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Identifier: 15644728

GI number: 15644728

Start: 102461

End: 103921

Strand: Reverse

Name: Not Available

Synonym: HP0098

Alternate gene names: 15644728

Gene position: 103921-102461 (Counterclockwise)

Preceding gene: 15644732

Following gene: 15644727

Centisome position: 6.23

GC content: 40.52

Gene sequence:

>1461_bases
ATGCCTTTTGTCCCCACCCGTTCTTTGAAAGAAAAAAAGATTGATTTTATTGAAGCAATATTAAACCCCAACGCCCCAAA
AGGCGGGCTTTACACTTTAGAGCGTTTTGAAACATTACAATGGCAAGATTGTTTGAATCTGAGCTATAACGATCTAGTGG
AATGCGTGTTTGAGCGGTTGGGTTTAGAAATCCCTAAAAATTTACTGGCAAGCGCTTTAAAACGCTATGAAAATTTTGAT
AACCCTAAAAATCCAGCCCCTATTTTTGCGCTCAATGAAAGGCTTTTTGTCCAAGAACTCTACCATGGGCCTAGTTTGGC
GTTTAAAGACATGGCGTTGCAGCCTTTAGCGAGCTTGTTTTCTAATCTAGCGGTAGGAAAAAATGAAAAGTATTTAATGC
TCGTTTCCACGAGTGGTGATACCGGCCCTGCGACTTTAGAAAGTTTGGCAGGCATGCCTAATGTTTTTGTGGTGTGTTTA
TACCCCAAAGACGGCACAAGTTTGGTCCAAAAACTCCAAATGGTTACCCAAAGCGCTAGCAATTTAAAAGTCTTTGGGAT
CAGTGGGGATTTTGATGATGCGCAAAACGCGCTCAAAAACCTTTTAAAAGACGATGATTTTAACGAGGCTTTAAAAGCGT
GCCAATTGAAATTAAGCGTGGCTAATTCCGTGAATTTTGGGCGCATCGCTTTTCAAATCGTCTATCATATTTGGGGCTTT
TTGGAATTGTATAAAAAAGGCGCGATCAATTCTAAAGAAAAAATCACCCTAGCCATACCTAGCGGTAATTTTGGGAACGC
TTTAGGGGCGTTTTATGCCAAAAAAATGGGTTTGAATATTGATAAAATCAAGGTCGTAACCAACAGCAATGATGTTTTAA
GGGAGTTTATAGAGACAGGGCGTTACGATTTAACCCATCGTTCTTTAAAGCAAACTTACTCGCCGGCTATGGATATTTTA
AAAAGCTCTAATGTGGAAAGGGCGCTTTTTAGCCTTTTTGGGTTTGAACGCACGCTAGAATTGATGCAAGCTTTAGAAGA
AGAGAAATTTTATGCCTTAAAACCTAAAGAATTGGCCCTTTTACAGGAGCATTTTTCTTGCGCGAGCTGCTCAGATGAAG
CTTGTTTGAAAACGATCCAAGAAGTTTATGCAGAGCACCAATACCTGATTGACCCTCATACCGCCACCGCTTTAAACGCT
AGCTTGAAAACCCACGAAAAAACCCTTGTTTCCGCCACCGCCTCTTATGAGAAATTCCCTAGAATCACCCTTTTAGCCCT
AAACGAGCAAAAGAAAAACGATAACGATAAGGCCGCCCTAGAAACGCTTAAAAACAGCTACAATACCCCGGATAGCCAAC
GCCTTGATGATTTGTTTGAAAGAGGGATCAAGCACCAAGAAGTTTTAAAACTCAATGAGATCAAATCTTCTATTCTTTTG
TGGCTAGAAAGCCTACATTAA

Upstream 100 bases:

>100_bases
ACGATCAATCGTTCTCATTAAAAAACCATTTAAGGTTACATTCGCTCTTTTAGGGTATGCTACGACTTGAAATTATCCAA
AAATAAAAAGGAATCATTTT

Downstream 100 bases:

>100_bases
ATCTTTTTTAAGCCCTTATTCCTAATAAAATCTTAATTTTAAGTCAAACTACACTATAATAAGGAAATTCTAAACGAAAA
TTAAACTGAATGAAAGGAGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNDLVECVFERLGLEIPKNLLASALKRYENFD
NPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCL
YPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKACQLKLSVANSVNFGRIAFQIVYHIWGF
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL
KSSNVERALFSLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNA
SLKTHEKTLVSATASYEKFPRITLLALNEQKKNDNDKAALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
WLESLH

Sequences:

>Translated_486_residues
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNDLVECVFERLGLEIPKNLLASALKRYENFD
NPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCL
YPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKACQLKLSVANSVNFGRIAFQIVYHIWGF
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL
KSSNVERALFSLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNA
SLKTHEKTLVSATASYEKFPRITLLALNEQKKNDNDKAALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
WLESLH
>Mature_485_residues
PFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNDLVECVFERLGLEIPKNLLASALKRYENFDN
PKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLY
PKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKACQLKLSVANSVNFGRIAFQIVYHIWGFL
ELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDILK
SSNVERALFSLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNAS
LKTHEKTLVSATASYEKFPRITLLALNEQKKNDNDKAALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILLW
LESLH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=472, Percent_Identity=34.9576271186441, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI149193323, Length=445, Percent_Identity=31.4606741573034, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1786185, Length=324, Percent_Identity=30.2469135802469, Blast_Score=141, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319901, Length=432, Percent_Identity=33.1018518518519, Blast_Score=204, Evalue=3e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54707; Mature: 54576

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNDLVECVFERL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GLEIPKNLLASALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLF
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSAS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
NLKVFGISGDFDDAQNALKNLLKDDDFNEALKACQLKLSVANSVNFGRIAFQIVYHIWGF
CEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
RYDLTHRSLKQTYSPAMDILKSSNVERALFSLFGFERTLELMQALEEEKFYALKPKELAL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
LQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNASLKTHEKTLVSATASYEKFP
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RITLLALNEQKKNDNDKAALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
CEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WLESLH
HHHHCC
>Mature Secondary Structure 
PFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNDLVECVFERL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GLEIPKNLLASALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLF
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSAS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
NLKVFGISGDFDDAQNALKNLLKDDDFNEALKACQLKLSVANSVNFGRIAFQIVYHIWGF
CEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
RYDLTHRSLKQTYSPAMDILKSSNVERALFSLFGFERTLELMQALEEEKFYALKPKELAL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
LQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNASLKTHEKTLVSATASYEKFP
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RITLLALNEQKKNDNDKAALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
CEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WLESLH
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]