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The map label for this gene is aroE

Identifier: 15645863

GI number: 15645863

Start: 1324695

End: 1325486

Strand: Reverse

Name: aroE

Synonym: HP1249

Alternate gene names: 15645863

Gene position: 1325486-1324695 (Counterclockwise)

Preceding gene: 15645864

Following gene: 15645862

Centisome position: 79.47

GC content: 39.14

Gene sequence:

>792_bases
ATGAAATTAAAATCTTTTGGGGTTTTTGGAAATCCCATTAAGCATTCCAAATCGCCCTTAATCCATAACGCTTGTTTTTT
AACTTTTCAAAAAGAATTAAGGTTTTTGGGGCATTACCACCCCATATTACTCCCTTTAGAAAGCCACATCAAAAGCGAGT
TTTTGCATTTGGGATTGAGTGGGGCTAATGTAACCTTACCCTTTAAAGAAAGGGCGTTTCAAGTTTGCGATAAAATCAAA
GGTATCGCGCTTGAATGCGGAGCGGTCAATACGCTTGTTTTAGAAAATGATGAGCTTGTGGGTTACAATACCGACGCTTT
AGGGTTTTATCTTTCTTTAAAGCAAAAAAACTATCAAAACGCTTTGATTTTAGGAGCTGGGGGGAGCGCTAAAGCCCTAG
CGTGTGAATTGAAAAAACAAGGCTTACAAGTGAGCGTGTTGAACCGCTCTTCTAGGGGATTGGATTTTTTCCAACGCCTG
GGCTGTGATTGTTTTATGGAGCCTCCTAAAAGCGCTTTTGATTTGATTATTAACGCCACTTCAGCGAGTTTGCATAACGA
ATTGCCTTTGAATAAAGAGGTTTTGAAAGGGTATTTTAAAGAGGGCAAGCTCGCTTATGATTTGGCGTATGGGTTTTTAA
CGCCCTTTTTGTCTTTAGCCAAAGAGTTAAAAACCCCTTTTCAAGACGGAAAAGACATGCTCATCTATCAAGCTGCTTTA
AGTTTTGAAAAATTCAGCGCTTCTCAAATCCCTTATTCAAAAGCGTTTGAAGTCATGCGAAGTGTTTTTTGA

Upstream 100 bases:

>100_bases
GTTTTAGAAATCCAAAACGATTGGGCTGAAATTGAATTTTCTCACGAAACAAAGGGCTATGTGTTTTTAAAACTTTTAAA
AAAGGCTGAATGAAAGAATA

Downstream 100 bases:

>100_bases
TGCAAGGGTTTTTAAGAAGCCTGTTTTTTGGGGTTAAAAAGATCCCTAAACCATTCGCTCCTCTAGTAGAAAAGGGCGTT
TTAAAAGAAGCGCTTGAATT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIK
GIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRL
GCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAAL
SFEKFSASQIPYSKAFEVMRSVF

Sequences:

>Translated_263_residues
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIK
GIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRL
GCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAAL
SFEKFSASQIPYSKAFEVMRSVF
>Mature_263_residues
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIK
GIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRL
GCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAAL
SFEKFSASQIPYSKAFEVMRSVF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=259, Percent_Identity=34.7490347490347, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1787983, Length=290, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320332, Length=292, Percent_Identity=25.6849315068493, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29273; Mature: 29273

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCC
GANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQN
CCEEEECHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEEECCCCCEEEEEEEECCCCCC
ALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINAT
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCCEECCCCCHHHHEEEECC
SASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAAL
HHHHHCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHCCCCCEEEHHHHH
SFEKFSASQIPYSKAFEVMRSVF
HHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCC
GANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQN
CCEEEECHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEEECCCCCEEEEEEEECCCCCC
ALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINAT
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCCEECCCCCHHHHEEEECC
SASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAAL
HHHHHCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHCCCCCEEEHHHHH
SFEKFSASQIPYSKAFEVMRSVF
HHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]