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The map label for this gene is galE [C]

Identifier: 15668384

GI number: 15668384

Start: 202712

End: 203629

Strand: Direct

Name: galE [C]

Synonym: MJ0211

Alternate gene names: 15668384

Gene position: 202712-203629 (Clockwise)

Preceding gene: 15668383

Following gene: 15668385

Centisome position: 12.18

GC content: 30.94

Gene sequence:

>918_bases
ATGATATTAGTTACTGGAGGAGCAGGTTTTATTGGTAGTCATATAGTGGATAAACTAATCGAAAACAACTACGATGTAAT
TATCTTAGATAATTTAACAACAGGAAATAAAAATAACATAAATCCAAAGGCAGAGTTTGTAAATGCAGATATTAGAGATA
AAGACTTAGATGAAAAAATTAATTTTAAAGATGTTGAAGTTGTTATACATCAAGCAGCTCAAATAAACGTTAGAAATTCT
GTTGAAAATCCAGTATATGATGGAGACATCAATGTTTTAGGAACTATAAATATCTTAGAGATGATGAGAAAATACGATAT
AGATAAAATTGTATTCGCATCTTCTGGTGGAGCAGTTTATGGAGAACCAAATTATTTGCCAGTAGATGAAAATCATCCAA
TAAACCCATTATCTCCTTATGGGTTAAGTAAATACGTGGGAGAGGAATATATTAAGCTATACAACCGTTTATATGGAATT
GAATATGCAATTTTGAGATATTCAAATGTCTATGGAGAGAGGCAAGACCCAAAAGGAGAGGCTGGAGTTATAAGCATATT
TATAGATAAAATGTTAAAAAACCAAAGCCCAATTATTTTTGGAGATGGAAATCAAACAAGGGATTTTGTCTATGTTGGAG
ATGTAGCTAAAGCTAATTTAATGGCTTTAAATTGGAAGAATGAGATAGTAAATATTGGGACTGGAAAAGAGACATCAGTA
AATGAATTATTTGATATAATAAAGCATGAGATTGGGTTTAGAGGAGAAGCAATATATGATAAACCAAGAGAGGGAGAGGT
CTATAGAATTTATCTGGATATAAAAAAGGCAGAATCTTTAGGTTGGAAGCCAGAGATTGATTTAAAAGAGGGAATAAAGA
GAGTCGTTAATTGGATGAAAAATAATAATAGGACATAG

Upstream 100 bases:

>100_bases
ACTAACAACCCCAATACATAAGATAGTTATTAAAAAAGAAAAAGGCGTTGAAAATATACTAAAAAATTACTTAAAAAGAA
ATTAAATTGTTGGTGGAAAA

Downstream 100 bases:

>100_bases
CCTCATATTGTGATATATCCTATTAACTTTTAATGAAACTTTTTTAAAATCCGATGAAAGGTTTAAATAGATGATGAAAT
TATTTCTATATATCTTTAAT

Product: UDP-glucose 4-epimerase GalE

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNINPKAEFVNADIRDKDLDEKINFKDVEVVIHQAAQINVRNS
VENPVYDGDINVLGTINILEMMRKYDIDKIVFASSGGAVYGEPNYLPVDENHPINPLSPYGLSKYVGEEYIKLYNRLYGI
EYAILRYSNVYGERQDPKGEAGVISIFIDKMLKNQSPIIFGDGNQTRDFVYVGDVAKANLMALNWKNEIVNIGTGKETSV
NELFDIIKHEIGFRGEAIYDKPREGEVYRIYLDIKKAESLGWKPEIDLKEGIKRVVNWMKNNNRT

Sequences:

>Translated_305_residues
MILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNINPKAEFVNADIRDKDLDEKINFKDVEVVIHQAAQINVRNS
VENPVYDGDINVLGTINILEMMRKYDIDKIVFASSGGAVYGEPNYLPVDENHPINPLSPYGLSKYVGEEYIKLYNRLYGI
EYAILRYSNVYGERQDPKGEAGVISIFIDKMLKNQSPIIFGDGNQTRDFVYVGDVAKANLMALNWKNEIVNIGTGKETSV
NELFDIIKHEIGFRGEAIYDKPREGEVYRIYLDIKKAESLGWKPEIDLKEGIKRVVNWMKNNNRT
>Mature_305_residues
MILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNINPKAEFVNADIRDKDLDEKINFKDVEVVIHQAAQINVRNS
VENPVYDGDINVLGTINILEMMRKYDIDKIVFASSGGAVYGEPNYLPVDENHPINPLSPYGLSKYVGEEYIKLYNRLYGI
EYAILRYSNVYGERQDPKGEAGVISIFIDKMLKNQSPIIFGDGNQTRDFVYVGDVAKANLMALNWKNEIVNIGTGKETSV
NELFDIIKHEIGFRGEAIYDKPREGEVYRIYLDIKKAESLGWKPEIDLKEGIKRVVNWMKNNNRT

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI42516563, Length=306, Percent_Identity=30.0653594771242, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI7657641, Length=323, Percent_Identity=34.0557275541796, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI56237023, Length=338, Percent_Identity=31.3609467455621, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI56118217, Length=338, Percent_Identity=31.3609467455621, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI189083684, Length=338, Percent_Identity=31.3609467455621, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI116268111, Length=242, Percent_Identity=26.4462809917355, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786974, Length=332, Percent_Identity=31.0240963855422, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=31.1764705882353, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI48994969, Length=334, Percent_Identity=30.8383233532934, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1790049, Length=324, Percent_Identity=31.1728395061728, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788365, Length=331, Percent_Identity=24.4712990936556, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788366, Length=347, Percent_Identity=24.7838616714697, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788589, Length=335, Percent_Identity=26.2686567164179, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=312, Percent_Identity=31.4102564102564, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71982035, Length=344, Percent_Identity=31.3953488372093, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982038, Length=346, Percent_Identity=31.2138728323699, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17568069, Length=325, Percent_Identity=28.3076923076923, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532424, Length=321, Percent_Identity=27.4143302180685, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133901790, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133901786, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539422, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133901788, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=31.6715542521994, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321437, Length=354, Percent_Identity=24.8587570621469, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356223, Length=308, Percent_Identity=32.1428571428571, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI19923002, Length=340, Percent_Identity=30.5882352941176, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24158427, Length=281, Percent_Identity=26.6903914590747, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_METJA (Q57664)

Other databases:

- EMBL:   L77117
- PIR:   D64326
- RefSeq:   NP_247180.1
- ProteinModelPortal:   Q57664
- SMR:   Q57664
- GeneID:   1451061
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0211
- NMPDR:   fig|243232.1.peg.217
- TIGR:   MJ0211
- HOGENOM:   HBG755066
- OMA:   IVNIGTG
- ProtClustDB:   CLSK876112
- BioCyc:   MJAN243232:MJ_0211-MONOMER
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 34543; Mature: 34543

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: ACT_SITE 140-140 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNINPKAEFVNADIRDKDLDEKI
CEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHEEECCCCCCCCCCCC
NFKDVEVVIHQAAQINVRNSVENPVYDGDINVLGTINILEMMRKYDIDKIVFASSGGAVY
CCHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEECCCCEEE
GEPNYLPVDENHPINPLSPYGLSKYVGEEYIKLYNRLYGIEYAILRYSNVYGERQDPKGE
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCC
AGVISIFIDKMLKNQSPIIFGDGNQTRDFVYVGDVAKANLMALNWKNEIVNIGTGKETSV
CCCHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCEEEEEECCCCEEECCCCCCCCH
NELFDIIKHEIGFRGEAIYDKPREGEVYRIYLDIKKAESLGWKPEIDLKEGIKRVVNWMK
HHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHH
NNNRT
CCCCC
>Mature Secondary Structure
MILVTGGAGFIGSHIVDKLIENNYDVIILDNLTTGNKNNINPKAEFVNADIRDKDLDEKI
CEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHEEECCCCCCCCCCCC
NFKDVEVVIHQAAQINVRNSVENPVYDGDINVLGTINILEMMRKYDIDKIVFASSGGAVY
CCHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEECCCCEEE
GEPNYLPVDENHPINPLSPYGLSKYVGEEYIKLYNRLYGIEYAILRYSNVYGERQDPKGE
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCC
AGVISIFIDKMLKNQSPIIFGDGNQTRDFVYVGDVAKANLMALNWKNEIVNIGTGKETSV
CCCHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCEEEEEECCCCEEECCCCCCCCH
NELFDIIKHEIGFRGEAIYDKPREGEVYRIYLDIKKAESLGWKPEIDLKEGIKRVVNWMK
HHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHH
NNNRT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087