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The map label for this gene is dnaA

Identifier: 15646137

GI number: 15646137

Start: 1607624

End: 1608997

Strand: Reverse

Name: dnaA

Synonym: HP1529

Alternate gene names: 15646137

Gene position: 1608997-1607624 (Counterclockwise)

Preceding gene: 15646142

Following gene: 15646135

Centisome position: 96.47

GC content: 40.25

Gene sequence:

>1374_bases
ATGGATACCAACAACAATATTGAAAAAGAAATCTTGGCGCTAGTCAAACAAAATCCTAAAGTTAGTCTCATAGAGTATGA
AAATTACTTTAGCCAACTCAAATACAACCCTAACGCAAGCAAGAGCGATATTGCCTTTTTTTATGCCCCCAACCAAGTCT
TATGCACCACGATTACAGCTAAATACGGCGCGTTGCTTAAAGAAATTTTAAGCCAGAATAAAGTCGGCATGCATTTAGCC
CACAGCGTGGATGTGCGTATTGAAGTAGCGCCTAAAATCCAAATTAACGCCCAATCTAATATCAATTACAAAGCCATAAA
AACGAGCGTCAAAGACTCTTACACTTTTGAAAATTTTGTCGTAGGCTCATGCAATAACACCGTTTATGAAATCGCTAAAA
AAGTCGCCCAAAGCGATACCCCCCCTTATAACCCGGTGCTTTTTTATGGCGGCACAGGGTTAGGCAAAACGCACATTTTA
AACGCTATCGGCAACCATGCCCTAGAAAAGCATAAAAAAGTCGTGTTAGTCACTTCAGAAGACTTTTTGACAGACTTTTT
AAAGCATTTAGACAACAAAACCATGGATTCTTTTAAAGCAAAATACCGCCATTGCGACTTTTTCTTGTTAGATGACGCTC
AATTTTTGCAAGGAAAACCCAAGCTAGAAGAAGAATTTTTCCACACCTTTAACGAATTGCACGCCAACAGCAAACAAATC
GTATTGATTTCAGACCGATCGCCTAAAAACATCGCCGGCTTAGAAGATCGCTTAAAATCGCGCTTTGAATGGGGGATAAC
CGCTAAAGTCATGCCCCCTGATTTAGAAACCAAACTTTCCATTGTCAAACAAAAATGCCAGCTCAATCAAATCACTTTGC
CTGAAGAGGTGATGGAATACATCGCCCAACACATCAGCGACAATATCCGCCAAATGGAAGGCGCGATCATTAAAATCAGC
GTGAACGCGAACTTGATGAACGCTTCCATTGATTTGAACCTCGCTAAAACCGTTTTAGAAGATTTGCAAAAAGATCATGC
TGAAGGTTCAAGCTTGGAAAATATCCTACTCGCTGTCGCGCAAAGCCTGAATCTCAAATCCAGCGAAATCAAAGTCTCTT
CGCGCCAAAAAAATGTCGCTTTGGCGAGGAAATTAGTCGTGTATTTCGCCAGGCTTTATACCCCTAACCCCACGCTCTCG
CTCGCTCAATTTTTGGATTTAAAGGATCATTCAAGCATTTCTAAAATGTATTCTGGCGTTAAAAAAATGCTTGAAGAAGA
AAAAAGCCCTTTTGTCTTAAGCCTTAGAGAAGAAATCAAAAACCGCTTGAACGAATTGAACGACAAAAAAACCGCTTTCA
ATTCAAGTGAATGA

Upstream 100 bases:

>100_bases
AAACCCTTAAAAGAAACACCTTAATTTTAAGGCTTCATTCACATTTCATTCACATGTTATTCCTTTTTCATTCACCACTT
ATTCACGCTATAATAACGCC

Downstream 100 bases:

>100_bases
AAAAAGGCTTATGAAAAAGCGTTTCATTCACTTCTTTTCAAATCCCACAACCCCCCTAAAAACGCACACCTCTAAAGCTT
TTTATTGTTTCATTCCATCC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITAKYGALLKEILSQNKVGMHLA
HSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHIL
NAIGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQI
VLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEYIAQHISDNIRQMEGAIIKIS
VNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLS
LAQFLDLKDHSSISKMYSGVKKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE

Sequences:

>Translated_457_residues
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITAKYGALLKEILSQNKVGMHLA
HSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHIL
NAIGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQI
VLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEYIAQHISDNIRQMEGAIIKIS
VNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLS
LAQFLDLKDHSSISKMYSGVKKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE
>Mature_457_residues
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITAKYGALLKEILSQNKVGMHLA
HSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHIL
NAIGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQI
VLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEYIAQHISDNIRQMEGAIIKIS
VNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLS
LAQFLDLKDHSSISKMYSGVKKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=322, Percent_Identity=37.5776397515528, Blast_Score=243, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 51684; Mature: 51684

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITA
CCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEHHHH
KYGALLKEILSQNKVGMHLAHSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFV
HHHHHHHHHHCCCCCCEEEEEEEEEEEEEECEEEEECCCCCCHHHHHHHHCCCCCCCCEE
VGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSE
EECCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECH
DFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQI
HHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHHHHHHCCCCCEE
VLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEY
EEEECCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
IAQHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVA
HHHHHHHHHHHHCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSGV
HHCCCCCHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHH
KKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE
HHHHHHCCCCEEEHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure
MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITA
CCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEHHHH
KYGALLKEILSQNKVGMHLAHSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFV
HHHHHHHHHHCCCCCCEEEEEEEEEEEEEECEEEEECCCCCCHHHHHHHHCCCCCCCCEE
VGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSE
EECCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECH
DFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQI
HHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHHHHHHCCCCCEE
VLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEY
EEEECCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
IAQHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVA
HHHHHHHHHHHHCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSGV
HHCCCCCHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHH
KKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE
HHHHHHCCCCEEEHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]