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The map label for this gene is aroC

Identifier: 15669364

GI number: 15669364

Start: 1113783

End: 1114919

Strand: Reverse

Name: aroC

Synonym: MJ1175

Alternate gene names: 15669364

Gene position: 1114919-1113783 (Counterclockwise)

Preceding gene: 15669365

Following gene: 15669363

Centisome position: 66.96

GC content: 35.62

Gene sequence:

>1137_bases
TTGGTGACATTAATGAACACCTATGGGGATATGTTTAGAGTTACAGTTTTTGGAGAAAGTCATGGAAAGGCTGTTGGAGC
AGTTGTTGATGGATGTCCAGCTAATCTGCCTTTATCTGAAGAGGATATCCAAAAAGAGCTTGACAGGAGAAGACCAGGGC
AGAGCATCTTCTCAACACCAAGAAAAGAAGAGGATAAAGTTGAAATCTTATCAGGAATTTTTGAGGGGAAAACTACTGGA
GCTCCTATTTGCTCAATAGTCTATAACAAAAACATGAGACCTAAAGATTACTCAAAAATTAAAGATACACCAAGACCTGG
ACATGCAGATTTAACCTATAGATTGAAGTATAAAAACTATGATTATAGGGGAGGAGGAAGGGCAAGTGGTAGAGTAACGA
TAGGGCATGTTATTGGAGGAGCTATTGCTAAAAAGCTTCTATCTTACACATACAACATAAAAATTATTGGTTATACCATA
AAGATTGGAAAGATTGAAGGAGATTTCAGCTACTATAAAAATCCAGAGGTTTTTGAAAATGAAAAATCCTTAGAGAGATT
AATAGAGATTATTGAAAGTAATCCATTGAGATGTCCATCAATGAATGAGAAAGAGATGGAGGAGTATGTTTTAAAGGCAA
TGGAAAATAAAGATAGTGTTGGAGGAGTTGTTGAAATTGTTGCATTAAATGTTCCTGTTGGAGTTGGAAATCCAATATTC
AATAAGTTAAATGGAGAATTGGCAAGAGCTTTAATGAGTATAAATGCTGTTAAAGGAGTTGAGATAGGGGCTGGTTTTAA
AGCGGCTGAGATGTATGGAAGTGAGATGAACGATGAGATGTATTTTGATGACGACAAAAATATAAGATTCAAAACAAACA
ACTGCGGTGGCATATTGGGAGGAATTAGCTGTGGAACTCCAATAGTTTTAAGAATTGCAGTAAAGCCAACACCTTCAATA
GGTAAAAAGCAAAAAACCATAAATTTAAAAACCTTAGAAAATGTTGAAATTGAAATTGAAGGAAGACACGACCCAGTTAT
AGTTCCAAGGATTGTTCCAGTGGCTGAAGCAATGGTTGCTATAACCTTAGCTGATTTGATGATTAAGGGAGGATTTATTC
ATCCGTGTAGCTTATAA

Upstream 100 bases:

>100_bases
AGGAACCAGCACACTTGGATGTTCTCTACAGATAAACCTTTTTTATTTTTTGACTATTTTAATTTTTATTTTAAATGTAA
AACTAAGCAATTAAAAATTT

Downstream 100 bases:

>100_bases
AATTTTTATATTTTTTATTTTATTATCTATATTATTATTATTTTGTTTTTATTTATCTTAATTTGGTTTATTTAAAAGAA
ATGGGTGAAAATAATGAAGT

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MVTLMNTYGDMFRVTVFGESHGKAVGAVVDGCPANLPLSEEDIQKELDRRRPGQSIFSTPRKEEDKVEILSGIFEGKTTG
APICSIVYNKNMRPKDYSKIKDTPRPGHADLTYRLKYKNYDYRGGGRASGRVTIGHVIGGAIAKKLLSYTYNIKIIGYTI
KIGKIEGDFSYYKNPEVFENEKSLERLIEIIESNPLRCPSMNEKEMEEYVLKAMENKDSVGGVVEIVALNVPVGVGNPIF
NKLNGELARALMSINAVKGVEIGAGFKAAEMYGSEMNDEMYFDDDKNIRFKTNNCGGILGGISCGTPIVLRIAVKPTPSI
GKKQKTINLKTLENVEIEIEGRHDPVIVPRIVPVAEAMVAITLADLMIKGGFIHPCSL

Sequences:

>Translated_378_residues
MVTLMNTYGDMFRVTVFGESHGKAVGAVVDGCPANLPLSEEDIQKELDRRRPGQSIFSTPRKEEDKVEILSGIFEGKTTG
APICSIVYNKNMRPKDYSKIKDTPRPGHADLTYRLKYKNYDYRGGGRASGRVTIGHVIGGAIAKKLLSYTYNIKIIGYTI
KIGKIEGDFSYYKNPEVFENEKSLERLIEIIESNPLRCPSMNEKEMEEYVLKAMENKDSVGGVVEIVALNVPVGVGNPIF
NKLNGELARALMSINAVKGVEIGAGFKAAEMYGSEMNDEMYFDDDKNIRFKTNNCGGILGGISCGTPIVLRIAVKPTPSI
GKKQKTINLKTLENVEIEIEGRHDPVIVPRIVPVAEAMVAITLADLMIKGGFIHPCSL
>Mature_378_residues
MVTLMNTYGDMFRVTVFGESHGKAVGAVVDGCPANLPLSEEDIQKELDRRRPGQSIFSTPRKEEDKVEILSGIFEGKTTG
APICSIVYNKNMRPKDYSKIKDTPRPGHADLTYRLKYKNYDYRGGGRASGRVTIGHVIGGAIAKKLLSYTYNIKIIGYTI
KIGKIEGDFSYYKNPEVFENEKSLERLIEIIESNPLRCPSMNEKEMEEYVLKAMENKDSVGGVVEIVALNVPVGVGNPIF
NKLNGELARALMSINAVKGVEIGAGFKAAEMYGSEMNDEMYFDDDKNIRFKTNNCGGILGGISCGTPIVLRIAVKPTPSI
GKKQKTINLKTLENVEIEIEGRHDPVIVPRIVPVAEAMVAITLADLMIKGGFIHPCSL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=365, Percent_Identity=46.8493150684932, Blast_Score=301, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6321290, Length=371, Percent_Identity=45.822102425876, Blast_Score=317, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_METJA (Q58575)

Other databases:

- EMBL:   L77117
- PIR:   F64446
- RefSeq:   NP_248169.1
- ProteinModelPortal:   Q58575
- SMR:   Q58575
- GeneID:   1452073
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1175
- NMPDR:   fig|243232.1.peg.1206
- TIGR:   MJ1175
- HOGENOM:   HBG292336
- OMA:   TATIGKE
- ProtClustDB:   PRK05382
- BioCyc:   MJAN243232:MJ_1175-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_A
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 41616; Mature: 41616

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLMNTYGDMFRVTVFGESHGKAVGAVVDGCPANLPLSEEDIQKELDRRRPGQSIFSTP
CEEEEECCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHCCC
RKEEDKVEILSGIFEGKTTGAPICSIVYNKNMRPKDYSKIKDTPRPGHADLTYRLKYKNY
CCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEECCC
DYRGGGRASGRVTIGHVIGGAIAKKLLSYTYNIKIIGYTIKIGKIEGDFSYYKNPEVFEN
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHEEEEEEEEEEEEEEEEECCCCCCCCCCHHCC
EKSLERLIEIIESNPLRCPSMNEKEMEEYVLKAMENKDSVGGVVEIVALNVPVGVGNPIF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCHHH
NKLNGELARALMSINAVKGVEIGAGFKAAEMYGSEMNDEMYFDDDKNIRFKTNNCGGILG
HHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCCCCCEEECCCCCEEEEECCCCCEEC
GISCGTPIVLRIAVKPTPSIGKKQKTINLKTLENVEIEIEGRHDPVIVPRIVPVAEAMVA
CCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECEEEEEECCCCCEEECCHHHHHHHHHH
ITLADLMIKGGFIHPCSL
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVTLMNTYGDMFRVTVFGESHGKAVGAVVDGCPANLPLSEEDIQKELDRRRPGQSIFSTP
CEEEEECCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHCCC
RKEEDKVEILSGIFEGKTTGAPICSIVYNKNMRPKDYSKIKDTPRPGHADLTYRLKYKNY
CCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCCCCEEEEEEECCC
DYRGGGRASGRVTIGHVIGGAIAKKLLSYTYNIKIIGYTIKIGKIEGDFSYYKNPEVFEN
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHEEEEEEEEEEEEEEEEECCCCCCCCCCHHCC
EKSLERLIEIIESNPLRCPSMNEKEMEEYVLKAMENKDSVGGVVEIVALNVPVGVGNPIF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCHHH
NKLNGELARALMSINAVKGVEIGAGFKAAEMYGSEMNDEMYFDDDKNIRFKTNNCGGILG
HHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCCCCCEEECCCCCEEEEECCCCCEEC
GISCGTPIVLRIAVKPTPSIGKKQKTINLKTLENVEIEIEGRHDPVIVPRIVPVAEAMVA
CCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECEEEEEECCCCCEEECCHHHHHHHHHH
ITLADLMIKGGFIHPCSL
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087