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The map label for this gene is gltA

Identifier: 15644659

GI number: 15644659

Start: 26078

End: 27358

Strand: Reverse

Name: gltA

Synonym: HP0026

Alternate gene names: 15644659

Gene position: 27358-26078 (Counterclockwise)

Preceding gene: 15644662

Following gene: 15644658

Centisome position: 1.64

GC content: 44.81

Gene sequence:

>1281_bases
ATGTCTGTCACTTTAGTCAATAATGAAAATAATGAACGCTATGAATTTGAAACGATTGAAAGCACTCGTGGGCCTAAAGC
GGTGGATTTTTCCAAGCTTTTTGAAACGACCGGGTTTTTTTCTTACGATCCAGGGTATTCTTCTACCGCTGGATGCCAAT
CTAAGATCAGCTATGTCAATGGCAAAAAAGGCGAATTGTATTACAGAGGGCATAGGATAGAAGATTTAGTCGCCAAATAC
AAATATGTAGATGTGTGCAAATTACTCCTCACAGGGGAATTACCCAAAAATCAAGATGAAAGCTTGGAATTTGAATTGGA
ATTGCGCCACAGGAGCTTTGTGCATGAGAGCTTACTCAACATGTTTTCAGCCTTCCCTAGCAACGCCCACCCTATGGCGA
AACTCTCTAGCGGAGTGTCTATCTTATCCACCCTTTATTCCACGCACCAAAACATGCACACTGAAGAAGATTACCAAACT
ATGGCCAGAAGGATTGTCGCTAAAATCCCCACGCTTGCGGCTATTTGCTATCGTAATGAAGTGGGAGCGCCTATCATTTA
TCCGGACATCGCACGCTCTTATGTGGAAAATATCCTTTTCATGCTGAGAGGGTATCCTTATAGTCGCTTAAAACACACCA
CTCAAGGCGAAGTGGAAATCACGCCCCTAGAAGTGGAAGCCTTTGATAAAATCCTAACCTTGCACGCTGATCACAGCCAA
AACGCCTCTTCTACCACGGTAAGGAATGTCGCTAGCACCGGCGTGCATCCTTATGCCGCCATTAGCGCGGGCATTAGCGC
TTTATGGGGGCATTTGCATGGCGGAGCGAATGAAAAAGTCCTTTTACAATTAGAAGAAATCGGCGATGTGAAAAATGTGG
ATAAATACATCGCGCGAGTGAAAGACAAAAACGACAATTTCAAACTCATGGGCTTTGGGCATAGGGTGTATAAAAGCTAC
GATCCGCGCGCTAAAATCTTAAAAGGCTTGAAAGACGAACTGCACCAAAAAGGCGTTAAAATGGACGAGAGGTTGAGCGA
AATCGCCGCGAAAGTGGAAGAAATCGCGCTAAAAGACGAGTATTTCATTGAAAGGAATCTCTACCCTAATGTGGATTTTT
ACTCCGGCACCATTTTAAGGGCTTTAAAAATCCCGGTGCGTTTTTTCACGCCGGTGTTTGTCATTGGCCGAACCGTAGGC
TGGTGCGCTCAGCTTTTAGAGCATGTCAAAAGCCCGCAAGCCAGGATCACACGCCCAAGACAAGTCTATGTAGGGGATTA
A

Upstream 100 bases:

>100_bases
TTGGAAATAACTTGAAAAAACGCAATGTTTTTAAAAGAAATCATTTAATTTTTTGGCTTATAATTAGGAGTTGAATGCTA
TCAAAACTTAAGGAAGTCAA

Downstream 100 bases:

>100_bases
GGCTTTGTCTTAACAGAGCGTTGAATAGAAGCGTTGGTTAAGCTTTAAGAAACGAATCAAAGCCTTGTTTAAAAGAATAA
GCGTCTCGCACCAAGCGAGC

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSVTLVNNENNERYEFETIESTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYVNGKKGELYYRGHRIEDLVAKY
KYVDVCKLLLTGELPKNQDESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQT
MARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHSQ
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSY
DPRAKILKGLKDELHQKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVG
WCAQLLEHVKSPQARITRPRQVYVGD

Sequences:

>Translated_426_residues
MSVTLVNNENNERYEFETIESTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYVNGKKGELYYRGHRIEDLVAKY
KYVDVCKLLLTGELPKNQDESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQT
MARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHSQ
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSY
DPRAKILKGLKDELHQKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVG
WCAQLLEHVKSPQARITRPRQVYVGD
>Mature_425_residues
SVTLVNNENNERYEFETIESTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYVNGKKGELYYRGHRIEDLVAKYK
YVDVCKLLLTGELPKNQDESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTM
ARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHSQN
ASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSYD
PRAKILKGLKDELHQKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGW
CAQLLEHVKSPQARITRPRQVYVGD

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=337, Percent_Identity=28.486646884273, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1786939, Length=412, Percent_Identity=43.4466019417476, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1786527, Length=367, Percent_Identity=29.4277929155313, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17555174, Length=391, Percent_Identity=26.5984654731458, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319850, Length=365, Percent_Identity=26.8493150684932, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=352, Percent_Identity=27.5568181818182, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=346, Percent_Identity=28.6127167630058, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356863, Length=403, Percent_Identity=28.287841191067, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640124, Length=345, Percent_Identity=27.2463768115942, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24640126, Length=345, Percent_Identity=27.536231884058, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48351; Mature: 48220

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLVNNENNERYEFETIESTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYVN
CEEEEEECCCCCEEEEEEHHCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCHHHHHHHCC
GKKGELYYRGHRIEDLVAKYKYVDVCKLLLTGELPKNQDESLEFELELRHRSFVHESLLN
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
MFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTMARRIVAKIPTLAAICYRNE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHSQ
CCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEHHHHHHHHEEECCCCC
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARV
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHHHHH
KDKNDNFKLMGFGHRVYKSYDPRAKILKGLKDELHQKGVKMDERLSEIAAKVEEIALKDE
CCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
YFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKSPQARITRPR
HHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCCCC
QVYVGD
EEEECC
>Mature Secondary Structure 
SVTLVNNENNERYEFETIESTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYVN
EEEEEECCCCCEEEEEEHHCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCHHHHHHHCC
GKKGELYYRGHRIEDLVAKYKYVDVCKLLLTGELPKNQDESLEFELELRHRSFVHESLLN
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
MFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTMARRIVAKIPTLAAICYRNE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHSQ
CCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEHHHHHHHHEEECCCCC
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARV
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHHHHH
KDKNDNFKLMGFGHRVYKSYDPRAKILKGLKDELHQKGVKMDERLSEIAAKVEEIALKDE
CCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
YFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKSPQARITRPR
HHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCCCC
QVYVGD
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]