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The map label for this gene is eif2b

Identifier: 15668268

GI number: 15668268

Start: 91045

End: 91476

Strand: Reverse

Name: eif2b

Synonym: MJ0097

Alternate gene names: 15668268

Gene position: 91476-91045 (Counterclockwise)

Preceding gene: 15668269

Following gene: 15668267

Centisome position: 5.49

GC content: 33.8

Gene sequence:

>432_bases
ATGAGCGACCTTGAAAATATTGACTATTATGATTATAAGGCATTATTAAAGAGAGCAAGAAGTCAGATTCCAGATTACGT
TTTCCAAAAAGATAGATTTGAACTTCCAGAAATTGAGATTTTGATAGAAGGAAATAGAACAATAATAAGAAACTTTAGAG
AGTTGGCTAAGGCAGTTAATAGAGATGAGGAATTCTTTGCTAAGTATCTTTTAAAAGAGACTGGTAGTGCTGGTAACTTA
GAGGGAGGTAGATTAATCTTACAGAGAAGAATCAGCCCAGAGTTATTAAAATCAAGAATTAATGACTTCTTGAGGGAGTA
TGTTATCTGTAGAGAGTGCGGTAAGCCAGATACCAAGATTATTAAGGAGGGAAGAGTTCATTTACTCAAATGTATGGCTT
GTGGTGCTATAAGACCAATAAGAATGATTTAA

Upstream 100 bases:

>100_bases
ATAAATTTTGAAAGACACTATATTACCATTTGGCAATTGGGATAGTTTTTTATATAAATTAAAAGTTATAGTTTTTTGAT
AATCTTATTTTGGTGATAAA

Downstream 100 bases:

>100_bases
ATACCATAGGAGGATGCCTCCTATTGGGATATCACATGTCCATTAAGTTGCCCCTTACAGGGGCAATTAATGTCCAATAG
GTTGGAATCCCTTTCTACGA

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MSDLENIDYYDYKALLKRARSQIPDYVFQKDRFELPEIEILIEGNRTIIRNFRELAKAVNRDEEFFAKYLLKETGSAGNL
EGGRLILQRRISPELLKSRINDFLREYVICRECGKPDTKIIKEGRVHLLKCMACGAIRPIRMI

Sequences:

>Translated_143_residues
MSDLENIDYYDYKALLKRARSQIPDYVFQKDRFELPEIEILIEGNRTIIRNFRELAKAVNRDEEFFAKYLLKETGSAGNL
EGGRLILQRRISPELLKSRINDFLREYVICRECGKPDTKIIKEGRVHLLKCMACGAIRPIRMI
>Mature_142_residues
SDLENIDYYDYKALLKRARSQIPDYVFQKDRFELPEIEILIEGNRTIIRNFRELAKAVNRDEEFFAKYLLKETGSAGNLE
GGRLILQRRISPELLKSRINDFLREYVICRECGKPDTKIIKEGRVHLLKCMACGAIRPIRMI

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family

Homologues:

Organism=Homo sapiens, GI29826335, Length=134, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508049, Length=115, Percent_Identity=29.5652173913043, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6325018, Length=115, Percent_Identity=26.9565217391304, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647377, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2B_METJA (Q57562)

Other databases:

- EMBL:   L77117
- PIR:   A64312
- RefSeq:   NP_247061.1
- PDB:   1K81
- PDB:   1K8B
- PDBsum:   1K81
- PDBsum:   1K8B
- ProteinModelPortal:   Q57562
- SMR:   Q57562
- GeneID:   1450936
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0097
- NMPDR:   fig|243232.1.peg.98
- TIGR:   MJ0097
- HOGENOM:   HBG738095
- OMA:   FLKCEAC
- ProtClustDB:   PRK03988
- BioCyc:   MJAN243232:MJ_0097-MONOMER
- HAMAP:   MF_00232
- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190
- SMART:   SM00653
- TIGRFAMs:   TIGR00311

Pfam domain/function: PF01873 eIF-5_eIF-2B; SSF100966 Transl_init_fac_IF2/IF5_N; SSF75689 Transl_init_fac_IF2/IF5_Zn-bd

EC number: NA

Molecular weight: Translated: 16797; Mature: 16666

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLENIDYYDYKALLKRARSQIPDYVFQKDRFELPEIEILIEGNRTIIRNFRELAKAVN
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHC
RDEEFFAKYLLKETGSAGNLEGGRLILQRRISPELLKSRINDFLREYVICRECGKPDTKI
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IKEGRVHLLKCMACGAIRPIRMI
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDLENIDYYDYKALLKRARSQIPDYVFQKDRFELPEIEILIEGNRTIIRNFRELAKAVN
CCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHC
RDEEFFAKYLLKETGSAGNLEGGRLILQRRISPELLKSRINDFLREYVICRECGKPDTKI
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IKEGRVHLLKCMACGAIRPIRMI
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087