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The map label for this gene is coaBC

Identifier: 15669103

GI number: 15669103

Start: 844578

End: 845789

Strand: Reverse

Name: coaBC

Synonym: MJ0913

Alternate gene names: 15669103

Gene position: 845789-844578 (Counterclockwise)

Preceding gene: 15669104

Following gene: 15669101

Centisome position: 50.8

GC content: 29.37

Gene sequence:

>1212_bases
ATGATAAGTGAAATCATGCACCCAACTAAATTATTAAAAGGAACTAAATCAAAGCTCTTAGAGAATAAAAAAATCTTAGT
TGCTGTAACTTCATCAATAGCGGCTATTGAAACACCAAAGTTAATGAGAGAATTGATAAGGCATGGAGCAGAGGTTTATT
GCATCATTACAGAAGAGACAAAGAAGATTATAGGCAAAGAGGCATTAAAATTTGGTTGTGGAAATGAGGTTTATGAAGAG
ATAACTGGAGATATTGAGCATATCCTTTTATACAATGAATGTGATTGCCTTTTAATATATCCAGCAACAGCCAATATAAT
CTCAAAAATAAATTTAGGAATTGCAGATAATATTGTAAATACAACTGCCTTAATGTTTTTTGGAAATAAACCGATATTTA
TTGTCCCAGCAATGCATGAAAATATGTTCAATGCAATTAAAAGACATATAGATAAGCTTAAAGAGAAAGATAAAATTTAT
ATCATATCTCCAAAGTTTGAAGAAGGGAAGGCAAAAGTAGCAAATATTGAGGATGTTGTTAAAGCAGTTATTGAAAAAAT
CGGAAATAACTTAAAAAAAGAAGGAAATAGAGTTTTAATATTAAACGGAGGGACTGTTGAGTTTATAGACAAAGTTAGAG
TTATATCTAATTTATCATCTGGAAAAATGGGTGTTGCTTTAGCTGAAGCTTTTTGCAAAGAAGGATTTTATGTTGAGGTT
ATAACCGCTATGGGTTTAGAGCCACCTTATTATATAAAAAATCATAAGGTTTTAACAGCTAAGGAGATGTTAAATAAAGC
TATTGAGTTGGCTAAGGACTTTGATATAATTATTTCATCGGCAGCAATATCTGATTTTACTGTTGAGAGTTTTGAAGGTA
AGCTAAGTTCTGAAGAAGAGCTAATATTAAAGTTAAAGAGAAATCCTAAAGTTTTAGAAGAGTTAAGAAGGATTTATAAG
GATAAGGTAATTATTGGATTTAAAGCAGAATACAATTTAGATGAAAAGGAACTTATAAATAGGGCTAAGGAGCGACTAAA
TAAATACAATTTAAATATGATTATAGCCAATGATTTAAGTAAGCACTATTTTGGAGATGATTATATCGAGGTTTATATTA
TAACAAAATATGAAGTTGAGAAAATCTCTGGATCTAAAAAGGAAATTTCCGAAAGAATTGTTGAAAAAGTTAAAAAATTG
GTGAAATCATGA

Upstream 100 bases:

>100_bases
GACTTATATATTGCATGCACCGCAATAATCAAAAATTATCCATTATGGACTAAAAACAAAAAACATTTTGAGAGATTAAA
AGAATTTGGTTTAAAAATAT

Downstream 100 bases:

>100_bases
GCAAAAGAGAAGAAACTGGATTAGCAACAAGTGCTGGGCTAATAAGATACATGGATGAGACATTTTCAAAAATTAGAGTT
AAGCCAGAACATGTAATTGG

Product: pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MISEIMHPTKLLKGTKSKLLENKKILVAVTSSIAAIETPKLMRELIRHGAEVYCIITEETKKIIGKEALKFGCGNEVYEE
ITGDIEHILLYNECDCLLIYPATANIISKINLGIADNIVNTTALMFFGNKPIFIVPAMHENMFNAIKRHIDKLKEKDKIY
IISPKFEEGKAKVANIEDVVKAVIEKIGNNLKKEGNRVLILNGGTVEFIDKVRVISNLSSGKMGVALAEAFCKEGFYVEV
ITAMGLEPPYYIKNHKVLTAKEMLNKAIELAKDFDIIISSAAISDFTVESFEGKLSSEEELILKLKRNPKVLEELRRIYK
DKVIIGFKAEYNLDEKELINRAKERLNKYNLNMIIANDLSKHYFGDDYIEVYIITKYEVEKISGSKKEISERIVEKVKKL
VKS

Sequences:

>Translated_403_residues
MISEIMHPTKLLKGTKSKLLENKKILVAVTSSIAAIETPKLMRELIRHGAEVYCIITEETKKIIGKEALKFGCGNEVYEE
ITGDIEHILLYNECDCLLIYPATANIISKINLGIADNIVNTTALMFFGNKPIFIVPAMHENMFNAIKRHIDKLKEKDKIY
IISPKFEEGKAKVANIEDVVKAVIEKIGNNLKKEGNRVLILNGGTVEFIDKVRVISNLSSGKMGVALAEAFCKEGFYVEV
ITAMGLEPPYYIKNHKVLTAKEMLNKAIELAKDFDIIISSAAISDFTVESFEGKLSSEEELILKLKRNPKVLEELRRIYK
DKVIIGFKAEYNLDEKELINRAKERLNKYNLNMIIANDLSKHYFGDDYIEVYIITKYEVEKISGSKKEISERIVEKVKKL
VKS
>Mature_403_residues
MISEIMHPTKLLKGTKSKLLENKKILVAVTSSIAAIETPKLMRELIRHGAEVYCIITEETKKIIGKEALKFGCGNEVYEE
ITGDIEHILLYNECDCLLIYPATANIISKINLGIADNIVNTTALMFFGNKPIFIVPAMHENMFNAIKRHIDKLKEKDKIY
IISPKFEEGKAKVANIEDVVKAVIEKIGNNLKKEGNRVLILNGGTVEFIDKVRVISNLSSGKMGVALAEAFCKEGFYVEV
ITAMGLEPPYYIKNHKVLTAKEMLNKAIELAKDFDIIISSAAISDFTVESFEGKLSSEEELILKLKRNPKVLEELRRIYK
DKVIIGFKAEYNLDEKELINRAKERLNKYNLNMIIANDLSKHYFGDDYIEVYIITKYEVEKISGSKKEISERIVEKVKKL
VKS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family

Homologues:

Organism=Escherichia coli, GI87082301, Length=367, Percent_Identity=28.8828337874659, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COABC_METJA (Q58323)

Other databases:

- EMBL:   L77117
- PIR:   A64414
- RefSeq:   NP_247908.1
- ProteinModelPortal:   Q58323
- GeneID:   1451802
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0913
- NMPDR:   fig|243232.1.peg.945
- TIGR:   MJ0913
- HOGENOM:   HBG523890
- OMA:   VTSGPTH
- ProtClustDB:   CLSK876384
- BioCyc:   MJAN243232:MJ_0913-MONOMER
- BRENDA:   4.1.1.36
- BRENDA:   6.3.2.5
- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382
- Gene3D:   G3DSA:3.40.50.10300
- Gene3D:   G3DSA:3.40.50.1950
- TIGRFAMs:   TIGR00521

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein; SSF102645 DNA/pantothenate-metab_flavo_C; SSF52507 Flavoprotein

EC number: =4.1.1.36; =6.3.2.5

Molecular weight: Translated: 45671; Mature: 45671

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEIMHPTKLLKGTKSKLLENKKILVAVTSSIAAIETPKLMRELIRHGAEVYCIITEET
CCCHHHCHHHHHHCHHHHHHCCCEEEEEEECCHHHCCCHHHHHHHHHCCCEEEEEEEHHH
KKIIGKEALKFGCGNEVYEEITGDIEHILLYNECDCLLIYPATANIISKINLGIADNIVN
HHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHHCCCHHHHHHH
TTALMFFGNKPIFIVPAMHENMFNAIKRHIDKLKEKDKIYIISPKFEEGKAKVANIEDVV
HEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHH
KAVIEKIGNNLKKEGNRVLILNGGTVEFIDKVRVISNLSSGKMGVALAEAFCKEGFYVEV
HHHHHHHCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEE
ITAMGLEPPYYIKNHKVLTAKEMLNKAIELAKDFDIIISSAAISDFTVESFEGKLSSEEE
HHHCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHEEHHHHCCCCHHHHCCCCCCCHH
LILKLKRNPKVLEELRRIYKDKVIIGFKAEYNLDEKELINRAKERLNKYNLNMIIANDLS
HHEEECCCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCH
KHYFGDDYIEVYIITKYEVEKISGSKKEISERIVEKVKKLVKS
HHCCCCCEEEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISEIMHPTKLLKGTKSKLLENKKILVAVTSSIAAIETPKLMRELIRHGAEVYCIITEET
CCCHHHCHHHHHHCHHHHHHCCCEEEEEEECCHHHCCCHHHHHHHHHCCCEEEEEEEHHH
KKIIGKEALKFGCGNEVYEEITGDIEHILLYNECDCLLIYPATANIISKINLGIADNIVN
HHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHHCCCHHHHHHH
TTALMFFGNKPIFIVPAMHENMFNAIKRHIDKLKEKDKIYIISPKFEEGKAKVANIEDVV
HEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHH
KAVIEKIGNNLKKEGNRVLILNGGTVEFIDKVRVISNLSSGKMGVALAEAFCKEGFYVEV
HHHHHHHCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEE
ITAMGLEPPYYIKNHKVLTAKEMLNKAIELAKDFDIIISSAAISDFTVESFEGKLSSEEE
HHHCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHEEHHHHCCCCHHHHCCCCCCCHH
LILKLKRNPKVLEELRRIYKDKVIIGFKAEYNLDEKELINRAKERLNKYNLNMIIANDLS
HHEEECCCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCH
KHYFGDDYIEVYIITKYEVEKISGSKKEISERIVEKVKKLVKS
HHCCCCCEEEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087