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Identifier: 15645477

GI number: 15645477

Start: 910909

End: 912294

Strand: Reverse

Name: Not Available

Synonym: HP0858

Alternate gene names: 15645477

Gene position: 912294-910909 (Counterclockwise)

Preceding gene: 15645478

Following gene: 15645476

Centisome position: 54.7

GC content: 41.49

Gene sequence:

>1386_bases
ATGAAAAAAATCTTAGTCATAGGCGATCTGATCGCTGATTATTATTTGTGGGGGAAGAGCGAACGGCTTTCGCCTGAAGC
CCCTGTGCCTGTTTTAGAAGTCCAGAGGGAGAGTAAGAATTTAGGCGGAGCGGCTAATGTGGCTAATAACCTCATTTCTT
TAAAAGCTAAAGTTTTTTTATGTGGGGTCGTGGGCGATGATTTAGAGGGCGAGCATTTCATTAGCGCTTTAAAAGCAAGA
GGGATTGACGCTTCAGGTATTTTGATAGATAAAACCCGTTGCACCACGCTTAAAACGCGCATCATCGCGCAAAACCAGCA
AATCGCGCGCGTGGATAAGGAAATCAAAGACCCCTTAAACGCTGATTTAAGAAAAAAACTTTTAGATTTTTTCACAGAAA
AAATCCAAGAAATAGATGGCGTTATCCTTTCAGATTACAATAAGGGCGTGTTGGATTTTGAACTCACTCAAGCAATGATC
GCTCTAGCCAACCAACACCACAAGCTCATTTTATGCGACCCTAAAGGGAAAGATTATAGCAAATATTCCCATGCGAGTTT
GATCACGCCTAATCGCACCGAATTAGAGCATGCGCTCCATTTGAAATTAGACAGCCATGCGAATTTATCAAAAGCGCTCC
AAATCTTAAAAGAAACTTATCATATCGCTATGCCTTTAGTAACTTTGAGTGAACAAGGCATCGCTTTTTTAGAAAAAGGC
GAGTTAGTCAATTGCCCCACTATCGCTAAAGAAGTTTATGATGTAACTGGGGCAGGCGATACGGTGATCGCGTCTTTAAC
GCTCTCTTTATTAGAATCAATGAGCCTAAAAGATGCTTGCGAGTTTGCCAATGCGGCGGCGGCTGTGGTGGTGGGTAAAA
TGGGGAGCGCGTTAGCGAGTTTAGAAGAAATCGCTTTGATTTTGAACCAAACGCACCCTAAAATCCTTTCTTTAGAAAAG
CTGTTAGAAACTTTAGATCAGCAAAAAATCATTTTCACCAATGGCTGTTTTGACCTCCTCCATAAAGGGCATGCGAGCTA
TTTGCAAAAGGCTAAAGCTTTAGGGGATATTCTCATTGTGGGGTTAAATAGCGACGCTTCCATCAAAAGGCTTAAGGGGG
ATAAACGCCCCATAGTGAGCGAAAAAGACAGAGCGTTTCTTTTAGCGAGTTTGTCTTGCGTGGATTATGTCGTGGTGTTT
GAAGAAGACACGCCAATCAAATTAATTCAAGCCCTAAAGCCTGATATTTTAGTCAAGGGAGCGGATTATCTTAATAAAGA
AGTCATAGGGAGCGAGTTTGCTAAAGAAACCCATTTGATGGAGTTTGAAGAAGGTTATTCCACAAGTGCTATCATAGAAA
AAATTAAAAGGACATGCAATGATTGA

Upstream 100 bases:

>100_bases
CTGCTATTTTGGATTTGGATTACACCCCTTTATACGATTTGGAAAGCGGCATTAAAGATTATTTGCCCCATATCCATGCG
ATTTTTAAAGGACAGTGCGC

Downstream 100 bases:

>100_bases
TAATTTAATTAAAAAAGAATTTTTAGCCCATAAGGAAGCGTTAGAAAAAAGTTTAGAGGGTTTGCAAGAAGCGTTAAAAC
AAAGCGTTCATCTTTTGATA

Product: ADP-heptose synthase (rfaE)

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFISALKAR
GIDASGILIDKTRCTTLKTRIIAQNQQIARVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQAMI
ALANQHHKLILCDPKGKDYSKYSHASLITPNRTELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILSLEK
LLETLDQQKIIFTNGCFDLLHKGHASYLQKAKALGDILIVGLNSDASIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVF
EEDTPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTCND

Sequences:

>Translated_461_residues
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFISALKAR
GIDASGILIDKTRCTTLKTRIIAQNQQIARVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQAMI
ALANQHHKLILCDPKGKDYSKYSHASLITPNRTELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILSLEK
LLETLDQQKIIFTNGCFDLLHKGHASYLQKAKALGDILIVGLNSDASIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVF
EEDTPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTCND
>Mature_461_residues
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGEHFISALKAR
GIDASGILIDKTRCTTLKTRIIAQNQQIARVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQAMI
ALANQHHKLILCDPKGKDYSKYSHASLITPNRTELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILSLEK
LLETLDQQKIIFTNGCFDLLHKGHASYLQKAKALGDILIVGLNSDASIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVF
EEDTPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTCND

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=471, Percent_Identity=40.552016985138, Blast_Score=320, Evalue=1e-88,
Organism=Drosophila melanogaster, GI45550975, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45550974, Length=199, Percent_Identity=26.6331658291457, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 50689; Mature: 50689

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFL
CCEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHEEEEEE
CGVVGDDLEGEHFISALKARGIDASGILIDKTRCTTLKTRIIAQNQQIARVDKEIKDPLN
EEECCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCC
ADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQAMIALANQHHKLILCDPKGKDYS
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCC
KYSHASLITPNRTELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
CCCCCEECCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEECC
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALAS
CEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIALILNQTHPKILSLEKLLETLDQQKIIFTNGCFDLLHKGHASYLQKAKALGDILIV
HHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEEEE
GLNSDASIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFEEDTPIKLIQALKPDILVKG
EECCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHEEEEEEECCCCCHHHHHHCCCCEEEEC
ADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTCND
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVQRESKNLGGAANVANNLISLKAKVFL
CCEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHEEEEEE
CGVVGDDLEGEHFISALKARGIDASGILIDKTRCTTLKTRIIAQNQQIARVDKEIKDPLN
EEECCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCC
ADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQAMIALANQHHKLILCDPKGKDYS
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCC
KYSHASLITPNRTELEHALHLKLDSHANLSKALQILKETYHIAMPLVTLSEQGIAFLEKG
CCCCCEECCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEECC
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALAS
CEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIALILNQTHPKILSLEKLLETLDQQKIIFTNGCFDLLHKGHASYLQKAKALGDILIV
HHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEEEE
GLNSDASIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFEEDTPIKLIQALKPDILVKG
EECCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHEEEEEEECCCCCHHHHHHCCCCEEEEC
ADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTCND
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA