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Identifier: 15646163

GI number: 15646163

Start: 1637996

End: 1639843

Strand: Reverse

Name: Not Available

Synonym: HP1556

Alternate gene names: 15646163

Gene position: 1639843-1637996 (Counterclockwise)

Preceding gene: 15646164

Following gene: 15646160

Centisome position: 98.32

GC content: 39.45

Gene sequence:

>1848_bases
ATGGATAATAGGAATATTGATCCTTACTTCAACCCAGAGCAATTTTTAGAAACCCAAAAATACAAAGGCACGGTTACAGC
ATTAATCTTTTTATTGCTTTTTTTTATTTTTTTAATGGTGGCTTTTAAAAAAGCTTTTTTTGCCCAAGCCAACATGCCTA
ATCTAGTGATGAGCAAACAAGACACTGCGGCTAGGGGGACTATCTATAGTCAAGACAACTACAGCCTAGCCACTTCACAA
ACCCTTTTCAAACTGGGCTTTGATACAAGGTTTTTAAACCCGGATAAAGAAGATTTTTTCATTGATTTCCTTTCTATTTA
TAGCAATATCCCTAAAAAGTCCTTAAAAGACGCCATCAATACAAAAGGCTATATCATTCTAGCCTATGATCTCACGCCCA
ATATGGCTGCTAATATTAGAGACTTAAATAAGAAATTTTTAGCCTTTGGGGTTTTTCAAAATTTCAAAGACGCGCACGAT
AAGGTGTGGCAAAAGCAAGGGCTAAACATTGAAGTGAGCGGCGTTTCTAGGCATTACCCTTATCAAAATAGCCTAGAGCC
AATCATTGGCTATGTGCAAAAACAAGAAGAAGACAAGCTCACTTTAACTACCGGTAAAAAAGGCGTTGAAAAATCTCAAG
ATCACTTGCTTAAAGCCCAACAAAATGGCATAAGAACAGGCAAAAGAGACGTGAGTTTTAACTTTATCCAAAACCACTCT
TATACAGAGGTTGAACGCCTTGATGGCTATGAGGTGTATTTGAGCGTTCCTTTAAAACTCCAAAGAGAAATTGAAACCCT
ATTGGATAAAACTAAAGACAAACTCAAGGCTAAAGAAATCCTAGTGGGTATCATTAACCCTAAAAGCGGGGAAATTTTAT
CGCTAGCTTCAAGCAAGCGCTTCAATCCTAATGCGATTAAAACCAGCGATTATGAAAGCTTGAATTTGAGCGTTGCTGAA
AAGGTTTTTGAGCCAGGCAGCACGATCAAACCCATTGTTTATTCCTTGCTGTTAGACAAGAATTTGATCAACCCCAAAGA
ACGCATTGATTTAAACCATGGCTATTACCAATTAGGAAAATACACCATTAAAGACGACTTTATCCCCAGTAAAAAAGCCG
TTGTGGAAGACATTTTGATCCAATCTAGCAATGTGGGCATGATAAAAATCAGTAAAAACTTAAACCCAAAGGATTTCTAT
AATGGGCTTTTAGGCTATGGATTTTCTCAAAAAACCGGCATTGATTTATCTCTAGAAGCCACAGGAAAGATCCCTCCTTT
GTCCGCTTTCAAGCGTGAAGTGTTAAAGGGGAGCGTTTCTTATGGCTATGGGCTGAACGCGACTTTTTTGCAGCTTTTAA
GGGCTTATGCGGTGTTTTCTAATGAAGGCAAATTGACTACCCCCTATTTAGTGCAACGAGAAACCGCCCCTAATGGCGAT
ATTTACATCCCTAGCCCCAAACCCACCTTTCAAGTCATTAGCCCAAAAAGCGCTAGGAAAATGAAAGAAACCTTAATCAA
AGTAGTGCGTTATGGCACAGGCAAAAACGCTCAATTTGAAGGGCTATACATAGGGGGCAAAACCGGCACGGCTAGGGTCG
CTAAAAACGGGAGTTATAGCGCGCAGTCCTACAACAGCTCTTTTTTTGGGTTTGCTGAAGATGAAAGGCAGGTTTTTACT
ATCGGCGTGGTTATCTTAGGTTCGCATGGCAAGGAAGAATATTACGCCAGCAAGATTGCAGCCCCCATTTTTAAAGAAAT
CACCGAAATTTTAGTGCGTTACAATTATCTATCGCCCTCTATTGCGATTCAAAACGCGCTCGAGAAAAACCGCTTTAAGA
TAAAATAA

Upstream 100 bases:

>100_bases
TGTTGTTGCTACACCCCATTTTAACGGATTTTACCATCAAAAATTCATGCTCTCATGCGTTGTGAAAATCCAACGCCACG
CCATTTTCAAGTAAGTGCTT

Downstream 100 bases:

>100_bases
AAGGCTCTTTTCAACCCAAACTCCAAAAAAGGAGTCTTAAGTTGCCGGATCTGTGGCATTAAGGCCAAATTTAGAGGACA
GATTAGAAAAAATCTGTTTA

Product: cell division protein (ftsI)

Products: NA

Alternate protein names: PBP-2B; Penicillin-binding protein B [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MDNRNIDPYFNPEQFLETQKYKGTVTALIFLLLFFIFLMVAFKKAFFAQANMPNLVMSKQDTAARGTIYSQDNYSLATSQ
TLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYIILAYDLTPNMAANIRDLNKKFLAFGVFQNFKDAHD
KVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
YTEVERLDGYEVYLSVPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSKRFNPNAIKTSDYESLNLSVAE
KVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPKDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSAQSYNSSFFGFAEDERQVFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRFKIK

Sequences:

>Translated_615_residues
MDNRNIDPYFNPEQFLETQKYKGTVTALIFLLLFFIFLMVAFKKAFFAQANMPNLVMSKQDTAARGTIYSQDNYSLATSQ
TLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYIILAYDLTPNMAANIRDLNKKFLAFGVFQNFKDAHD
KVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
YTEVERLDGYEVYLSVPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSKRFNPNAIKTSDYESLNLSVAE
KVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPKDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSAQSYNSSFFGFAEDERQVFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRFKIK
>Mature_615_residues
MDNRNIDPYFNPEQFLETQKYKGTVTALIFLLLFFIFLMVAFKKAFFAQANMPNLVMSKQDTAARGTIYSQDNYSLATSQ
TLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYIILAYDLTPNMAANIRDLNKKFLAFGVFQNFKDAHD
KVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
YTEVERLDGYEVYLSVPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSKRFNPNAIKTSDYESLNLSVAE
KVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPKDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSAQSYNSSFFGFAEDERQVFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRFKIK

Specific function: Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. PBP-2B is required for vegetative cell division and sporulation septation. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active sit

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PASTA domains [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=600, Percent_Identity=25.5, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786854, Length=478, Percent_Identity=25.7322175732218, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69440; Mature: 69440

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRNIDPYFNPEQFLETQKYKGTVTALIFLLLFFIFLMVAFKKAFFAQANMPNLVMSKQ
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
DTAARGTIYSQDNYSLATSQTLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAIN
CCHHCCEEEECCCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHC
TKGYIILAYDLTPNMAANIRDLNKKFLAFGVFQNFKDAHDKVWQKQGLNIEVSGVSRHYP
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
YQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
CCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
YTEVERLDGYEVYLSVPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSKR
CCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEECCCCC
FNPNAIKTSDYESLNLSVAEKVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGK
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHEECCCCEEEECC
YTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPKDFYNGLLGYGFSQKTGIDLSLEA
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEC
TGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYS
EECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCC
AQSYNSSFFGFAEDERQVFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPS
CCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IAIQNALEKNRFKIK
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MDNRNIDPYFNPEQFLETQKYKGTVTALIFLLLFFIFLMVAFKKAFFAQANMPNLVMSKQ
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
DTAARGTIYSQDNYSLATSQTLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAIN
CCHHCCEEEECCCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHC
TKGYIILAYDLTPNMAANIRDLNKKFLAFGVFQNFKDAHDKVWQKQGLNIEVSGVSRHYP
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
YQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
CCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
YTEVERLDGYEVYLSVPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSKR
CCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEECCCCC
FNPNAIKTSDYESLNLSVAEKVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGK
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHEECCCCEEEECC
YTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPKDFYNGLLGYGFSQKTGIDLSLEA
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEC
TGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYS
EECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCC
AQSYNSSFFGFAEDERQVFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPS
CCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IAIQNALEKNRFKIK
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8244929; 9384377; 8289242 [H]