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The map label for this gene is trpD

Identifier: 15668409

GI number: 15668409

Start: 225108

End: 226118

Strand: Direct

Name: trpD

Synonym: MJ0234

Alternate gene names: 15668409

Gene position: 225108-226118 (Clockwise)

Preceding gene: 15668408

Following gene: 15668410

Centisome position: 13.52

GC content: 35.81

Gene sequence:

>1011_bases
ATGATAACTGAGGCATTAAAAAAGGTTATTGAATTTAAGGATTTAGATGAAAAAGAGGCAGAGGCTGTTATGAAAGACAT
CATGAGTGGAAATGCAAAACCTACACAAATAGCTGCTATCTTAACAGCTTTAAGAATGAAAGGAGAAACTATAGAAGAAA
TAACTGCCTTTGCAAAGATTATGAGAGAATTTTCACTAAAAATAAATCCTAATGTTCCTAAGCTTTTAGATACTTGCGGA
ACTGGAGGAGATAATTTAAACACATTCAATATAAGCACTGCCACAGCCTTTGTAGTCTCTGCCTATGTTCCAGTTGCAAA
GCATGGAAATAAAGCAGTGAGCAGTAAAAGTGGAAGTGCTGACGTCTTAGAGGCATTAGGAGTTAATCTAAATGTTCCTA
TTGAGAGGGTTAAAGAATCTATAGAGAAAATTGGCATTGGGTTTTTGTTTGCCCCTCACTTTCACCCAGCGATGAAGTTC
GCTACACCAGTTAGGAAGGAGTTGGGGATAAGGACTGTTTTTAATGTATTAGGACCTTTAACAAATCCAGCTAACGCTAA
TTATCAACTAATGGGAGTTTATGATGAAAAATTGACGGAGAAATTGGCAAATGTTTTAAAGAATTTGGGATTGAAGGGGG
CTTTAGTAGTACATGGTAGTGGAATGGACGAAATCACTACTATAGGAAAAACAAAAATATCTGAGTTAAGAAATGGGGAG
ATAAAAAGCTATTACATTGAACCAGAGGATTTTGGCATTAAAAAAGCTAAGTTAGAAGATATTAGAGGGGGAGATGCTGA
AGAAAATGCCAAGATAATTGGGGAGATATTTGAAGGTGAGGAGGTTGGAGCTAAGAGGGATATTGTTGTCTTAAATGCTG
CCTTTGCCCTATATATTGCTGAAGAGGCTAAAGATGTTGAAGAGGGTATTAAATTAGCTGAAAAATCCATTGATGAAGGT
AAAGCGTTAAAAAAATTAGAGGATTTAATTGAATTCTATAGAGAGGGTTAA

Upstream 100 bases:

>100_bases
AGGGAATATCTTACGCATTATCAACATTTGTTGATTTCTATTTAGGTGTGTTTTCAATAAGGGCAGTTGCATTATACTAT
AAAGATAGAAAGGGGATAAC

Downstream 100 bases:

>100_bases
GTATGGAAAAATTAATAATAAACTCAATGAAAAAGGTATTTTTAGAAGAGCTGAAAGATCTTGAGAATGAATTAAATCAA
ATTTTTAAAAAATATAATGT

Product: anthranilate synthase component II TrpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MITEALKKVIEFKDLDEKEAEAVMKDIMSGNAKPTQIAAILTALRMKGETIEEITAFAKIMREFSLKINPNVPKLLDTCG
TGGDNLNTFNISTATAFVVSAYVPVAKHGNKAVSSKSGSADVLEALGVNLNVPIERVKESIEKIGIGFLFAPHFHPAMKF
ATPVRKELGIRTVFNVLGPLTNPANANYQLMGVYDEKLTEKLANVLKNLGLKGALVVHGSGMDEITTIGKTKISELRNGE
IKSYYIEPEDFGIKKAKLEDIRGGDAEENAKIIGEIFEGEEVGAKRDIVVLNAAFALYIAEEAKDVEEGIKLAEKSIDEG
KALKKLEDLIEFYREG

Sequences:

>Translated_336_residues
MITEALKKVIEFKDLDEKEAEAVMKDIMSGNAKPTQIAAILTALRMKGETIEEITAFAKIMREFSLKINPNVPKLLDTCG
TGGDNLNTFNISTATAFVVSAYVPVAKHGNKAVSSKSGSADVLEALGVNLNVPIERVKESIEKIGIGFLFAPHFHPAMKF
ATPVRKELGIRTVFNVLGPLTNPANANYQLMGVYDEKLTEKLANVLKNLGLKGALVVHGSGMDEITTIGKTKISELRNGE
IKSYYIEPEDFGIKKAKLEDIRGGDAEENAKIIGEIFEGEEVGAKRDIVVLNAAFALYIAEEAKDVEEGIKLAEKSIDEG
KALKKLEDLIEFYREG
>Mature_336_residues
MITEALKKVIEFKDLDEKEAEAVMKDIMSGNAKPTQIAAILTALRMKGETIEEITAFAKIMREFSLKINPNVPKLLDTCG
TGGDNLNTFNISTATAFVVSAYVPVAKHGNKAVSSKSGSADVLEALGVNLNVPIERVKESIEKIGIGFLFAPHFHPAMKF
ATPVRKELGIRTVFNVLGPLTNPANANYQLMGVYDEKLTEKLANVLKNLGLKGALVVHGSGMDEITTIGKTKISELRNGE
IKSYYIEPEDFGIKKAKLEDIRGGDAEENAKIIGEIFEGEEVGAKRDIVVLNAAFALYIAEEAKDVEEGIKLAEKSIDEG
KALKKLEDLIEFYREG

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=276, Percent_Identity=41.304347826087, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320561, Length=337, Percent_Identity=34.4213649851632, Blast_Score=155, Evalue=1e-38,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_METJA (Q57686)

Other databases:

- EMBL:   L77117
- PIR:   C64329
- RefSeq:   NP_247205.1
- ProteinModelPortal:   Q57686
- SMR:   Q57686
- GeneID:   1451087
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0234
- NMPDR:   fig|243232.1.peg.242
- TIGR:   MJ0234
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- ProtClustDB:   CLSK2517560
- BioCyc:   MJAN243232:MJ_0234-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36631; Mature: 36631

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEALKKVIEFKDLDEKEAEAVMKDIMSGNAKPTQIAAILTALRMKGETIEEITAFAKI
CCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
MREFSLKINPNVPKLLDTCGTGGDNLNTFNISTATAFVVSAYVPVAKHGNKAVSSKSGSA
HHHHCCCCCCCCHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHCCCCCCH
DVLEALGVNLNVPIERVKESIEKIGIGFLFAPHFHPAMKFATPVRKELGIRTVFNVLGPL
HHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TNPANANYQLMGVYDEKLTEKLANVLKNLGLKGALVVHGSGMDEITTIGKTKISELRNGE
CCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
IKSYYIEPEDFGIKKAKLEDIRGGDAEENAKIIGEIFEGEEVGAKRDIVVLNAAFALYIA
CEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHH
EEAKDVEEGIKLAEKSIDEGKALKKLEDLIEFYREG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITEALKKVIEFKDLDEKEAEAVMKDIMSGNAKPTQIAAILTALRMKGETIEEITAFAKI
CCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
MREFSLKINPNVPKLLDTCGTGGDNLNTFNISTATAFVVSAYVPVAKHGNKAVSSKSGSA
HHHHCCCCCCCCHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHCCCCCCH
DVLEALGVNLNVPIERVKESIEKIGIGFLFAPHFHPAMKFATPVRKELGIRTVFNVLGPL
HHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TNPANANYQLMGVYDEKLTEKLANVLKNLGLKGALVVHGSGMDEITTIGKTKISELRNGE
CCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
IKSYYIEPEDFGIKKAKLEDIRGGDAEENAKIIGEIFEGEEVGAKRDIVVLNAAFALYIA
CEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHH
EEAKDVEEGIKLAEKSIDEGKALKKLEDLIEFYREG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087