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Identifier: 15645478

GI number: 15645478

Start: 912291

End: 913283

Strand: Reverse

Name: Not Available

Synonym: HP0859

Alternate gene names: 15645478

Gene position: 913283-912291 (Counterclockwise)

Preceding gene: 15645479

Following gene: 15645477

Centisome position: 54.76

GC content: 39.07

Gene sequence:

>993_bases
ATGCGTTATATTGATGATGAATTAGAAAATCAAACGATTTTAATCACCGGTGGGGCTGGCTTTGTAGGCAGTAATCTAGC
CTTTTATTTTCAAGAGAACCACCCTAAAGCTAAAGTAATCATTTTAGATAAATTCCGCAGTAACACGCTTTTCAGTAATA
AGCGCCCCAGTTCTTTAGGGCATTTTAAGAATTTAATCGGTTTTAAGGGTGAGGTGATTGCAGCTGATATTAATAACCCC
TTAGATTTAAGGCGTTTAGAAAAATTGCATTTTGATTATTTGTTCCACCAAGCCGCTGTCTCTGATACGACCATGCTGGA
TCAAGAATTAGTGATGAAGACCAATTATCAGGCTTTTTTAAACCTTTTAGAAATCGCTCGCTCAAAAAAAGCTAAAGTGA
TTTACGCTTCTTCAGCGGGCGTTTATGGCAACACCAAAGCCCCCAATGTGGTAGGCTCAAACGAAAGCCCTGAAAATGTT
TATGGCTTTTCCAAGCTTTGCATGGATGAATTTGTCCTCTCCCATTCAAACGACAATGTTCAAGTGGGCTTAAGGTATTT
TAATGTCTATGGGCCTAGGGAATTTTATAAAGAAAAAACCGCCTCTATGGTTTTGCAACTCGCCTTAGGCGCGATGGCGT
TTAAGGAAGTCAAGCTTTTTGAATTTGGCGAGCAATTAAGGGATTTTGTCTATATTGAAGATGTGATCCAAGCGAGCGTG
AAAGCGATGAAGGCTCAAAAAAGCGGGGTTTATAATGTGGGTTATTCCCAAGCCAGAAGTTATAATGAAATCGTTAGCAT
TTTAAAAGAGCATTTAGGGGATTTTAAAGTGAGTTATATCAAAAACCCTTATGCTTTCTTCCAAAAGCACACCCAAGCAC
ACATTGAGCCTGCTATTTTGGATTTGGATTACACCCCTTTATACGATTTGGAAAGCGGCATTAAAGATTATTTGCCCCAT
ATCCATGCGATTTTTAAAGGACAGTGCGCATGA

Upstream 100 bases:

>100_bases
ATAACCTTTTGCTCATTCAAAACCCTTTAAAAACTCCTCATTCTTGGATACAATGTAAAGATTTTAAAGAGATGATAGAT
CTAATCAAATAAGGACAAGA

Downstream 100 bases:

>100_bases
AAAAAATCTTAGTCATAGGCGATCTGATCGCTGATTATTATTTGTGGGGGAAGAGCGAACGGCTTTCGCCTGAAGCCCCT
GTGCCTGTTTTAGAAGTCCA

Product: ADP-L-glycero-D-mannoheptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLGHFKNLIGFKGEVIAADINNP
LDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGSNESPENV
YGFSKLCMDEFVLSHSNDNVQVGLRYFNVYGPREFYKEKTASMVLQLALGAMAFKEVKLFEFGEQLRDFVYIEDVIQASV
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIKDYLPH
IHAIFKGQCA

Sequences:

>Translated_330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLGHFKNLIGFKGEVIAADINNP
LDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGSNESPENV
YGFSKLCMDEFVLSHSNDNVQVGLRYFNVYGPREFYKEKTASMVLQLALGAMAFKEVKLFEFGEQLRDFVYIEDVIQASV
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIKDYLPH
IHAIFKGQCA
>Mature_330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLGHFKNLIGFKGEVIAADINNP
LDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGSNESPENV
YGFSKLCMDEFVLSHSNDNVQVGLRYFNVYGPREFYKEKTASMVLQLALGAMAFKEVKLFEFGEQLRDFVYIEDVIQASV
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIKDYLPH
IHAIFKGQCA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=324, Percent_Identity=26.2345679012346, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1790049, Length=321, Percent_Identity=29.9065420560748, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539532, Length=287, Percent_Identity=26.8292682926829, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=24.1590214067278, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17568069, Length=261, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=28.8819875776398, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37413; Mature: 37413

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHH
HFKNLIGFKGEVIAADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
NLLEIARSKKAKVIYASSAGVYGNTKAPNVVGSNESPENVYGFSKLCMDEFVLSHSNDNV
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
QVGLRYFNVYGPREFYKEKTASMVLQLALGAMAFKEVKLFEFGEQLRDFVYIEDVIQASV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAIL
HHHHHHHCCCEECCHHHHCCHHHHHHHHHHHHCCEEEEHHCCHHHHHHHHHHHCCCEEEE
DLDYTPLYDLESGIKDYLPHIHAIFKGQCA
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRYIDDELENQTILITGGAGFVGSNLAFYFQENHPKAKVIILDKFRSNTLFSNKRPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHH
HFKNLIGFKGEVIAADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
NLLEIARSKKAKVIYASSAGVYGNTKAPNVVGSNESPENVYGFSKLCMDEFVLSHSNDNV
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
QVGLRYFNVYGPREFYKEKTASMVLQLALGAMAFKEVKLFEFGEQLRDFVYIEDVIQASV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAIL
HHHHHHHCCCEECCHHHHCCHHHHHHHHHHHHCCEEEEHHCCHHHHHHHHHHHCCCEEEE
DLDYTPLYDLESGIKDYLPHIHAIFKGQCA
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA