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Identifier: 15646079

GI number: 15646079

Start: 1540697

End: 1543375

Strand: Reverse

Name: Not Available

Synonym: HP1470

Alternate gene names: 15646079

Gene position: 1543375-1540697 (Counterclockwise)

Preceding gene: 15646080

Following gene: 15646078

Centisome position: 92.54

GC content: 38.75

Gene sequence:

>2679_bases
ATGATGGAGCAGCCAGTCATTAAAGAAGGGACTTTAGCTTTAATTGATACTTTTGCGTATTTGTTTAGAAGCTATTACAT
GAGCGCTAAAAATAAGCCTTTAACCAACGATAAGGGCTTTCCTACAGGGCTTTTAACGGGGCTTGTGGGCATGGTTAAAA
AATTTTATAAAGACAGAAAAAACATGCCTTTTATCGTGTTCGCTTTAGAAAGCCAGACTAAAACTAAAAGAGCCGAAAAA
TTAGGCGAATACAAACAAAATCGTAAAGACGCCCCCAAAGAGATGCTTTTACAAATCCCTATCGCCTTAGAATGGTTGCA
AAAAATGGGTTTTGTTTGCGTGGAGGTGAATGGGTTTGAAGCTGATGATGTTATCGCAAGCCTAGCCACGCTAAGCCCTT
ATAAAACCCGTATTTATTCTAAAGATAAGGATTTTAACCAGCTTTTGAGCGATAAAATCGCGCTTTTTGATGGCAAAACG
GAGTTTTTGGCGAAAGATTGCGTGGAAAAATACGGGATTTTGCCGAGTCAATTCACGGATTATCAAGGCATTGTGGGGGA
TAGCAGCGATAATTACAAGGGGGTTAAAGGCATTGGGAGCAAGAACGCTAAGGAATTGTTGCAGCGATTAGGGAGCTTGG
AAAAAATCTATGAAAATTTAGACTTGGCGAAAAATTTACTCAGCCCTAAAATGTATCGAGCCCTGATACACGACAAAGCA
AGCGCGTTTTTAAGCAAAGAATTAGCCACTTTAGAAAGAGGATGCATTAAAGAATTTGATTTTTTAAGTTGCGCTTTTCC
TAGCGAAAACCCCTTATTGAAAATTAAAGATGAATTGAAAGAATATGGTTTCATTTCTACTTTAAGGGATTTAGAGAATT
CCCCTACGCCTTTAATTTTAGACAACGCCCCCCTATTAGACAACACGCCCGCCTTAGACAACACCCCTAAAAAATCATGC
ATGATCGTTTTGGAAAGCGCCGCACCTTTGAGCGCGTTTTTAGAAAAACTAGAAAAAACTAACGCAAGGGTTTTTGCGCG
TTTGGTGCTGGATAAAGAAAAAAAAGTTCTGGCCCTAGCGTTTTTATATGAAGATCAAGGCTATTTTTTACCTTTAGAAG
AGGCGTTATTTTCGCCCTTTTCTTTAGAGTTTTTGCAAAACGCTTTTTTTAAAATGTTACAGCATGCGCAAATCATTGGG
CATGATTTAAAACCCTTGTTGAGCTTTTTAAAAGCCAAATACCAGGTGCCTTTAGAAAACATTCGCATCCAAGACACTCA
AATTTTAGCGTTTTTAAAAAATCCGGAAAAAGTGGGGTTTGATGAAGTTTTAAAGGAATATTTAAAAGAAGAATTGATTC
CGCATGAAAAAATCAAAGATTTTAAGACTAAAGCGGAGAAATTGGAACTTTTAAGCGTGGAATTAAACGCTTTAAAGCGT
TTGTGTGAATATTTTGAAAAGGGGGGATTGGAAGAAAACTTGCTTTCTTTGGCCAGAGAAATTGAAACGCCCTTTATGAA
AGTTTTAATGGGCATGGAGTTTCAAGGCTTTAAGATTGATGCGCCTTATTTCAAGCGCTTAGAGCAGGAGTTTAAGAATG
AATTGCATGTTTTAGAGCGCCAAATTTTGGAACTAATTGGCGTGGATTTTAACCTCAATTCGCCCAAGCAACTTAGCGAA
GTCTTGTATGATAAATTAGGGCTTCCTAAAAACAAAAGCCATTCTACCGATGAAAAAAGCCTGTTAAAAATCCTAGACAA
GCATCCAAGCATCGCTTTGATTTTAGAATACAGAGAATTGAACAAGCTTTTTAACACTTATACCACCCCCTTATTGCGCC
TAAAAGACAAAGACGATAAAATCCATACCACTTTTATCCAAACCGGCACAGCTACCGGGCGTTTAAGCTCGCATTCGCCT
AATTTGCAAAATATCCCAGTGCGATCGCCTAAGGGCTTACTCATTCGTAAAGGCTTTATCGCCAGCTCTAAAGAGTATTG
TTTGCTAGGGGTGGATTATTCGCAGATTGAATTGCGCTTATTAGCCCATTTCAGCCAGGATAAGGATTTAATGGAGGCGT
TTTTAAAGGGGCGAGACATCCATTTAGAAACTTCTAAGGCGTTGTTTGGAGAATATTTGGCTAAAGAAAAACGATCCATC
GCTAAAAGCATTAATTTTGGGCTGGTGTATGGCATGGGGAGTAAGAAATTGAGCGAAACTTTAAACATCTCTTTAAATGA
GGCTAAAAGCTACATAGAAGCGTATTTCAAACGATTCCCTAGTATTAAAGATTATTTAAACCGCATGAAAGAAGAGATTT
TAAAAACTTCTAAAGCCTTCACTTTGCTTGGGCGTTATCGGGTGTTTGATTTTACCGGCGCAAATGACTATGTTAAGGGC
AATTATTTGCGAGAGGGCGTGAATGCGATTTTTCAAGGGAGCGCTAGCGATTTATTGAAATTAGGCATGCTCAAAGTGAG
CGAGCGTTTCAAAAATAACCCTTCAGTTAGGCTGCTTTTGCAAGTGCATGACGAATTGATTTTTGAGATTGAAGAAAAAA
ACGCCCCAGAGTTGCAGCAAGAAATCCAACGCATTCTCAATGATGAAGTGTATCCTTTGAGGGTGCCGTTAGAAACGAGC
GCGTTTATCGCTAAGCGTTGGAATGAATTAAAAGGTTAG

Upstream 100 bases:

>100_bases
GAAGCGCCCGTTCAAAAAGACTCGTTATTTTAAAAGGGGTTTTAAGCGCGCTAGCTTGTGTTACAATAAACTTAAAATTC
GCTTGATTGAAGAGGGTTGA

Downstream 100 bases:

>100_bases
TTTTTTAATTGAGTTTAAGAAAAAATATATTATTATTTCTTTATAAGTAATACTTAGCCATTTTAAGCTAATATAATATA
GAGCGATTATCAAAAAATAA

Product: DNA polymerase I (polA)

Products: NA

Alternate protein names: POL I [H]

Number of amino acids: Translated: 892; Mature: 892

Protein sequence:

>892_residues
MMEQPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAEK
LGEYKQNRKDAPKEMLLQIPIALEWLQKMGFVCVEVNGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKT
EFLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYRALIHDKA
SAFLSKELATLERGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILDNAPLLDNTPALDNTPKKSC
MIVLESAAPLSAFLEKLEKTNARVFARLVLDKEKKVLALAFLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIG
HDLKPLLSFLKAKYQVPLENIRIQDTQILAFLKNPEKVGFDEVLKEYLKEELIPHEKIKDFKTKAEKLELLSVELNALKR
LCEYFEKGGLEENLLSLAREIETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKNELHVLERQILELIGVDFNLNSPKQLSE
VLYDKLGLPKNKSHSTDEKSLLKILDKHPSIALILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSP
NLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFGEYLAKEKRSI
AKSINFGLVYGMGSKKLSETLNISLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDYVKG
NYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETS
AFIAKRWNELKG

Sequences:

>Translated_892_residues
MMEQPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAEK
LGEYKQNRKDAPKEMLLQIPIALEWLQKMGFVCVEVNGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKT
EFLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYRALIHDKA
SAFLSKELATLERGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILDNAPLLDNTPALDNTPKKSC
MIVLESAAPLSAFLEKLEKTNARVFARLVLDKEKKVLALAFLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIG
HDLKPLLSFLKAKYQVPLENIRIQDTQILAFLKNPEKVGFDEVLKEYLKEELIPHEKIKDFKTKAEKLELLSVELNALKR
LCEYFEKGGLEENLLSLAREIETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKNELHVLERQILELIGVDFNLNSPKQLSE
VLYDKLGLPKNKSHSTDEKSLLKILDKHPSIALILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSP
NLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFGEYLAKEKRSI
AKSINFGLVYGMGSKKLSETLNISLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDYVKG
NYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETS
AFIAKRWNELKG
>Mature_892_residues
MMEQPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAEK
LGEYKQNRKDAPKEMLLQIPIALEWLQKMGFVCVEVNGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKT
EFLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYRALIHDKA
SAFLSKELATLERGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLILDNAPLLDNTPALDNTPKKSC
MIVLESAAPLSAFLEKLEKTNARVFARLVLDKEKKVLALAFLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIG
HDLKPLLSFLKAKYQVPLENIRIQDTQILAFLKNPEKVGFDEVLKEYLKEELIPHEKIKDFKTKAEKLELLSVELNALKR
LCEYFEKGGLEENLLSLAREIETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKNELHVLERQILELIGVDFNLNSPKQLSE
VLYDKLGLPKNKSHSTDEKSLLKILDKHPSIALILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSP
NLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFGEYLAKEKRSI
AKSINFGLVYGMGSKKLSETLNISLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDYVKG
NYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETS
AFIAKRWNELKG

Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]

COG id: COG0749

COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 5'-3' exonuclease domain [H]

Homologues:

Organism=Homo sapiens, GI112420958, Length=450, Percent_Identity=30.2222222222222, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI139394648, Length=537, Percent_Identity=25.1396648044693, Blast_Score=153, Evalue=8e-37,
Organism=Escherichia coli, GI1790294, Length=945, Percent_Identity=32.3809523809524, Blast_Score=377, Evalue=1e-105,
Organism=Escherichia coli, GI226510970, Length=192, Percent_Identity=35.4166666666667, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI86563272, Length=441, Percent_Identity=30.3854875283447, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17933644, Length=441, Percent_Identity=31.5192743764172, Blast_Score=183, Evalue=4e-46,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR020046
- InterPro:   IPR020045
- InterPro:   IPR002421
- InterPro:   IPR020047
- InterPro:   IPR019760
- InterPro:   IPR001098
- InterPro:   IPR018320
- InterPro:   IPR002298
- InterPro:   IPR008918
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 102108; Mature: 102108

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00447 DNA_POLYMERASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEQPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
NMPFIVFALESQTKTKRAEKLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFVCVEVNGFE
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCC
ADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTEFLAKDCVEKYGILPSQFTD
HHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
YQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYRALIHDKA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
SAFLSKELATLERGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLIL
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEE
DNAPLLDNTPALDNTPKKSCMIVLESAAPLSAFLEKLEKTNARVFARLVLDKEKKVLALA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGHDLKPLLSFLKAKYQVPLEN
EEEECCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
IRIQDTQILAFLKNPEKVGFDEVLKEYLKEELIPHEKIKDFKTKAEKLELLSVELNALKR
CEECHHHHEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LCEYFEKGGLEENLLSLAREIETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKNELHVLER
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
QILELIGVDFNLNSPKQLSEVLYDKLGLPKNKSHSTDEKSLLKILDKHPSIALILEYREL
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHH
NKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSPKGLLIRKGFI
HHHHHHHCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
ASSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFGEYLAKEKRSI
CCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHH
AKSINFGLVYGMGSKKLSETLNISLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAF
HHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TLLGRYRVFDFTGANDYVKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLL
HHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEHH
QVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETSAFIAKRWNELKG
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMEQPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
NMPFIVFALESQTKTKRAEKLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFVCVEVNGFE
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCC
ADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTEFLAKDCVEKYGILPSQFTD
HHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
YQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYRALIHDKA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
SAFLSKELATLERGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPTPLIL
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEE
DNAPLLDNTPALDNTPKKSCMIVLESAAPLSAFLEKLEKTNARVFARLVLDKEKKVLALA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FLYEDQGYFLPLEEALFSPFSLEFLQNAFFKMLQHAQIIGHDLKPLLSFLKAKYQVPLEN
EEEECCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
IRIQDTQILAFLKNPEKVGFDEVLKEYLKEELIPHEKIKDFKTKAEKLELLSVELNALKR
CEECHHHHEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LCEYFEKGGLEENLLSLAREIETPFMKVLMGMEFQGFKIDAPYFKRLEQEFKNELHVLER
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
QILELIGVDFNLNSPKQLSEVLYDKLGLPKNKSHSTDEKSLLKILDKHPSIALILEYREL
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHH
NKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSPKGLLIRKGFI
HHHHHHHCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCC
ASSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFGEYLAKEKRSI
CCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHH
AKSINFGLVYGMGSKKLSETLNISLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAF
HHHCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TLLGRYRVFDFTGANDYVKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLL
HHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEHH
QVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETSAFIAKRWNELKG
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]