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The map label for this gene is argH

Identifier: 15668974

GI number: 15668974

Start: 713720

End: 715174

Strand: Reverse

Name: argH

Synonym: MJ0791

Alternate gene names: 15668974

Gene position: 715174-713720 (Counterclockwise)

Preceding gene: 15668992

Following gene: 15668964

Centisome position: 42.95

GC content: 32.37

Gene sequence:

>1455_bases
ATGAACATCTTAAGGAGAGGAAGATTAGGAAATTCAATAAAAGAAGATGTAGCAAAATACACAACAAGCTTAAGCTTTGA
TAAGGAGATTTTTGAAGCGGATATCTTATGCGACATAGCTCACGTAATAATGCTCTATGAACAAGGTATAATAAAAAAGG
AAGACGCAAAAAAGATTATTGAAGGGTTAAAAGAGATTTATAAAAAAGGAATGGAAAATCTCAACTTAGACCCTTCCTTG
GATGATATACACATGGTCATTGAAAGTGAGCTAATTAAAAAACTTGGTGAAGATGTAGCAGGAAGAATGCACACTGGAAG
AAGTAGAAATGATGAAGTAGCAACAGATTTAAGAATTGCATTAAGAGAGAAGGTCTTAATAATAGCTAAATCTTTAATTA
AGATGTTAAAAGATATTTTAGAATTAGCTGAGAAACATAAAGAGACATTAATCGTTGGATATACACATTTACAGCATGCT
CAGCCAGTAACTTTTGCTCATCATTTGCTTAGCTACGTTTCAGCAATTGAAAGAGATATTTTAAGATTGTTAGATGCTTA
CAAAAGAATAAATATTTCTCCATTAGGTTGTGGAGCAATGGCAACAACTGGATTTAAGATAAACAGGGAGAGAACTAAAG
AATTATTGGGCTTTGATGCTTTGATAGAGAATTCAATGGATGGTGTTTCAGCAAGGGACTTTATATTAGAGACAATGGCT
GACTTAGCAATATTAGGAACAAACTTATCAAAAATCTGTGAAGAATTGATTTTATTCTCAACCTATGAATTTGGAACTAT
TGAGATTGCTAATGAGTTCTGCTCAACATCTTCAATAATGCCTCAAAAGAAAAACCCTGATGTGGCGGAGATAGCGAGAG
CTAAGCTATCCAAATTAAATGGAAATTTGGTTACTGCATTAACAATATTAAAAGCTCTACCAAATACTTATAATAGAGAT
TTACAGGAAATAAGCCCACATTTATGGGATAGCGTTTATACAACAATAGACACAATAAAAATGGTTCATGGAATGCTAAA
AACAATAAAAATTAATAAAGAGAGAATGGAAGAATTAGCTAAAGCAAACTACTCAACTGCAACAGAATTGGCAGATACTT
TGGTTAGAGAGACAGGAATTCCATTTAGAACAGCACATGGCATTGTTGGAGAAGTTGTTAGAAGAAGTATAGAAGAAAAA
AAGGATATGATTGAAGTTATCTATGAAGTTTTAGAAAAATACAATTTGAAAGTTGATGAGGAGAAGATAAAAAAGGCATT
AGACCCTTATGAGAATGTTAAGATGAGAGATGTTATAGGGGGCCCTGCTCCAGAAGAAGTTGAAAAAAGGATAAAGGTAT
TTAGGGAGAGATTAGACAGATATGAAAAAGAGGTTGATGAGAAATTGCAGAAGATAAATAAAGTTAAGGAGATACTTTTA
TCCTATGAAATTTAA

Upstream 100 bases:

>100_bases
AAAGTAAATTATTTTTAACTATTTTATAATTTTATATCAAAAAATGAAATATAACATAATCAATATTATTTAAACACGAT
TAAAATGCATTGGTGAAATA

Downstream 100 bases:

>100_bases
TTTATTTTTATTTGCATTTTATCAAAGTAATGATAAAATCATATATTTCCAAACATAAACTGCCATTAAAGCCCATATTG
CCACTAAAATATACCCTTCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNILRRGRLGNSIKEDVAKYTTSLSFDKEIFEADILCDIAHVIMLYEQGIIKKEDAKKIIEGLKEIYKKGMENLNLDPSL
DDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRIALREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHA
QPVTFAHHLLSYVSAIERDILRLLDAYKRINISPLGCGAMATTGFKINRERTKELLGFDALIENSMDGVSARDFILETMA
DLAILGTNLSKICEELILFSTYEFGTIEIANEFCSTSSIMPQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRD
LQEISPHLWDSVYTTIDTIKMVHGMLKTIKINKERMEELAKANYSTATELADTLVRETGIPFRTAHGIVGEVVRRSIEEK
KDMIEVIYEVLEKYNLKVDEEKIKKALDPYENVKMRDVIGGPAPEEVEKRIKVFRERLDRYEKEVDEKLQKINKVKEILL
SYEI

Sequences:

>Translated_484_residues
MNILRRGRLGNSIKEDVAKYTTSLSFDKEIFEADILCDIAHVIMLYEQGIIKKEDAKKIIEGLKEIYKKGMENLNLDPSL
DDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRIALREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHA
QPVTFAHHLLSYVSAIERDILRLLDAYKRINISPLGCGAMATTGFKINRERTKELLGFDALIENSMDGVSARDFILETMA
DLAILGTNLSKICEELILFSTYEFGTIEIANEFCSTSSIMPQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRD
LQEISPHLWDSVYTTIDTIKMVHGMLKTIKINKERMEELAKANYSTATELADTLVRETGIPFRTAHGIVGEVVRRSIEEK
KDMIEVIYEVLEKYNLKVDEEKIKKALDPYENVKMRDVIGGPAPEEVEKRIKVFRERLDRYEKEVDEKLQKINKVKEILL
SYEI
>Mature_484_residues
MNILRRGRLGNSIKEDVAKYTTSLSFDKEIFEADILCDIAHVIMLYEQGIIKKEDAKKIIEGLKEIYKKGMENLNLDPSL
DDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRIALREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHA
QPVTFAHHLLSYVSAIERDILRLLDAYKRINISPLGCGAMATTGFKINRERTKELLGFDALIENSMDGVSARDFILETMA
DLAILGTNLSKICEELILFSTYEFGTIEIANEFCSTSSIMPQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRD
LQEISPHLWDSVYTTIDTIKMVHGMLKTIKINKERMEELAKANYSTATELADTLVRETGIPFRTAHGIVGEVVRRSIEEK
KDMIEVIYEVLEKYNLKVDEEKIKKALDPYENVKMRDVIGGPAPEEVEKRIKVFRERLDRYEKEVDEKLQKINKVKEILL
SYEI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=456, Percent_Identity=33.3333333333333, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI68303542, Length=456, Percent_Identity=33.3333333333333, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI68303547, Length=460, Percent_Identity=31.304347826087, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI68303549, Length=456, Percent_Identity=30.4824561403509, Blast_Score=228, Evalue=8e-60,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=37.636761487965, Blast_Score=319, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321806, Length=464, Percent_Identity=36.4224137931034, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=33.4811529933481, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=33.4811529933481, Blast_Score=254, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_METJA (Q58201)

Other databases:

- EMBL:   L77117
- PIR:   G64398
- RefSeq:   NP_247778.1
- ProteinModelPortal:   Q58201
- SMR:   Q58201
- GeneID:   1451670
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0791
- NMPDR:   fig|243232.1.peg.815
- TIGR:   MJ0791
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   MJAN243232:MJ_0791-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 55165; Mature: 55165

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILRRGRLGNSIKEDVAKYTTSLSFDKEIFEADILCDIAHVIMLYEQGIIKKEDAKKII
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EGLKEIYKKGMENLNLDPSLDDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRIA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHAQPVTFAHHLLSYVSAIERDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHH
LRLLDAYKRINISPLGCGAMATTGFKINRERTKELLGFDALIENSMDGVSARDFILETMA
HHHHHHHHHCCCCCCCCCHHHHCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DLAILGTNLSKICEELILFSTYEFGTIEIANEFCSTSSIMPQKKNPDVAEIARAKLSKLN
HHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
GNLVTALTILKALPNTYNRDLQEISPHLWDSVYTTIDTIKMVHGMLKTIKINKERMEELA
CCHHHHHHHHHHCCCHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KANYSTATELADTLVRETGIPFRTAHGIVGEVVRRSIEEKKDMIEVIYEVLEKYNLKVDE
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EKIKKALDPYENVKMRDVIGGPAPEEVEKRIKVFRERLDRYEKEVDEKLQKINKVKEILL
HHHHHHHCHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYEI
HCCC
>Mature Secondary Structure
MNILRRGRLGNSIKEDVAKYTTSLSFDKEIFEADILCDIAHVIMLYEQGIIKKEDAKKII
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EGLKEIYKKGMENLNLDPSLDDIHMVIESELIKKLGEDVAGRMHTGRSRNDEVATDLRIA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHAQPVTFAHHLLSYVSAIERDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHH
LRLLDAYKRINISPLGCGAMATTGFKINRERTKELLGFDALIENSMDGVSARDFILETMA
HHHHHHHHHCCCCCCCCCHHHHCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DLAILGTNLSKICEELILFSTYEFGTIEIANEFCSTSSIMPQKKNPDVAEIARAKLSKLN
HHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
GNLVTALTILKALPNTYNRDLQEISPHLWDSVYTTIDTIKMVHGMLKTIKINKERMEELA
CCHHHHHHHHHHCCCHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KANYSTATELADTLVRETGIPFRTAHGIVGEVVRRSIEEKKDMIEVIYEVLEKYNLKVDE
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EKIKKALDPYENVKMRDVIGGPAPEEVEKRIKVFRERLDRYEKEVDEKLQKINKVKEILL
HHHHHHHCHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYEI
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087