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Identifier: 15645621

GI number: 15645621

Start: 1068021

End: 1068554

Strand: Reverse

Name: Not Available

Synonym: HP1006

Alternate gene names: 15645621

Gene position: 1068554-1068021 (Counterclockwise)

Preceding gene: 15645623

Following gene: 15645619

Centisome position: 64.07

GC content: 35.21

Gene sequence:

>534_bases
GTGGTTTCACTGAAAGAGAGTAAGAAATTTGAAGAAAGGGTTTATCTTTTTTTAGATGAATTTGTGCGTTTTGGTAAATT
GCCTTTTTTATTAGAAATGCCAGCATTAAGTAGGAGCTATGGTGTGGTTTTAATTTTTATCACGCAATCCAACGCTCTTA
TTGAAAAATATTACGGCAGAGAAGATGCAAGAATTGTTAATAGCACCGTGGCTTACAAAATAATTTTCAAAATGGATGAT
TTAGAATACGCTAAACAGGTGAGCGAAGAAGTCGGTAAGATGACTAGAAAAACACGAAGCCACTCTACAGAAAAAGGACA
ACTCATTACCGGAGGGACTTCTAGTATAGGTAAAGAGGCGTGGGACTTATTGAGCGCGCAAGATATTATGAATATTGATA
AAGATGAAGTGATCGTTTTAGTAAGCGGTCATAAGGCTAAACCCTTAAAATTAAAAGCGAATTATTATTTCAAAAACAAA
GAATTACTCTCTCGTATTAACTGGGAAGTCAAGCCCAATGAAGAAGTGTTTTGA

Upstream 100 bases:

>100_bases
TTGGGGTAGGAAATATCCATGCAGACTTTAAAGAACAAAGCCTTTCGTGTTAGCGTTCAATAGAATGCTTTAGTTAGGAA
GCTCCTTGCTTTAGCAAGGG

Downstream 100 bases:

>100_bases
TGGATTAAAAAAGTTTGCATGAGTATTTTTTAATTGCTTTTTTAAAAATCGCTTTCTACAACTCCTTATCCTTGTTGCTA
AAAAAAGAATGCGCCAATTT

Product: conjugal transfer protein (traG)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MVSLKESKKFEERVYLFLDEFVRFGKLPFLLEMPALSRSYGVVLIFITQSNALIEKYYGREDARIVNSTVAYKIIFKMDD
LEYAKQVSEEVGKMTRKTRSHSTEKGQLITGGTSSIGKEAWDLLSAQDIMNIDKDEVIVLVSGHKAKPLKLKANYYFKNK
ELLSRINWEVKPNEEVF

Sequences:

>Translated_177_residues
MVSLKESKKFEERVYLFLDEFVRFGKLPFLLEMPALSRSYGVVLIFITQSNALIEKYYGREDARIVNSTVAYKIIFKMDD
LEYAKQVSEEVGKMTRKTRSHSTEKGQLITGGTSSIGKEAWDLLSAQDIMNIDKDEVIVLVSGHKAKPLKLKANYYFKNK
ELLSRINWEVKPNEEVF
>Mature_177_residues
MVSLKESKKFEERVYLFLDEFVRFGKLPFLLEMPALSRSYGVVLIFITQSNALIEKYYGREDARIVNSTVAYKIIFKMDD
LEYAKQVSEEVGKMTRKTRSHSTEKGQLITGGTSSIGKEAWDLLSAQDIMNIDKDEVIVLVSGHKAKPLKLKANYYFKNK
ELLSRINWEVKPNEEVF

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG3505

COG function: function code U; Type IV secretory pathway, VirD4 components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the virD4/traG family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014135
- InterPro:   IPR003688 [H]

Pfam domain/function: PF02534 TraG [H]

EC number: NA

Molecular weight: Translated: 20442; Mature: 20442

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLKESKKFEERVYLFLDEFVRFGKLPFLLEMPALSRSYGVVLIFITQSNALIEKYYGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCHHHHHHCCC
EDARIVNSTVAYKIIFKMDDLEYAKQVSEEVGKMTRKTRSHSTEKGQLITGGTSSIGKEA
CCHHHHHHHEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
WDLLSAQDIMNIDKDEVIVLVSGHKAKPLKLKANYYFKNKELLSRINWEVKPNEEVF
HHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVSLKESKKFEERVYLFLDEFVRFGKLPFLLEMPALSRSYGVVLIFITQSNALIEKYYGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCHHHHHHCCC
EDARIVNSTVAYKIIFKMDDLEYAKQVSEEVGKMTRKTRSHSTEKGQLITGGTSSIGKEA
CCHHHHHHHEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
WDLLSAQDIMNIDKDEVIVLVSGHKAKPLKLKANYYFKNKELLSRINWEVKPNEEVF
HHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA