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The map label for this gene is purM

Identifier: 15668375

GI number: 15668375

Start: 194575

End: 195627

Strand: Direct

Name: purM

Synonym: MJ0203

Alternate gene names: 15668375

Gene position: 194575-195627 (Clockwise)

Preceding gene: 15668374

Following gene: 15668376

Centisome position: 11.69

GC content: 33.81

Gene sequence:

>1053_bases
ATGGTTACTTACAAAGATGCAGGAGTAGATATATCTCACGAAGATAAAGTAATTAAAGCCTTAGTTTCACAGATAACATT
TAAGAGAAGTGATATAAAACCAGCTGAGTTAGGATTGCACTATGCAGGAGCTGTTGAGTTTGGAGATTATTATTTAGTTT
TATCTACAGATGGTGTTGGAAGTAAGATGATAGTTGCAGAGATGGCTAATAAATTTGATACCGTTGGAATTGACATGATT
GCTATGAATGTAAATGATGCCATCTGTATTGGGGCAGAGCCTATAGCGTTGGTTGATTACTTAGCAGTTGGACATATAAC
CGAAGAGATAGCTGAGCAAATAGGAAAAGGATTAAATGAAGGAGCTAAAGAGGCAAATATAAACATTGTTGGTGGTGAAA
CAGCTACACTACCAGATATGATTAAAGGTATTGATTTAGCAGGAACTGTGTTAGCAATAGTTAAGAAGGATGAAATCATA
ACTGGAAAGGATGTTAAAGCTGGAGATGTGATTGTTGGTTTAAGAAGCTCTGGAATACATAGCAATGGGTTATCATTGGC
AAGGAAGGTATTTTTTGACATAGCTAAGTTAGACATTAATGACAAACTCTCTTATGGAAAGACAGTTGCTGAAGAGCTTT
TAACACCAACAAGGATTTATGTAAAGCCAGTTTTGGAGATGATTAGAGATAAAGATATAGAAGTTAAGGGTTTAGCCCAC
ATAACTGGAGGAAGTTTTAGAAAGCTTAAAAGATTGAATGATAAAGTAACTTACTATATTGACAACCTTCCAGAGCCATT
ACCAATATTTAAAGAGATTCAAAGATTGGGTAATGTGCCTGATGAAGAGATGTTTAGAACGTTTAATATGGGTATTGGAT
TCTGTGTAATTGTTGATGAAGAAGATGCCAACAAAGTTATAAAAATAGCTAATAAATATAATATCCCAGCCCAAGTAATA
GGTAGAGTTGTTGATAGCTTAGAGGTTAATGGAAATAAGATTGTTGGTAAAGCTGTTGTTAAATATAATGATAAGCATAT
AATATTAGAATAA

Upstream 100 bases:

>100_bases
TTCTGTAGTTTAAATATTCCATAATGCAAATTGGATGTTTAAAAAATTTTTATTCCTACAAAAATCGTATAGTTATTGAA
ACAAATAATGAGGAGATATT

Downstream 100 bases:

>100_bases
AAATAAATTATCTTTTTAATTTTACTAATTCTTCTTAATTTTCTTCTTTCTTTTTATTTATTTGCTAAAAGTCTAAAAAA
CTAAAAAAGGGTTTTTAATA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MVTYKDAGVDISHEDKVIKALVSQITFKRSDIKPAELGLHYAGAVEFGDYYLVLSTDGVGSKMIVAEMANKFDTVGIDMI
AMNVNDAICIGAEPIALVDYLAVGHITEEIAEQIGKGLNEGAKEANINIVGGETATLPDMIKGIDLAGTVLAIVKKDEII
TGKDVKAGDVIVGLRSSGIHSNGLSLARKVFFDIAKLDINDKLSYGKTVAEELLTPTRIYVKPVLEMIRDKDIEVKGLAH
ITGGSFRKLKRLNDKVTYYIDNLPEPLPIFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDEEDANKVIKIANKYNIPAQVI
GRVVDSLEVNGNKIVGKAVVKYNDKHIILE

Sequences:

>Translated_350_residues
MVTYKDAGVDISHEDKVIKALVSQITFKRSDIKPAELGLHYAGAVEFGDYYLVLSTDGVGSKMIVAEMANKFDTVGIDMI
AMNVNDAICIGAEPIALVDYLAVGHITEEIAEQIGKGLNEGAKEANINIVGGETATLPDMIKGIDLAGTVLAIVKKDEII
TGKDVKAGDVIVGLRSSGIHSNGLSLARKVFFDIAKLDINDKLSYGKTVAEELLTPTRIYVKPVLEMIRDKDIEVKGLAH
ITGGSFRKLKRLNDKVTYYIDNLPEPLPIFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDEEDANKVIKIANKYNIPAQVI
GRVVDSLEVNGNKIVGKAVVKYNDKHIILE
>Mature_350_residues
MVTYKDAGVDISHEDKVIKALVSQITFKRSDIKPAELGLHYAGAVEFGDYYLVLSTDGVGSKMIVAEMANKFDTVGIDMI
AMNVNDAICIGAEPIALVDYLAVGHITEEIAEQIGKGLNEGAKEANINIVGGETATLPDMIKGIDLAGTVLAIVKKDEII
TGKDVKAGDVIVGLRSSGIHSNGLSLARKVFFDIAKLDINDKLSYGKTVAEELLTPTRIYVKPVLEMIRDKDIEVKGLAH
ITGGSFRKLKRLNDKVTYYIDNLPEPLPIFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDEEDANKVIKIANKYNIPAQVI
GRVVDSLEVNGNKIVGKAVVKYNDKHIILE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=343, Percent_Identity=36.1516034985423, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI209869995, Length=343, Percent_Identity=36.1516034985423, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI209869993, Length=343, Percent_Identity=36.1516034985423, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=38.855421686747, Blast_Score=201, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17567511, Length=290, Percent_Identity=39.3103448275862, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321203, Length=319, Percent_Identity=36.0501567398119, Blast_Score=188, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24582400, Length=297, Percent_Identity=37.037037037037, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_METJA (Q57656)

Other databases:

- EMBL:   L77117
- PIR:   D64325
- RefSeq:   NP_247171.1
- ProteinModelPortal:   Q57656
- SMR:   Q57656
- GeneID:   1451052
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0203
- NMPDR:   fig|243232.1.peg.208
- TIGR:   MJ0203
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   MJAN243232:MJ_0203-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_A
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38203; Mature: 38203

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYKDAGVDISHEDKVIKALVSQITFKRSDIKPAELGLHYAGAVEFGDYYLVLSTDGVG
CCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCEEEECEEEECCEEEEEECCCCC
SKMIVAEMANKFDTVGIDMIAMNVNDAICIGAEPIALVDYLAVGHITEEIAEQIGKGLNE
CHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAKEANINIVGGETATLPDMIKGIDLAGTVLAIVKKDEIITGKDVKAGDVIVGLRSSGIH
CCCCCEEEEECCCCCCHHHHHHCCCHHHHEEEEEECCCEECCCCCCCCCEEEEECCCCCC
SNGLSLARKVFFDIAKLDINDKLSYGKTVAEELLTPTRIYVKPVLEMIRDKDIEVKGLAH
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEE
ITGGSFRKLKRLNDKVTYYIDNLPEPLPIFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDE
ECCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECC
EDANKVIKIANKYNIPAQVIGRVVDSLEVNGNKIVGKAVVKYNDKHIILE
CCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEC
>Mature Secondary Structure
MVTYKDAGVDISHEDKVIKALVSQITFKRSDIKPAELGLHYAGAVEFGDYYLVLSTDGVG
CCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCEEEECEEEECCEEEEEECCCCC
SKMIVAEMANKFDTVGIDMIAMNVNDAICIGAEPIALVDYLAVGHITEEIAEQIGKGLNE
CHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAKEANINIVGGETATLPDMIKGIDLAGTVLAIVKKDEIITGKDVKAGDVIVGLRSSGIH
CCCCCEEEEECCCCCCHHHHHHCCCHHHHEEEEEECCCEECCCCCCCCCEEEEECCCCCC
SNGLSLARKVFFDIAKLDINDKLSYGKTVAEELLTPTRIYVKPVLEMIRDKDIEVKGLAH
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEE
ITGGSFRKLKRLNDKVTYYIDNLPEPLPIFKEIQRLGNVPDEEMFRTFNMGIGFCVIVDE
ECCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECC
EDANKVIKIANKYNIPAQVIGRVVDSLEVNGNKIVGKAVVKYNDKHIILE
CCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087