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The map label for this gene is atpB

Identifier: 15668389

GI number: 15668389

Start: 205740

End: 207137

Strand: Reverse

Name: atpB

Synonym: MJ0216

Alternate gene names: 15668389

Gene position: 207137-205740 (Counterclockwise)

Preceding gene: 15668390

Following gene: 15668388

Centisome position: 12.44

GC content: 39.84

Gene sequence:

>1398_bases
ATGGCTACAGCAGCATCAGCAATTGAATACTCATCAGTTAAGAGTATTGCAGGACCTTTGTTAATCGTTGAGGGAGTTGA
AGGAGCAGCTTATGGAGAGATTGTTGAGGTTATCTGTCCAGATGGAGAGAAGAGAATGGGACAGGTTTTGGAGGCAAGAG
AGGGTTTAGCAGTTGTTCAGGTATTTGAGGGAACAACAGGATTAAGCACAAAAGATACAAGAGTAAGATTCACAGGAAGA
ACTGCTAAGATTGGAGTTTCAATGGAAATGTTAGGAAGAATATTCAACGGAGCAGGGAAACCAATTGATGGAGGACCAGA
AATAGTTCCTGAGAAAGAGTTAGATATTAATGGTTATCCATTAAACCCTGTTTCAAGAAAAGTTCCAAGTGATTTCATCC
AAACAGGTATTTCAACAATTGATGGAATGAATACATTAGTTAGAGGGCAGAAACTGCCAATCTTCTCAGGTTCTGGTTTG
CCACACAACCAGTTAGCTGCACAGATTGCAAGACAGGCAAAGGTTAGAGGAGAAGGAGAGAAATTCGCAGTTGTCTTTGC
AGCAATGGGTATTACATCAGAAGAGGCAAACTTCTTCATGGAAGAGTTTAGAAAGACAGGAGCTTTAGAGAGAGCAGTTG
TCTTCATAAACTTAGCTGACGACCCTGCAATTGAGAGAATTTTAACACCAAGAATTGCTTTAACTGTTGCTGAATACTTA
GCTTATGAGAAGGATATGCACGTTCTTGTTATCCTAACAGATATGACAAACTACTGTGAGGCGTTAAGAGAAATCTCAGC
AGCAAGAAACGAGGTTCCGGGAAGAAGAGGTTACCCAGGTTACATGTATACTGACTTGGCTACAATCTATGAAAGAGCTG
GTAGAGTTAAAGGTAGAACAGGAACAATAACTCAAATTCCAATCTTGACAATGCCAGATGATGATATAACTCACCCAATT
CCTGACTTAACTGGTTATATTACAGAGGGGCAGATTGTCTTATCAAGAGAGTTGCACAGAAAAGGTATCTACCCACCAGT
TGATGTTCTTCCATCATTATCAAGATTGGCTGGAAACGGACAGGGTCCAGGAAAAACAAGAGAAGACCATAAAAAAGTTG
TTAACCAGGCTTATGCTGCCTATGCAGAGGGTAGAAGTTTAAGAGATTTAGTTGCTGTTGTTGGGGAAGAGGCATTGACA
GATAGGGATAGGGCATACTTGAAGTTTGCAGATGAGTTTGAAGATAAGTTTGTTAGACAAGGAAAGGATGAGGATAGAAG
TATAGAGGAAACTCTTGACTTGTTATGGGAGTTGTTAGCTATATTACCAGAAGAAGAGTTGAAGAGAGTTGATAGGGAGT
TAATTGAGAAGTATCATCCAAAATACAGAAAGAAATAA

Upstream 100 bases:

>100_bases
AAATCAAAAGAAATAATGGAGAAAATTAAGAATGAATTAGGTTCATTAAACTAAATTCCTTTCCTTAAAACTTTACAAAC
TCTTTATTTGAGGTGATGAT

Downstream 100 bases:

>100_bases
ATTCTAAATTTTAATTTTTAAACTTTTTTAAGATTTTTGATAATATTAATTTTAATTTATTTTTATTCATTTATATTTGT
ATATTGCCATACTTAAGTGT

Product: V-type ATP synthase subunit B

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit B

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MATAASAIEYSSVKSIAGPLLIVEGVEGAAYGEIVEVICPDGEKRMGQVLEAREGLAVVQVFEGTTGLSTKDTRVRFTGR
TAKIGVSMEMLGRIFNGAGKPIDGGPEIVPEKELDINGYPLNPVSRKVPSDFIQTGISTIDGMNTLVRGQKLPIFSGSGL
PHNQLAAQIARQAKVRGEGEKFAVVFAAMGITSEEANFFMEEFRKTGALERAVVFINLADDPAIERILTPRIALTVAEYL
AYEKDMHVLVILTDMTNYCEALREISAARNEVPGRRGYPGYMYTDLATIYERAGRVKGRTGTITQIPILTMPDDDITHPI
PDLTGYITEGQIVLSRELHRKGIYPPVDVLPSLSRLAGNGQGPGKTREDHKKVVNQAYAAYAEGRSLRDLVAVVGEEALT
DRDRAYLKFADEFEDKFVRQGKDEDRSIEETLDLLWELLAILPEEELKRVDRELIEKYHPKYRKK

Sequences:

>Translated_465_residues
MATAASAIEYSSVKSIAGPLLIVEGVEGAAYGEIVEVICPDGEKRMGQVLEAREGLAVVQVFEGTTGLSTKDTRVRFTGR
TAKIGVSMEMLGRIFNGAGKPIDGGPEIVPEKELDINGYPLNPVSRKVPSDFIQTGISTIDGMNTLVRGQKLPIFSGSGL
PHNQLAAQIARQAKVRGEGEKFAVVFAAMGITSEEANFFMEEFRKTGALERAVVFINLADDPAIERILTPRIALTVAEYL
AYEKDMHVLVILTDMTNYCEALREISAARNEVPGRRGYPGYMYTDLATIYERAGRVKGRTGTITQIPILTMPDDDITHPI
PDLTGYITEGQIVLSRELHRKGIYPPVDVLPSLSRLAGNGQGPGKTREDHKKVVNQAYAAYAEGRSLRDLVAVVGEEALT
DRDRAYLKFADEFEDKFVRQGKDEDRSIEETLDLLWELLAILPEEELKRVDRELIEKYHPKYRKK
>Mature_464_residues
ATAASAIEYSSVKSIAGPLLIVEGVEGAAYGEIVEVICPDGEKRMGQVLEAREGLAVVQVFEGTTGLSTKDTRVRFTGRT
AKIGVSMEMLGRIFNGAGKPIDGGPEIVPEKELDINGYPLNPVSRKVPSDFIQTGISTIDGMNTLVRGQKLPIFSGSGLP
HNQLAAQIARQAKVRGEGEKFAVVFAAMGITSEEANFFMEEFRKTGALERAVVFINLADDPAIERILTPRIALTVAEYLA
YEKDMHVLVILTDMTNYCEALREISAARNEVPGRRGYPGYMYTDLATIYERAGRVKGRTGTITQIPILTMPDDDITHPIP
DLTGYITEGQIVLSRELHRKGIYPPVDVLPSLSRLAGNGQGPGKTREDHKKVVNQAYAAYAEGRSLRDLVAVVGEEALTD
RDRAYLKFADEFEDKFVRQGKDEDRSIEETLDLLWELLAILPEEELKRVDRELIEKYHPKYRKK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913428, Length=466, Percent_Identity=57.725321888412, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI19913426, Length=462, Percent_Identity=57.5757575757576, Blast_Score=554, Evalue=1e-158,
Organism=Homo sapiens, GI32189394, Length=366, Percent_Identity=28.4153005464481, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI50345984, Length=359, Percent_Identity=27.0194986072423, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4757810, Length=359, Percent_Identity=27.0194986072423, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI19913424, Length=335, Percent_Identity=24.1791044776119, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788251, Length=329, Percent_Identity=30.3951367781155, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790170, Length=354, Percent_Identity=26.271186440678, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790172, Length=308, Percent_Identity=28.2467532467532, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=463, Percent_Identity=58.3153347732181, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17570191, Length=458, Percent_Identity=59.6069868995633, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI25144756, Length=366, Percent_Identity=28.1420765027322, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71988080, Length=293, Percent_Identity=25.5972696245734, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71988063, Length=293, Percent_Identity=25.5972696245734, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71988074, Length=269, Percent_Identity=25.2788104089219, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17565854, Length=316, Percent_Identity=23.7341772151899, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319603, Length=460, Percent_Identity=58.2608695652174, Blast_Score=561, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322581, Length=430, Percent_Identity=27.906976744186, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319370, Length=309, Percent_Identity=25.8899676375405, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320016, Length=251, Percent_Identity=25.8964143426295, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281361666, Length=463, Percent_Identity=57.8833693304536, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24646341, Length=463, Percent_Identity=57.8833693304536, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI17136796, Length=463, Percent_Identity=57.8833693304536, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24638766, Length=366, Percent_Identity=28.4153005464481, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28574560, Length=350, Percent_Identity=28.2857142857143, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24658560, Length=359, Percent_Identity=27.8551532033426, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24583992, Length=316, Percent_Identity=23.7341772151899, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129479, Length=324, Percent_Identity=24.3827160493827, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583988, Length=317, Percent_Identity=23.0283911671924, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583986, Length=317, Percent_Identity=23.0283911671924, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583984, Length=317, Percent_Identity=23.0283911671924, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): VATB_METJA (Q57669)

Other databases:

- EMBL:   L77117
- PIR:   A64327
- RefSeq:   NP_247185.1
- ProteinModelPortal:   Q57669
- SMR:   Q57669
- GeneID:   1451066
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0216
- NMPDR:   fig|243232.1.peg.222
- TIGR:   MJ0216
- HOGENOM:   HBG565875
- OMA:   RQAKVRG
- ProtClustDB:   PRK04196
- BioCyc:   MJAN243232:MJ_0216-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00310
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005724
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022879
- TIGRFAMs:   TIGR01041

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: 3.6.3.14

Molecular weight: Translated: 51375; Mature: 51244

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAASAIEYSSVKSIAGPLLIVEGVEGAAYGEIVEVICPDGEKRMGQVLEAREGLAVVQ
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHEECCCCHHHHHHHHHHHCCCEEEE
VFEGTTGLSTKDTRVRFTGRTAKIGVSMEMLGRIFNGAGKPIDGGPEIVPEKELDINGYP
EECCCCCCCCCCCEEEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
LNPVSRKVPSDFIQTGISTIDGMNTLVRGQKLPIFSGSGLPHNQLAAQIARQAKVRGEGE
CCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCC
KFAVVFAAMGITSEEANFFMEEFRKTGALERAVVFINLADDPAIERILTPRIALTVAEYL
EEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCHHHHHHHHHHH
AYEKDMHVLVILTDMTNYCEALREISAARNEVPGRRGYPGYMYTDLATIYERAGRVKGRT
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTITQIPILTMPDDDITHPIPDLTGYITEGQIVLSRELHRKGIYPPVDVLPSLSRLAGNG
CCEEEEEEEECCCCCCCCCCCCHHCEECCCEEEEHHHHHHCCCCCCHHHHHHHHHHCCCC
QGPGKTREDHKKVVNQAYAAYAEGRSLRDLVAVVGEEALTDRDRAYLKFADEFEDKFVRQ
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GKDEDRSIEETLDLLWELLAILPEEELKRVDRELIEKYHPKYRKK
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCC
>Mature Secondary Structure 
ATAASAIEYSSVKSIAGPLLIVEGVEGAAYGEIVEVICPDGEKRMGQVLEAREGLAVVQ
CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHEECCCCHHHHHHHHHHHCCCEEEE
VFEGTTGLSTKDTRVRFTGRTAKIGVSMEMLGRIFNGAGKPIDGGPEIVPEKELDINGYP
EECCCCCCCCCCCEEEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
LNPVSRKVPSDFIQTGISTIDGMNTLVRGQKLPIFSGSGLPHNQLAAQIARQAKVRGEGE
CCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCC
KFAVVFAAMGITSEEANFFMEEFRKTGALERAVVFINLADDPAIERILTPRIALTVAEYL
EEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCHHHHHHHHHHH
AYEKDMHVLVILTDMTNYCEALREISAARNEVPGRRGYPGYMYTDLATIYERAGRVKGRT
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTITQIPILTMPDDDITHPIPDLTGYITEGQIVLSRELHRKGIYPPVDVLPSLSRLAGNG
CCEEEEEEEECCCCCCCCCCCCHHCEECCCEEEEHHHHHHCCCCCCHHHHHHHHHHCCCC
QGPGKTREDHKKVVNQAYAAYAEGRSLRDLVAVVGEEALTDRDRAYLKFADEFEDKFVRQ
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GKDEDRSIEETLDLLWELLAILPEEELKRVDRELIEKYHPKYRKK
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087