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Identifier: 15646180

GI number: 15646180

Start: 1653857

End: 1654621

Strand: Reverse

Name: Not Available

Synonym: HP1573

Alternate gene names: 15646180

Gene position: 1654621-1653857 (Counterclockwise)

Preceding gene: 15646185

Following gene: 15646179

Centisome position: 99.21

GC content: 39.08

Gene sequence:

>765_bases
ATGTTTATAGACACGCATTGCCATTTGGATCACAAGGACTATGAAAACGATTTAGAAGAAGTGTTAAAAGAAAGCCTAGA
AAAAGGCGTTACTCAATGCGTGATTCCTGGCGCGGACATGAAGGATTTGAATAGAGCAATAGAAATTAGCGAAAAATTTG
AAGGCGTGTTTTTTGCCATAGGCGCTCACCCTTATGATGTGGAGAGTTTTGATGAAAGCCTGTTTGAAAAGTTCGTTGGG
CATCAAAAATGCGTGGCGATAGGCGAATGCGGACTGGATTACTACCGCTTGCCTGAATTGAATGAAAGAGAGAATTATAA
AAGCAAGCAAAAAGAAATTTTCACCAAACAGATTGAATTTTCTATCCAACACAACAAGCCCTTGATTATCCATATTAGAG
AGGCGAGTTTTGATAGTTTGAATCTTTTAAAAAACTATCCTAAGGCTTTTGGGGTGTTGCATTGCTTTAACGCTGATGGC
ATGCTTTTGGAATTAAGCGATCGTTTTTACTATGGGATAGGAGGGGTTAGCACTTTTAAAAACGCTAAAAGACTGGTAGA
GATCCTCCCTAAAATCCCTAAAAACAGGCTTCTTTTAGAAACGGATTCGCCTTATTTGACCCCACACCCTTTTAGAGGTA
CTAGGAATAGCCCTACTTATATCCCTTTAATCGCTCAAAAAATTGCTGAAATCATCAACATAGAGACTGAAGAACTCGCT
TCTTTAAGCACGCATAACGCTCAAATGCTCTTTAGTTTCCCCTAA

Upstream 100 bases:

>100_bases
ATTTGATGGATTAGACCGCTGAACATAATTGATTGTTATTCTCCTTATGTTAGAATGTTTGATTATTGTAACATACTAAA
TAAAACCATAGGATAAAAGC

Downstream 100 bases:

>100_bases
AATAAGGCTGTGTTAGAAAGCGTTATTCAAGTTTAGTTATAATCAAAGCTATTTTAAAAGCTGAATAGCTATAGTTATTA
GGATGCGATGTCAAAAAGAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MFIDTHCHLDHKDYENDLEEVLKESLEKGVTQCVIPGADMKDLNRAIEISEKFEGVFFAIGAHPYDVESFDESLFEKFVG
HQKCVAIGECGLDYYRLPELNERENYKSKQKEIFTKQIEFSIQHNKPLIIHIREASFDSLNLLKNYPKAFGVLHCFNADG
MLLELSDRFYYGIGGVSTFKNAKRLVEILPKIPKNRLLLETDSPYLTPHPFRGTRNSPTYIPLIAQKIAEIINIETEELA
SLSTHNAQMLFSFP

Sequences:

>Translated_254_residues
MFIDTHCHLDHKDYENDLEEVLKESLEKGVTQCVIPGADMKDLNRAIEISEKFEGVFFAIGAHPYDVESFDESLFEKFVG
HQKCVAIGECGLDYYRLPELNERENYKSKQKEIFTKQIEFSIQHNKPLIIHIREASFDSLNLLKNYPKAFGVLHCFNADG
MLLELSDRFYYGIGGVSTFKNAKRLVEILPKIPKNRLLLETDSPYLTPHPFRGTRNSPTYIPLIAQKIAEIINIETEELA
SLSTHNAQMLFSFP
>Mature_254_residues
MFIDTHCHLDHKDYENDLEEVLKESLEKGVTQCVIPGADMKDLNRAIEISEKFEGVFFAIGAHPYDVESFDESLFEKFVG
HQKCVAIGECGLDYYRLPELNERENYKSKQKEIFTKQIEFSIQHNKPLIIHIREASFDSLNLLKNYPKAFGVLHCFNADG
MLLELSDRFYYGIGGVSTFKNAKRLVEILPKIPKNRLLLETDSPYLTPHPFRGTRNSPTYIPLIAQKIAEIINIETEELA
SLSTHNAQMLFSFP

Specific function: Unknown

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI110349730, Length=264, Percent_Identity=26.8939393939394, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI110349734, Length=266, Percent_Identity=27.4436090225564, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI226061853, Length=274, Percent_Identity=27.007299270073, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI226061614, Length=251, Percent_Identity=26.2948207171315, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI225903424, Length=262, Percent_Identity=28.6259541984733, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI14042943, Length=281, Percent_Identity=28.8256227758007, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI226061595, Length=231, Percent_Identity=25.5411255411255, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI225903439, Length=261, Percent_Identity=28.735632183908, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787342, Length=271, Percent_Identity=37.2693726937269, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI48994985, Length=268, Percent_Identity=29.1044776119403, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082439, Length=266, Percent_Identity=27.8195488721804, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17559024, Length=290, Percent_Identity=27.9310344827586, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71980746, Length=262, Percent_Identity=28.6259541984733, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17565396, Length=303, Percent_Identity=26.7326732673267, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17543026, Length=193, Percent_Identity=28.4974093264249, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648690, Length=290, Percent_Identity=30.3448275862069, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221330018, Length=243, Percent_Identity=29.2181069958848, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24586117, Length=243, Percent_Identity=29.2181069958848, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278
- InterPro:   IPR015991 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 29178; Mature: 29178

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01137 TATD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIDTHCHLDHKDYENDLEEVLKESLEKGVTQCVIPGADMKDLNRAIEISEKFEGVFFAI
CEECCEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCEEEEEE
GAHPYDVESFDESLFEKFVGHQKCVAIGECGLDYYRLPELNERENYKSKQKEIFTKQIEF
CCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCEECCCCCCHHHHHHHHHHHHHHHHEE
SIQHNKPLIIHIREASFDSLNLLKNYPKAFGVLHCFNADGMLLELSDRFYYGIGGVSTFK
EEECCCCEEEEEECCCCCHHHHHHHCHHHHCEEEEECCCCEEEEECCCEEEECCCHHHHH
NAKRLVEILPKIPKNRLLLETDSPYLTPHPFRGTRNSPTYIPLIAQKIAEIINIETEELA
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
SLSTHNAQMLFSFP
HHCCCCCEEEEECC
>Mature Secondary Structure
MFIDTHCHLDHKDYENDLEEVLKESLEKGVTQCVIPGADMKDLNRAIEISEKFEGVFFAI
CEECCEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCEEEEEE
GAHPYDVESFDESLFEKFVGHQKCVAIGECGLDYYRLPELNERENYKSKQKEIFTKQIEF
CCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCEECCCCCCHHHHHHHHHHHHHHHHEE
SIQHNKPLIIHIREASFDSLNLLKNYPKAFGVLHCFNADGMLLELSDRFYYGIGGVSTFK
EEECCCCEEEEEECCCCCHHHHHHHCHHHHCEEEEECCCCEEEEECCCEEEECCCHHHHH
NAKRLVEILPKIPKNRLLLETDSPYLTPHPFRGTRNSPTYIPLIAQKIAEIINIETEELA
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
SLSTHNAQMLFSFP
HHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]