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The map label for this gene is 15668884

Identifier: 15668884

GI number: 15668884

Start: 629858

End: 630538

Strand: Direct

Name: 15668884

Synonym: MJ0703

Alternate gene names: NA

Gene position: 629858-630538 (Clockwise)

Preceding gene: 15668883

Following gene: 15668885

Centisome position: 37.83

GC content: 30.4

Gene sequence:

>681_bases
ATGAAAATAATCCCAGTCATTGATTTAAAAGACAAAATAGCTGTGCATGGAAAGAGTGGAAATAGAGATGAATATAAGCC
ATTAGAGTCAGTTATCTGCAAATCATCAAATCCTATTGAAGTAGCAAAAGCCTACAAAGAAAGAGGAGCTAAAACTATCT
ATATTGCTGACTTAAACTTTATAATGGGCAATGGAGATAATTTTGATATTATAAAAGAGATAGATTTTATAAACAAGATT
GTTGATATTGGAGTAAAGAGTAGAGAGGATTTAGAAACTATCAAAAAAGTTTTAAATAAAGATGATAGGGCAATTGTAGC
AACAGAGACATTAAAAGATATTGAATTGCTTAAAGAAAAAGATATAGTTGTTAGCTTAGATTTTAAGAATGGGAATCTTT
TAAACTACAGCTTGGATGAGATTTTATCTTGTGTTAGAGATGATACACCACTAATAATCTTAGATATCTCTTCAGTTGGA
ACTCAAAGAGGGGTTAATGCAGAGCTTATAAAATATGTTTTAGATAAAACTAACAATCCGGTGTATGTTGGTGGTGGAAT
TAAAGGAATGGAAGATTTAGAGCTATGCTATAACTTAGGAGTTGATGCTGTTTTAATAGCAACGGCAATACATAAAGGGG
TTTTAGATTTAGAGGAGATTATTAATAAGTTTGGTGATTAA

Upstream 100 bases:

>100_bases
AATAAACATGGCTAAGGTTGGGGAGAAGGGGCATTATTTAGAATGGGATAGGGGAGTTTTAGAGGTTAGATATTAATAAA
TAATAATTTAGAGGGAAACT

Downstream 100 bases:

>100_bases
TAAAGTTCTATCAGTTGATGAATTCAATCTAATGAAAAAATAAACACTACTTTTTACAGAAACATATTTAAAAGATGGTG
TTATAGTTGGATGAAGTTGA

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA2

Products: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-; $phosphoribosyl)imidazole-4-carboxamide

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNFIMGNGDNFDIIKEIDFINKI
VDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLKEKDIVVSLDFKNGNLLNYSLDEILSCVRDDTPLIILDISSVG
TQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVLDLEEIINKFGD

Sequences:

>Translated_226_residues
MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNFIMGNGDNFDIIKEIDFINKI
VDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLKEKDIVVSLDFKNGNLLNYSLDEILSCVRDDTPLIILDISSVG
TQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVLDLEEIINKFGD
>Mature_226_residues
MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNFIMGNGDNFDIIKEIDFINKI
VDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLKEKDIVVSLDFKNGNLLNYSLDEILSCVRDDTPLIILDISSVG
TQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVLDLEEIINKFGD

Specific function: Unknown

COG id: COG1411

COG function: function code R; Uncharacterized protein related to proFAR isomerase (HisA)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y703_METJA (Q58114)

Other databases:

- EMBL:   L77117
- PIR:   G64387
- RefSeq:   NP_247687.1
- ProteinModelPortal:   Q58114
- GeneID:   1451570
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0703
- NMPDR:   fig|243232.1.peg.724
- TIGR:   MJ0703
- HOGENOM:   HBG541613
- OMA:   KVYIADL
- ProtClustDB:   CLSK876298
- BioCyc:   MJAN243232:MJ_0703-MONOMER
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR004650
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00734

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: 5.3.1.16

Molecular weight: Translated: 25067; Mature: 25067

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNF
CCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEEE
IMGNGDNFDIIKEIDFINKIVDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLKEK
EECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCC
DIVVSLDFKNGNLLNYSLDEILSCVRDDTPLIILDISSVGTQRGVNAELIKYVLDKTNNP
CEEEEEECCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCC
VYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVLDLEEIINKFGD
EEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNF
CCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEEE
IMGNGDNFDIIKEIDFINKIVDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLKEK
EECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCC
DIVVSLDFKNGNLLNYSLDEILSCVRDDTPLIILDISSVGTQRGVNAELIKYVLDKTNNP
CEEEEEECCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCC
VYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVLDLEEIINKFGD
EEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 1-(5-phosphoribosyl)-5-[(5-; $phosphoribosylamino)methylideneamino]imidazole-4-carboxamide

Specific reaction: 1-(5-phosphoribosyl)-5-[(5- $phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5- $[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5- $phosphoribosyl)imidazole-4-carboxamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087