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Identifier: 15645009

GI number: 15645009

Start: 391537

End: 392367

Strand: Reverse

Name: Not Available

Synonym: HP0381

Alternate gene names: 15645009

Gene position: 392367-391537 (Counterclockwise)

Preceding gene: 15645010

Following gene: 15645008

Centisome position: 23.53

GC content: 38.63

Gene sequence:

>831_bases
ATGACCCTTTCGCAAGCCCTAAACAAAGCCAAAAAAGGATTATCGCAAAAAGGTTTTAGGGGGGGCTTAGAATCTGAAAT
TTTATTAGGCTTTGTCTTGCAAAAAGAAAGGGTTTTTTTGCACACGCATGCCTATTTAGAGTTAAACCACGAAGAAGAGG
TGCGTTTTTTTGAATTGGTAGAAAAGCGCTTGAATAACTGCCCCATAGAGTATTTATTAGAAAGCTGTGATTTTTATGGG
CGCTCTTTTTTTGTGAATGAGCATGTTTTAATCCCACGACCTGAAACCGAGATTTTGGTCCAAAAAGCCCTTGATATTAT
TTCTCAATACCATTTAAAAGAGATAGGCGAAATCGGCATAGGGAGCGGATGCGTGTCTGTGAGTTTGGCTTTAGAAAACC
CTAATCTCTCTATTTATGCGAGCGATATTTCACCAAACGCTTTAGAAGTGGCGTCCAAAAATATTGAGCACTTTTGTCTA
AAAGAGCGTGTTTTTTTAAAACAAACACGCCTTTGGGATCATATGCCCATGATAGAAATGCTTGTCTCTAACCCGCCCTA
TATCGCTAGAAATTATCCTTTGGAAAAATCCGTCCTCAAAGAACCGCATGAAGCCCTTTTTGGGGGGGTTAAAGGCGATG
AGATCTTAAAAGAAATCGTTTTTTTAGCCGCTAAATTAAAAATCCCTTTTTTGGTTTGTGAAATGGGGTATGACCAGTTG
AAAAGCTTGAAAGAATGCTTGGAATTTTGCGGTTATGATGCAGAGTTTTACAAGGATTTGAGCGGCTTTGATAGAGGGTT
TGTGGGCGTTTTAAAAAGTTTTTTAAGATAA

Upstream 100 bases:

>100_bases
AGAATAAAGCGTTCCCCTATTCGCACCCTTTTTATGTTTTCTTGCATTTCACGCACCCGCCCTTATTAGAGCGCTTGAAA
GCTTTGGATTATGAAATTGA

Downstream 100 bases:

>100_bases
ATTAAAACTTAATTACCCTTTTAGTGTTACAATAAAAACACTTAAAACAATAAAGGATGCCGCTCATGTATGTTGAAAAA
ATTCTCCAGTCTTTACAGAA

Product: protoporphyrinogen oxidase (hemK)

Products: NA

Alternate protein names: M.AaoHemKP [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVRFFELVEKRLNNCPIEYLLESCDFYG
RSFFVNEHVLIPRPETEILVQKALDIISQYHLKEIGEIGIGSGCVSVSLALENPNLSIYASDISPNALEVASKNIEHFCL
KERVFLKQTRLWDHMPMIEMLVSNPPYIARNYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAKLKIPFLVCEMGYDQL
KSLKECLEFCGYDAEFYKDLSGFDRGFVGVLKSFLR

Sequences:

>Translated_276_residues
MTLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVRFFELVEKRLNNCPIEYLLESCDFYG
RSFFVNEHVLIPRPETEILVQKALDIISQYHLKEIGEIGIGSGCVSVSLALENPNLSIYASDISPNALEVASKNIEHFCL
KERVFLKQTRLWDHMPMIEMLVSNPPYIARNYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAKLKIPFLVCEMGYDQL
KSLKECLEFCGYDAEFYKDLSGFDRGFVGVLKSFLR
>Mature_275_residues
TLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVRFFELVEKRLNNCPIEYLLESCDFYGR
SFFVNEHVLIPRPETEILVQKALDIISQYHLKEIGEIGIGSGCVSVSLALENPNLSIYASDISPNALEVASKNIEHFCLK
ERVFLKQTRLWDHMPMIEMLVSNPPYIARNYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAKLKIPFLVCEMGYDQLK
SLKECLEFCGYDAEFYKDLSGFDRGFVGVLKSFLR

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=187, Percent_Identity=32.620320855615, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787463, Length=256, Percent_Identity=30.078125, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87082085, Length=197, Percent_Identity=32.994923857868, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31544; Mature: 31413

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVRFFELV
CCHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCEEEEEEEEEEEECCHHHHHHHHHH
EKRLNNCPIEYLLESCDFYGRSFFVNEHVLIPRPETEILVQKALDIISQYHLKEIGEIGI
HHHHCCCCHHHHHHHHHHCCCEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GSGCVSVSLALENPNLSIYASDISPNALEVASKNIEHFCLKERVFLKQTRLWDHMPMIEM
CCCCEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LVSNPPYIARNYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAKLKIPFLVCEMGYDQL
HHCCCCCEECCCCCCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHEECCCHHHH
KSLKECLEFCGYDAEFYKDLSGFDRGFVGVLKSFLR
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHC
>Mature Secondary Structure 
TLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAYLELNHEEEVRFFELV
CHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCEEEEEEEEEEEECCHHHHHHHHHH
EKRLNNCPIEYLLESCDFYGRSFFVNEHVLIPRPETEILVQKALDIISQYHLKEIGEIGI
HHHHCCCCHHHHHHHHHHCCCEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GSGCVSVSLALENPNLSIYASDISPNALEVASKNIEHFCLKERVFLKQTRLWDHMPMIEM
CCCCEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LVSNPPYIARNYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAKLKIPFLVCEMGYDQL
HHCCCCCEECCCCCCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHEECCCHHHH
KSLKECLEFCGYDAEFYKDLSGFDRGFVGVLKSFLR
HHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]