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The map label for this gene is glmU

Identifier: 15645307

GI number: 15645307

Start: 732667

End: 733968

Strand: Reverse

Name: glmU

Synonym: HP0683

Alternate gene names: 15645307

Gene position: 733968-732667 (Counterclockwise)

Preceding gene: 15645309

Following gene: 15645306

Centisome position: 44.01

GC content: 41.78

Gene sequence:

>1302_bases
ATGCTTTCTGTCATCATACTGGCCGCTGGTAAAGGCACTCGCATGCGTTCTAGCCTGCCTAAAACTTTACACACCATTTG
TGGGGAGCCTATGTTGTTTTACATTTTAGAAACGGCTTTTTCAATCAGCGATGATGTGCATCTTATCTTACACCACCAAC
AAGAACGCATTAAAGAAGCGGTGTTGGAGCGTTTTAAGGGCGTCATTTTTCACACTCAAATTGTGGAAAAATATTCAGGG
ACAGGTGGGGCTATCATGCAAAAAGATAAAACGCCTATTTCTACGAAACATGAGCGGGTTTTGATTTTGAATGCGGACAT
GCCTTTAATCACTAAAGACGCTCTCGCCCCCTTATTAGAAAGCAAGAATAACGCTATAGGCTTACTCCATTTAGCTGACC
CTAAAGGTTATGGGCGCGTTGTTTTAGAAAACCATCAGGTTAAAAAGATTGTAGAAGAAAAGGACGCTAATGATGAAGAA
AAAGAAATTAAAAGCGTGAATGCTGGCGTGTATGGGTTTGAAAGGGATTTTTTAGAAAAATACTTACCCAAGCTCCATGA
CCAAAACGCCCAAAAAGAATACTACCTCACGGATTTAATCGCTCTAGGGATCAATGAAAACGAAACAATTGACGCTATTT
TCTTAAAAGAAGAGTGTTTTTTAGGGGTGAATAGCCAAACAGAAAGGGCGAAAGCTGAAGAAATCATGCTAGAAAGACTG
CGCAAAAACGCCATGGACTTGGGGGTAGTGATGCAATTGCCTAATAGCATTTATTTAGAAAAAGGCGTGAGTTTTAAGGG
GGAGTGCGTTTTAGAGCAAGGGGTGCGTTTGATTGGGAATTGTTTGATAGAAAACGCGCATATTAAGGCTTATAGCGTGA
TAGAAGAGAGCCAGATTGTTAATAGCAGTGTGGGGCCGTTTGCCCATGCGCGCCCTAAAAGCGTGATTTGTAATAGCCAT
GTGGGGAATTTTGTAGAGACTAAAAACGCTAAACTTCAAGGCACTAAAGCAGGGCATTTGAGCTATTTAGGGGATTGTGA
GATAGGGAAAAACACAAATGTAGGGGCTGGCGTGATCACTTGCAATTACGATGGTAAAAAGAAACACCAAACAATCATCG
GTGAAAATGTCTTTATAGGGAGCGATAGCCAGCTAGTCGCCCCCATAAATATCGGCTCTAATGTCTTAATCGGCAGCGGC
ACCACTATCACTAAAGACATTCCTAGCGGTTCGTTGAGCCTTTCACGCGCCCCTCAAACCAACATTGAAAACGGGTATTT
TAAGTTTTTTAAGAAACCTTAA

Upstream 100 bases:

>100_bases
TGAAAAAACGCAAAATTCTAGCCTTAAATCTTTGATGAAACGAAGTCAAATTATAAGATAAGGCATGTTAAAATTCCCTA
AAATGAGTTTAAGGATTTTA

Downstream 100 bases:

>100_bases
TTTGTTTGAATAATGAAAAATCCTAAAATATTAATCATTTACTTTAATCATTTAATTTGTGTAAAAACAAAACACTTATT
GAGTTTTTTGTGATCTTTTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLSVIILAAGKGTRMRSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLERFKGVIFHTQIVEKYSG
TGGAIMQKDKTPISTKHERVLILNADMPLITKDALAPLLESKNNAIGLLHLADPKGYGRVVLENHQVKKIVEEKDANDEE
KEIKSVNAGVYGFERDFLEKYLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLKEECFLGVNSQTERAKAEEIMLERL
RKNAMDLGVVMQLPNSIYLEKGVSFKGECVLEQGVRLIGNCLIENAHIKAYSVIEESQIVNSSVGPFAHARPKSVICNSH
VGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSG
TTITKDIPSGSLSLSRAPQTNIENGYFKFFKKP

Sequences:

>Translated_433_residues
MLSVIILAAGKGTRMRSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLERFKGVIFHTQIVEKYSG
TGGAIMQKDKTPISTKHERVLILNADMPLITKDALAPLLESKNNAIGLLHLADPKGYGRVVLENHQVKKIVEEKDANDEE
KEIKSVNAGVYGFERDFLEKYLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLKEECFLGVNSQTERAKAEEIMLERL
RKNAMDLGVVMQLPNSIYLEKGVSFKGECVLEQGVRLIGNCLIENAHIKAYSVIEESQIVNSSVGPFAHARPKSVICNSH
VGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSG
TTITKDIPSGSLSLSRAPQTNIENGYFKFFKKP
>Mature_433_residues
MLSVIILAAGKGTRMRSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLERFKGVIFHTQIVEKYSG
TGGAIMQKDKTPISTKHERVLILNADMPLITKDALAPLLESKNNAIGLLHLADPKGYGRVVLENHQVKKIVEEKDANDEE
KEIKSVNAGVYGFERDFLEKYLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLKEECFLGVNSQTERAKAEEIMLERL
RKNAMDLGVVMQLPNSIYLEKGVSFKGECVLEQGVRLIGNCLIENAHIKAYSVIEESQIVNSSVGPFAHARPKSVICNSH
VGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSG
TTITKDIPSGSLSLSRAPQTNIENGYFKFFKKP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=457, Percent_Identity=38.5120350109409, Blast_Score=305, Evalue=4e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 47804; Mature: 47804

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVIILAAGKGTRMRSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEA
CEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHH
VLERFKGVIFHTQIVEKYSGTGGAIMQKDKTPISTKHERVLILNADMPLITKDALAPLLE
HHHHHHCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHH
SKNNAIGLLHLADPKGYGRVVLENHQVKKIVEEKDANDEEKEIKSVNAGVYGFERDFLEK
CCCCEEEEEEEECCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHH
YLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLKEECFLGVNSQTERAKAEEIMLERL
HHHHHCCCCCCCHHEEEEEEEECCCCCCCEEEEEEECHHEECCCCCHHHHHHHHHHHHHH
RKNAMDLGVVMQLPNSIYLEKGVSFKGECVLEQGVRLIGNCLIENAHIKAYSVIEESQIV
HHHHHCCHHEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
NSSVGPFAHARPKSVICNSHVGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVIT
CCCCCCCCCCCCCCEEECCCCCCCEECCCCEEECCCCCCCEEEECCCCCCCCCCCCEEEE
CNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSLSRAPQT
ECCCCCCHHHEEECCEEEECCCCCEEEEEECCCEEEEECCCEEEECCCCCCCEECCCCCC
NIENGYFKFFKKP
CCCCCEEEEECCC
>Mature Secondary Structure
MLSVIILAAGKGTRMRSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEA
CEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHH
VLERFKGVIFHTQIVEKYSGTGGAIMQKDKTPISTKHERVLILNADMPLITKDALAPLLE
HHHHHHCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHH
SKNNAIGLLHLADPKGYGRVVLENHQVKKIVEEKDANDEEKEIKSVNAGVYGFERDFLEK
CCCCEEEEEEEECCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHH
YLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLKEECFLGVNSQTERAKAEEIMLERL
HHHHHCCCCCCCHHEEEEEEEECCCCCCCEEEEEEECHHEECCCCCHHHHHHHHHHHHHH
RKNAMDLGVVMQLPNSIYLEKGVSFKGECVLEQGVRLIGNCLIENAHIKAYSVIEESQIV
HHHHHCCHHEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
NSSVGPFAHARPKSVICNSHVGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVIT
CCCCCCCCCCCCCCEEECCCCCCCEECCCCEEECCCCCCCEEEECCCCCCCCCCCCEEEE
CNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSLSRAPQT
ECCCCCCHHHEEECCEEEECCCCCEEEEEECCCEEEEECCCEEEECCCCCCCEECCCCCC
NIENGYFKFFKKP
CCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA