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The map label for this gene is purL

Identifier: 15669450

GI number: 15669450

Start: 1207641

End: 1209842

Strand: Reverse

Name: purL

Synonym: MJ1264

Alternate gene names: 15669450

Gene position: 1209842-1207641 (Counterclockwise)

Preceding gene: 15669451

Following gene: 15669439

Centisome position: 72.66

GC content: 35.38

Gene sequence:

>2202_bases
ATGGATGAGAATGATTTAAAGTATATAGAAAAAGTTTTAGGAAGAAAGCCAAACCACATAGAGTTAGCAATGTTTGAAAA
CTTATGGAGTGAGCACTGTGCTTATAGAACCTCAAAAAAGCTCTTAAGAATGTTTGCTAAAACAGTTAATGAAAAGACCT
CTAAAAATATAGTTGTTGGAATTGGAGATGATGCCGCTGTAATTAGATTGAAAAATGATATCTGCTTAGCAATAGCTATG
GAAAGCCATAACCACCCATCATACATAGACCCATATAATGGAGCTGCTACAGGAGTTGGTGGGATTGTTAGAGATGTTTT
GTCAATGGGAGCTAAGCCAATAGCTTTATTAGACCCATTAAGGTTTGGAGATATATTTGGAAAGGAAGGGGATAAAGTTA
GATGGCTAATTGAAGGAGTTGTTAAAGGTATTGGAGATTATGGAAATAGGATTGGAGTCCCAACAGTTGGAGGAGAGTGT
GAGTTTGATAGCTCTTTTGATTACAACAACTTAGTAAATGTTGTTTGTGTCGGCTTAGTTAAGGAGAATGAAATCATTAC
AGGTAAAGCTAAAGAGCCAGGATTGTCTTTAATATTAATCGGCTCAACAGGAAGGGATGGAATAGGAGGAGCTTCATTTG
CATCAAAGGATTTAACTGAGGAAAGTGAGGAAGAAAGGCCAAGTGTTCAGGTTGGGGATGCATTTTCTGAAAAATGTTTA
ATTGATGCTGTTTTAGAGGCAGTAAAAACAGGAAAAGTTAAAGCTATGAAGGATTTAGGGGCTGCGGGGCTTTCAGGAGC
TTCATCTGAGATGTGTTATGGTGGAGGAGTAGGATGTGAGCTTTACTTAGAAAATGTTGTATTGAGAGAGCCATTAACTC
CTTACGAAATTATGGTTTCTGAGAGTCAGGAGAGGATGTTATTAGCTGTTGAACCAGGAAGTGAGGAGGAAATAATTGAA
ATATTTAAAAAGTATGAACTACCTGCATCAGTTATTGGAAAAACAATTCCAGAGAAGAGGATTATTGCCAAATACAAAGG
AGAAGTTGTTGTTGATTTACCATTAGATTTGTTATGTGAAGCTCCTTTATATGATAGGGAAGGTAAAGAGGACTTAAAAG
AAAAAGAGGATGATAAGGAAAAAATAAAGATGCCAGAAGATTTAAATGCTGTGTTATTAAAACTCTTAGAGAGTCCAAAT
ATTTGCTCAAAGGAATGGATTTATCAGCAGTATGACCACGAAGTTCAAATAAGAACTGTTGTAAAGCCAGGAAAAGATGC
CGCTGTTTTAAGAATAAATGAAGTTTATCCAATGGGAATTGCCTTAACAACTGACTGTAACTCAAGATACTGCAAACTAA
ACCCTTATGTAGGGGCAGTAAATGCTGTAGCTGAAGCTGTGAGAAATTTAGCAACAGTTGGAGCTGAACCAATAGCTATG
CTTGATAATCTAAACTTTGGAAATCCTGAAAGACCAGAGAGATTTTGGCAGTTGGCAGAATGCATTAAAGGTTTAGCAGA
TGCCGCTGAATTCTTTGAAATCCCAGTTGTTGGAGGAAACGTAAGTTTATACAATGAAACAGTTATTGAAGGTAAAGAAC
ATCCAATAAACCCAACTCCCGCAATATTTGTATTAGGTAAAGTTGAGGATGTTGAAAAAGTTCCGGGAGTTTTAGATAAC
AAGATTAAGGAAGGAGATATATTAATAATTACAAATGAAACAAAAGATGAAATGGGAGGAAGCGAATATTATAAAGTTAT
ACACAATACTGAAGAGGGAAGAGTGCCAAGAGTTGATTTAGAGAAAGAGAAGAAGATTTATGAAGAAGTTAGGGAAGTTG
TAAAAGAAGGATTGGTTAGTGAGGCAGTAGATTGCTCAAGAGGAGGTTTAGCTGTAGCTTTAGCCAAAATGGCTGTATTA
AACAATATTGGTTTAGAAGTTGATTTAACTGAGTATAATAAAAATAATTTAAGGGACGATATTTTACTGTTCTCAGAAAC
TTCTGGAAGGATAATATTGGCAGTTAGAGATGAAAATAAAGATAAAGTTTTAAGTAAATTAAGTTCTGCTTATATAATTG
GAAAAGTTGGAGGAAGCAGATTGAAAATAAAGATTAACGAAAAGGATGTTGTTAATTTGGATGTGGAAGAGATGAAAAAG
AGGTATTATGAAGCATTTCCAAAGATGATGGGAGAGCTTTAG

Upstream 100 bases:

>100_bases
GAGGATGAGATATTTGATAAATAAGCATAAAGGTTTAATAACACATCCTTCATTTTTTGTATATCCACAAATAATATTAA
TTAACTAATAAGGTGTAATT

Downstream 100 bases:

>100_bases
ATTAAATATTCTTATTTTTTTAGTTTATCTAACTTTACTACCTGCTTTTATATCCTTATCAACAGTTAATAAGCTAACAT
TTCCTTCATCATCTTCGGCT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MDENDLKYIEKVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFAKTVNEKTSKNIVVGIGDDAAVIRLKNDICLAIAM
ESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPLRFGDIFGKEGDKVRWLIEGVVKGIGDYGNRIGVPTVGGEC
EFDSSFDYNNLVNVVCVGLVKENEIITGKAKEPGLSLILIGSTGRDGIGGASFASKDLTEESEEERPSVQVGDAFSEKCL
IDAVLEAVKTGKVKAMKDLGAAGLSGASSEMCYGGGVGCELYLENVVLREPLTPYEIMVSESQERMLLAVEPGSEEEIIE
IFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCEAPLYDREGKEDLKEKEDDKEKIKMPEDLNAVLLKLLESPN
ICSKEWIYQQYDHEVQIRTVVKPGKDAAVLRINEVYPMGIALTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAM
LDNLNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNVSLYNETVIEGKEHPINPTPAIFVLGKVEDVEKVPGVLDN
KIKEGDILIITNETKDEMGGSEYYKVIHNTEEGRVPRVDLEKEKKIYEEVREVVKEGLVSEAVDCSRGGLAVALAKMAVL
NNIGLEVDLTEYNKNNLRDDILLFSETSGRIILAVRDENKDKVLSKLSSAYIIGKVGGSRLKIKINEKDVVNLDVEEMKK
RYYEAFPKMMGEL

Sequences:

>Translated_733_residues
MDENDLKYIEKVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFAKTVNEKTSKNIVVGIGDDAAVIRLKNDICLAIAM
ESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPLRFGDIFGKEGDKVRWLIEGVVKGIGDYGNRIGVPTVGGEC
EFDSSFDYNNLVNVVCVGLVKENEIITGKAKEPGLSLILIGSTGRDGIGGASFASKDLTEESEEERPSVQVGDAFSEKCL
IDAVLEAVKTGKVKAMKDLGAAGLSGASSEMCYGGGVGCELYLENVVLREPLTPYEIMVSESQERMLLAVEPGSEEEIIE
IFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCEAPLYDREGKEDLKEKEDDKEKIKMPEDLNAVLLKLLESPN
ICSKEWIYQQYDHEVQIRTVVKPGKDAAVLRINEVYPMGIALTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAM
LDNLNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNVSLYNETVIEGKEHPINPTPAIFVLGKVEDVEKVPGVLDN
KIKEGDILIITNETKDEMGGSEYYKVIHNTEEGRVPRVDLEKEKKIYEEVREVVKEGLVSEAVDCSRGGLAVALAKMAVL
NNIGLEVDLTEYNKNNLRDDILLFSETSGRIILAVRDENKDKVLSKLSSAYIIGKVGGSRLKIKINEKDVVNLDVEEMKK
RYYEAFPKMMGEL
>Mature_733_residues
MDENDLKYIEKVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFAKTVNEKTSKNIVVGIGDDAAVIRLKNDICLAIAM
ESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPLRFGDIFGKEGDKVRWLIEGVVKGIGDYGNRIGVPTVGGEC
EFDSSFDYNNLVNVVCVGLVKENEIITGKAKEPGLSLILIGSTGRDGIGGASFASKDLTEESEEERPSVQVGDAFSEKCL
IDAVLEAVKTGKVKAMKDLGAAGLSGASSEMCYGGGVGCELYLENVVLREPLTPYEIMVSESQERMLLAVEPGSEEEIIE
IFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCEAPLYDREGKEDLKEKEDDKEKIKMPEDLNAVLLKLLESPN
ICSKEWIYQQYDHEVQIRTVVKPGKDAAVLRINEVYPMGIALTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAM
LDNLNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNVSLYNETVIEGKEHPINPTPAIFVLGKVEDVEKVPGVLDN
KIKEGDILIITNETKDEMGGSEYYKVIHNTEEGRVPRVDLEKEKKIYEEVREVVKEGLVSEAVDCSRGGLAVALAKMAVL
NNIGLEVDLTEYNKNNLRDDILLFSETSGRIILAVRDENKDKVLSKLSSAYIIGKVGGSRLKIKINEKDVVNLDVEEMKK
RYYEAFPKMMGEL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=837, Percent_Identity=24.3727598566308, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553022, Length=855, Percent_Identity=22.9239766081871, Blast_Score=96, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=748, Percent_Identity=23.2620320855615, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24582111, Length=856, Percent_Identity=23.714953271028, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24582109, Length=856, Percent_Identity=23.714953271028, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137292, Length=856, Percent_Identity=23.714953271028, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_METJA (Q58660)

Other databases:

- EMBL:   L77117
- PIR:   G64457
- RefSeq:   NP_248260.1
- ProteinModelPortal:   Q58660
- SMR:   Q58660
- GeneID:   1452162
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1264
- NMPDR:   fig|243232.1.peg.1297
- TIGR:   MJ1264
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   MJAN243232:MJ_1264-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80867; Mature: 80867

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDENDLKYIEKVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFAKTVNEKTSKNIVVG
CCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
IGDDAAVIRLKNDICLAIAMESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPL
ECCCEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCC
RFGDIFGKEGDKVRWLIEGVVKGIGDYGNRIGVPTVGGECEFDSSFDYNNLVNVVCVGLV
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEE
KENEIITGKAKEPGLSLILIGSTGRDGIGGASFASKDLTEESEEERPSVQVGDAFSEKCL
ECCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCCHHHCCCCEEECCHHHHHHH
IDAVLEAVKTGKVKAMKDLGAAGLSGASSEMCYGGGVGCELYLENVVLREPLTPYEIMVS
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEC
ESQERMLLAVEPGSEEEIIEIFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCE
CCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCEEEECCHHHHCC
APLYDREGKEDLKEKEDDKEKIKMPEDLNAVLLKLLESPNICSKEWIYQQYDHEVQIRTV
CCCCCCCCHHHHHHCCCCHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEE
VKPGKDAAVLRINEVYPMGIALTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAM
ECCCCCEEEEEEECCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHH
LDNLNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNVSLYNETVIEGKEHPINPTP
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEECHHEECCCCCCCCCCC
AIFVLGKVEDVEKVPGVLDNKIKEGDILIITNETKDEMGGSEYYKVIHNTEEGRVPRVDL
EEEEEECHHHHHHCCCHHHCCCCCCCEEEEECCCHHHCCCHHHHHHEECCCCCCCCCCCC
EKEKKIYEEVREVVKEGLVSEAVDCSRGGLAVALAKMAVLNNIGLEVDLTEYNKNNLRDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
ILLFSETSGRIILAVRDENKDKVLSKLSSAYIIGKVGGSRLKIKINEKDVVNLDVEEMKK
EEEEECCCCEEEEEEECCCHHHHHHHHHCEEEEEECCCCEEEEEECCCCEEECCHHHHHH
RYYEAFPKMMGEL
HHHHHHHHHHCCC
>Mature Secondary Structure
MDENDLKYIEKVLGRKPNHIELAMFENLWSEHCAYRTSKKLLRMFAKTVNEKTSKNIVVG
CCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
IGDDAAVIRLKNDICLAIAMESHNHPSYIDPYNGAATGVGGIVRDVLSMGAKPIALLDPL
ECCCEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCC
RFGDIFGKEGDKVRWLIEGVVKGIGDYGNRIGVPTVGGECEFDSSFDYNNLVNVVCVGLV
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEE
KENEIITGKAKEPGLSLILIGSTGRDGIGGASFASKDLTEESEEERPSVQVGDAFSEKCL
ECCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCHHCCCCCHHHCCCCEEECCHHHHHHH
IDAVLEAVKTGKVKAMKDLGAAGLSGASSEMCYGGGVGCELYLENVVLREPLTPYEIMVS
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEC
ESQERMLLAVEPGSEEEIIEIFKKYELPASVIGKTIPEKRIIAKYKGEVVVDLPLDLLCE
CCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCEEEECCHHHHCC
APLYDREGKEDLKEKEDDKEKIKMPEDLNAVLLKLLESPNICSKEWIYQQYDHEVQIRTV
CCCCCCCCHHHHHHCCCCHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEE
VKPGKDAAVLRINEVYPMGIALTTDCNSRYCKLNPYVGAVNAVAEAVRNLATVGAEPIAM
ECCCCCEEEEEEECCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHH
LDNLNFGNPERPERFWQLAECIKGLADAAEFFEIPVVGGNVSLYNETVIEGKEHPINPTP
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEECHHEECCCCCCCCCCC
AIFVLGKVEDVEKVPGVLDNKIKEGDILIITNETKDEMGGSEYYKVIHNTEEGRVPRVDL
EEEEEECHHHHHHCCCHHHCCCCCCCEEEEECCCHHHCCCHHHHHHEECCCCCCCCCCCC
EKEKKIYEEVREVVKEGLVSEAVDCSRGGLAVALAKMAVLNNIGLEVDLTEYNKNNLRDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
ILLFSETSGRIILAVRDENKDKVLSKLSSAYIIGKVGGSRLKIKINEKDVVNLDVEEMKK
EEEEECCCCEEEEEEECCCHHHHHHHHHCEEEEEECCCCEEEEEECCCCEEECCHHHHHH
RYYEAFPKMMGEL
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087