKDKETKEPYPYGYKAGYRVAEK
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHH
LLEKGIYMRPIGNVIILVPPLSITEKEIIYLCDALYEAIKEADL
HHHCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]