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Identifier: 15645010

GI number: 15645010

Start: 392364

End: 393587

Strand: Reverse

Name: Not Available

Synonym: HP0382

Alternate gene names: 15645010

Gene position: 393587-392364 (Counterclockwise)

Preceding gene: 15645012

Following gene: 15645009

Centisome position: 23.6

GC content: 38.89

Gene sequence:

>1224_bases
ATGCTTGACATATGGATAGATATGATAATTTGTATTTTTTATTTGCTCTTTTTTACGACTCCTTACATTGTAGGCGATAT
TTTGCAATTGAAATTTATCCGCCAAAAGCTCTGCGAAAAACCTGTTTTACTCCCACAAAAGGATTATGAAGAAGCGGGAA
ATTATGCCATTAGGAAAATGCAATTATCCATTATTTCTCAAATTTTAGACGGGATAATCTTTGCTGGGTGGGTCTTTTTT
GGTTTGACGCATTTAGAAGATCTCACGCATTATTTAAACCTTCCTGAAACGCTAGGTTACTTGGTGTTTGCCTTGTTGTT
TTTAGCGATTCAAAGCGTTTTAGCTTTACCCATTAGCTACTACACCACGATGCATTTGGATAAGGAATTTGGCTTTTCTA
AGGTGAGCTTGTCGTTGTTTTTTAAGGATTTTTTCAAAGGGTTATCGCTCACTTTAAGCGTGGGGTTGTTGTTGATTTAC
ACTCTCATTATGATCATTGAACATGTGGAACATTGGGAGATTAGCTCGTTTTTTGTCGTGTTTGTTTTTATGATCTTGGC
TAATCTTTTTTACCCTAAAATCGCTCAGCTTTTCAACCAATTCACCCCCTTGAACAATAGGGATTTAGAGAGTCAAATTG
AGGGCATGATGGATAAGGTGGGTTTTAAATCTGAAGGTATCTTTGTGATGGACGCTAGCAAGAGGGACGGGCGTTTGAAC
GCGTATTTTGGAGGCTTGGGTAAAAACAAGCGGGTGGTGTTGTTTGACACTTTGATCTCTAAAGTTGGGACAGAAGGGCT
TTTAGCCATTTTAGGGCATGAATTAGGGCATTTTAAAAATAAGGATTTGTTGAAAAGTTTAGGGATTATGGGAGGCTTAC
TCGCTCTTGTTTTTGCTCTGATCGCTCATTTGCCGCCGTTGGTTTTTGAAGGCTTCAATGTCTCACAAACGCCAGCGAGT
TTGATTGCGATTTTACTCTTGTTTTTGCCGGTATTTTCTTTTTACGCTATGCCTTTGATCGGGTTTTTTAGCCGAAAGAA
TGAATACAATGCAGACAAGTTTGGGGCGAGTTTAAGCTCTAAAGAGGTTTTAGCCAAAGCGTTAGTGTCTATTGTGAGTG
AGAATAAAGCGTTCCCCTATTCGCACCCTTTTTATGTTTTCTTGCATTTCACGCACCCGCCCTTATTAGAGCGCTTGAAA
GCTTTGGATTATGAAATTGAATGA

Upstream 100 bases:

>100_bases
CATATTTATTTAATTTTATGGTTTTATGGTAAATTTTTGAAAAATTGTTATAATTCCTACACTTTTATTGGTAAATTTAA
TGGAGAAAGGAGTTTGGAAT

Downstream 100 bases:

>100_bases
CCCTTTCGCAAGCCCTAAACAAAGCCAAAAAAGGATTATCGCAAAAAGGTTTTAGGGGGGGCTTAGAATCTGAAATTTTA
TTAGGCTTTGTCTTGCAAAA

Product: zinc-metallo protease (YJR117W)

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLDIWIDMIICIFYLLFFTTPYIVGDILQLKFIRQKLCEKPVLLPQKDYEEAGNYAIRKMQLSIISQILDGIIFAGWVFF
GLTHLEDLTHYLNLPETLGYLVFALLFLAIQSVLALPISYYTTMHLDKEFGFSKVSLSLFFKDFFKGLSLTLSVGLLLIY
TLIMIIEHVEHWEISSFFVVFVFMILANLFYPKIAQLFNQFTPLNNRDLESQIEGMMDKVGFKSEGIFVMDASKRDGRLN
AYFGGLGKNKRVVLFDTLISKVGTEGLLAILGHELGHFKNKDLLKSLGIMGGLLALVFALIAHLPPLVFEGFNVSQTPAS
LIAILLLFLPVFSFYAMPLIGFFSRKNEYNADKFGASLSSKEVLAKALVSIVSENKAFPYSHPFYVFLHFTHPPLLERLK
ALDYEIE

Sequences:

>Translated_407_residues
MLDIWIDMIICIFYLLFFTTPYIVGDILQLKFIRQKLCEKPVLLPQKDYEEAGNYAIRKMQLSIISQILDGIIFAGWVFF
GLTHLEDLTHYLNLPETLGYLVFALLFLAIQSVLALPISYYTTMHLDKEFGFSKVSLSLFFKDFFKGLSLTLSVGLLLIY
TLIMIIEHVEHWEISSFFVVFVFMILANLFYPKIAQLFNQFTPLNNRDLESQIEGMMDKVGFKSEGIFVMDASKRDGRLN
AYFGGLGKNKRVVLFDTLISKVGTEGLLAILGHELGHFKNKDLLKSLGIMGGLLALVFALIAHLPPLVFEGFNVSQTPAS
LIAILLLFLPVFSFYAMPLIGFFSRKNEYNADKFGASLSSKEVLAKALVSIVSENKAFPYSHPFYVFLHFTHPPLLERLK
ALDYEIE
>Mature_407_residues
MLDIWIDMIICIFYLLFFTTPYIVGDILQLKFIRQKLCEKPVLLPQKDYEEAGNYAIRKMQLSIISQILDGIIFAGWVFF
GLTHLEDLTHYLNLPETLGYLVFALLFLAIQSVLALPISYYTTMHLDKEFGFSKVSLSLFFKDFFKGLSLTLSVGLLLIY
TLIMIIEHVEHWEISSFFVVFVFMILANLFYPKIAQLFNQFTPLNNRDLESQIEGMMDKVGFKSEGIFVMDASKRDGRLN
AYFGGLGKNKRVVLFDTLISKVGTEGLLAILGHELGHFKNKDLLKSLGIMGGLLALVFALIAHLPPLVFEGFNVSQTPAS
LIAILLLFLPVFSFYAMPLIGFFSRKNEYNADKFGASLSSKEVLAKALVSIVSENKAFPYSHPFYVFLHFTHPPLLERLK
ALDYEIE

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=347, Percent_Identity=31.9884726224784, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17505484, Length=417, Percent_Identity=26.378896882494, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322577, Length=316, Percent_Identity=34.4936708860759, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI19922414, Length=335, Percent_Identity=31.044776119403, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24654305, Length=401, Percent_Identity=26.4339152119701, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI78707252, Length=399, Percent_Identity=25.31328320802, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707254, Length=399, Percent_Identity=25.31328320802, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46277; Mature: 46277

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]