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The map label for this gene is guaB [C]

Identifier: 15669417

GI number: 15669417

Start: 1175441

End: 1176331

Strand: Reverse

Name: guaB [C]

Synonym: MJ1232

Alternate gene names: 15669417

Gene position: 1176331-1175441 (Counterclockwise)

Preceding gene: 15669419

Following gene: 15669416

Centisome position: 70.65

GC content: 31.76

Gene sequence:

>891_bases
ATGGAACTAACGGTTGTGCAGAGAGAGATATTACAAGAACTTATAAACCTATATAGAGAAAAAAATAGACCAATCAAAGG
AACAGAAATTGCCTTAAGATTAAATAGGAATCCAGGAACTATAAGAAACCAAATGCAAGCTTTAAGGGCATTAGATTTAG
TTGATGGTGTTCCTGGACCTAAAGGGGGATATGTGCCAACAAGTAAAGCTTATAGAGCTTTGGGATTAGAAGATGAGGGG
GAGATAATAGTCCCTATATATAAAGATGGAAAGAAAGTTGAGGGAGTTAAGGTTGTAAAAATAGAGTTTGACACTGTTTC
ACATGAAAAATGCTGTTCTTCAAAGATACACATTGAGGGGGATACAAAGCACTTTAACATTGGAGATATTATTAGAGTCG
GCCCTACTTATCATAATAAAATTATTATTAATGGAAAAATTATTGGAAGGGATGATATTCATAGGATTTTGCTAATAGAT
GTTTTAGGAGTTTCAAGTATCCCAAATATAAAAGTTGGAGATGTGGGGATTAAAGAGGTTTGGACAATAAATCCAAATTG
CACTTTAAGAGAAACTGCCAAATTATTTGCTGAAAAATATATCAGTGGAGCTCCAGTTGTTGATAACGATAAATTGGTTG
GTGTAATAAGCCTACATGATATTGCTGAGAATATAGATAATATTGATAAAAAGGTCAAAGAGGTTATGAGAAGAGACGTT
ATAACAATACATAAAGATGAAAAGATATATGATGCATTAAAAATTATGAACAAAAATAATGTGGGGAGATTGGTTATAGT
CGATGATAACAATAAAATCGTTGGAATTATAACAAGAACAGATATATTAAAGATTATTAGTGGTAAATTTCCAGAGAATT
TCCATACTTAA

Upstream 100 bases:

>100_bases
CGATAAGTATATATTTATTTTATTGCCATAAATATTTATCATGGATGTCAATAATCTATTATAATTTATAATCATTAGTA
TTTTTAATAAGGGGGTTTTT

Downstream 100 bases:

>100_bases
TAGAACCTAAGTAAAGCATATATATCATTTCAATCAATACTACACTACGGCTATAAACAAGGATAGAGATTTTTGTATTA
ATTAATTTAAACTCAATTTT

Product: hypothetical protein

Products: H+; Nicotinamide adenine dinucleotide - reduced; Xanthosine 5'-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MELTVVQREILQELINLYREKNRPIKGTEIALRLNRNPGTIRNQMQALRALDLVDGVPGPKGGYVPTSKAYRALGLEDEG
EIIVPIYKDGKKVEGVKVVKIEFDTVSHEKCCSSKIHIEGDTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLID
VLGVSSIPNIKVGDVGIKEVWTINPNCTLRETAKLFAEKYISGAPVVDNDKLVGVISLHDIAENIDNIDKKVKEVMRRDV
ITIHKDEKIYDALKIMNKNNVGRLVIVDDNNKIVGIITRTDILKIISGKFPENFHT

Sequences:

>Translated_296_residues
MELTVVQREILQELINLYREKNRPIKGTEIALRLNRNPGTIRNQMQALRALDLVDGVPGPKGGYVPTSKAYRALGLEDEG
EIIVPIYKDGKKVEGVKVVKIEFDTVSHEKCCSSKIHIEGDTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLID
VLGVSSIPNIKVGDVGIKEVWTINPNCTLRETAKLFAEKYISGAPVVDNDKLVGVISLHDIAENIDNIDKKVKEVMRRDV
ITIHKDEKIYDALKIMNKNNVGRLVIVDDNNKIVGIITRTDILKIISGKFPENFHT
>Mature_296_residues
MELTVVQREILQELINLYREKNRPIKGTEIALRLNRNPGTIRNQMQALRALDLVDGVPGPKGGYVPTSKAYRALGLEDEG
EIIVPIYKDGKKVEGVKVVKIEFDTVSHEKCCSSKIHIEGDTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLID
VLGVSSIPNIKVGDVGIKEVWTINPNCTLRETAKLFAEKYISGAPVVDNDKLVGVISLHDIAENIDNIDKKVKEVMRRDV
ITIHKDEKIYDALKIMNKNNVGRLVIVDDNNKIVGIITRTDILKIISGKFPENFHT

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG2524

COG function: function code K; Predicted transcriptional regulator, contains C-terminal CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): Y1232_METJA (Q58629)

Other databases:

- EMBL:   L77117
- PIR:   G64453
- RefSeq:   NP_248227.1
- ProteinModelPortal:   Q58629
- GeneID:   1452128
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1232
- NMPDR:   fig|243232.1.peg.1264
- TIGR:   MJ1232
- HOGENOM:   HBG297719
- OMA:   VQKEILQ
- ProtClustDB:   CLSK876501
- BioCyc:   MJAN243232:MJ_1232-MONOMER
- GO:   GO:0016020
- InterPro:   IPR013785
- InterPro:   IPR001807
- InterPro:   IPR000644
- InterPro:   IPR016436
- InterPro:   IPR005104
- InterPro:   IPR011991
- Gene3D:   G3DSA:3.20.20.70
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR11689
- PIRSF:   PIRSF005063
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF03444 DUF293

EC number: 1.1.1.205 [C]

Molecular weight: Translated: 33205; Mature: 33205

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTVVQREILQELINLYREKNRPIKGTEIALRLNRNPGTIRNQMQALRALDLVDGVPGP
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
KGGYVPTSKAYRALGLEDEGEIIVPIYKDGKKVEGVKVVKIEFDTVSHEKCCSSKIHIEG
CCCCCCCHHHHHCCCCCCCCCEEEEEECCCCEECCEEEEEEEECCCCCHHHCCCCEEEEC
DTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLIDVLGVSSIPNIKVGDVGIKEV
CCCEECCCCEEEECCCCCCEEEEEEEEECCHHHHEEEEEEECCCCCCCCEEECCCCCEEE
WTINPNCTLRETAKLFAEKYISGAPVVDNDKLVGVISLHDIAENIDNIDKKVKEVMRRDV
EEECCCCCHHHHHHHHHHHHCCCCCEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCC
ITIHKDEKIYDALKIMNKNNVGRLVIVDDNNKIVGIITRTDILKIISGKFPENFHT
EEEECCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MELTVVQREILQELINLYREKNRPIKGTEIALRLNRNPGTIRNQMQALRALDLVDGVPGP
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
KGGYVPTSKAYRALGLEDEGEIIVPIYKDGKKVEGVKVVKIEFDTVSHEKCCSSKIHIEG
CCCCCCCHHHHHCCCCCCCCCEEEEEECCCCEECCEEEEEEEECCCCCHHHCCCCEEEEC
DTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLIDVLGVSSIPNIKVGDVGIKEV
CCCEECCCCEEEECCCCCCEEEEEEEEECCHHHHEEEEEEECCCCCCCCEEECCCCCEEE
WTINPNCTLRETAKLFAEKYISGAPVVDNDKLVGVISLHDIAENIDNIDKKVKEVMRRDV
EEECCCCCHHHHHHHHHHHHCCCCCEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCC
ITIHKDEKIYDALKIMNKNNVGRLVIVDDNNKIVGIITRTDILKIISGKFPENFHT
EEEECCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; IMP; Nicotinamide adenine dinucleotide [C]

Specific reaction: H2O + IMP + Nicotinamide adenine dinucleotide --> H+ + Nicotinamide adenine dinucleotide - reduced + Xanthosine 5'-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087