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The map label for this gene is groEL

Identifier: 15644643

GI number: 15644643

Start: 7603

End: 9243

Strand: Reverse

Name: groEL

Synonym: HP0010

Alternate gene names: 15644643

Gene position: 9243-7603 (Counterclockwise)

Preceding gene: 15644644

Following gene: 15646197

Centisome position: 0.55

GC content: 45.28

Gene sequence:

>1641_bases
ATGGCAAAAGAAATCAAATTTTCAGATAGCGCGAGAAACCTTTTATTTGAAGGCGTGAGACAACTCCATGACGCTGTTAA
AGTAACCATGGGGCCAAGAGGCAGGAACGTGTTGATCCAAAAAAGCTATGGCGCTCCAAGCATCACTAAAGATGGCGTGA
GCGTGGCTAAAGAGATTGAATTAAGTTGCCCGGTAGCTAACATGGGCGCTCAACTCGTTAAAGAAGTAGCGAGCAAAACC
GCTGATGCTGCCGGCGATGGCACGACCACAGCGACCGTGCTGGCTTATAGCATTTTTAAAGAAGGTTTGAGGAACATCAC
GGCTGGGGCTAACCCTATTGAAGTGAAACGAGGCATGGATAAAGCCGCTGAAGCCATTATTAATGAGCTTAAAAAAGCGA
GCAAAAAAGTGGGCGGTAAAGAAGAAATCACCCAAGTGGCGACCATTTCTGCAAACTCCGATCACAATATCGGGAAACTC
ATCGCTGACGCTATGGAAAAAGTGGGTAAAGACGGCGTGATCACCGTTGAAGAAGCTAAGGGCATTGAAGATGAACTAGA
TGTTGTAGAAGGCATGCAATTTGATAGAGGCTACCTCTCCCCTTATTTTGTAACAAACGCTGAGAAAATGACCGCTCAAT
TGGATAACGCTTACATCCTTTTAACGGATAAAAAAATCTCTAGCATGAAAGACATTCTCCCGCTACTAGAAAAAACCATG
AAAGAGGGCAAACCGCTTTTAATCATCGCTGAAGACATTGAGGGCGAAGCTTTAACGACTCTAGTGGTGAATAAATTAAG
AGGCGTGTTGAATATCGCAGCGGTTAAAGCTCCAGGCTTTGGGGACAGAAGAAAAGAAATGCTCAAAGACATCGCTATTT
TAACCGGCGGTCAAGTTATTAGCGAAGAATTGGGCTTGAGTCTAGAAAACGCTGAAGTGGAGTTTTTAGGCAAAGCCGGA
AGGATTGTGATTGACAAAGACAACACCACGATCGTAGATGGCAAAGGCCATAGCCATGATGTCAAAGACAGAGTCGCGCA
AATCAAAACCCAAATTGCAAGCACGACAAGCGATTATGACAAAGAAAAATTGCAAGAAAGGTTGGCTAAACTCTCTGGCG
GTGTGGCTGTGATTAAAGTGGGCGCTGCGAGTGAAGTGGAAATGAAAGAGAAAAAAGACCGGGTTGATGATGCGTTGAGC
GCGACTAAAGCGGCTGTTGAAGAAGGTATTGTGATTGGCGGCGGTGCGGCTCTCATTCGCGCGGCTCAAAAAGTGCATTT
GAATTTGCACGATGATGAAAAAGTGGGCTATGAAATCATCATGCGCGCCATTAAAGCCCCATTAGCTCAAATCGCTATCA
ATGCCGGTTATGATGGCGGTGTGGTCGTGAATGAAGTAGAAAAACACGAAGGGCATTTTGGTTTTAACGCTAGCAATGGC
AAGTATGTGGATATGTTTAAAGAAGGCATTATTGACCCCTTAAAAGTAGAAAGGATCGCTTTACAAAATGCGGTTTCGGT
TTCAAGCCTGCTTTTAACCACAGAAGCCACCGTGCATGAAATCAAAGAAGAAAAAGCGGCCCCAGCAATGCCTGATATGG
GTGGCATGGGCGGTATGGGAGGCATGGGTGGCATGATGTAA

Upstream 100 bases:

>100_bases
TTGTCATACAGGTAATCATGACCATAAACATGCTAAAGAGCATGAAGCTTGCTGTCATGATCACAAAAAACACTAAAAAC
ATTATTATTAAGGATACAAA

Downstream 100 bases:

>100_bases
GCCCCCTTGCTTTTTAGTATCATCTGCTTTTAAAATCCCCTAAAATCCCCCCTTTCTAAAATCTCTTTTTTTGGGGGGTG
CTTTTTATTTGACAAAACCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKT
ADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKL
IADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAG
RIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALS
ATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNG
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM

Sequences:

>Translated_546_residues
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKT
ADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKL
IADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAG
RIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALS
ATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNG
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM
>Mature_545_residues
AKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKTA
DAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLI
ADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTMK
EGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVISEELGLSLENAEVEFLGKAGR
IVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSA
TKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNGK
YVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=53.2075471698113, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=53.2075471698113, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI38455427, Length=569, Percent_Identity=23.1985940246046, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=60.6060606060606, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.7958412098299, Blast_Score=526, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=50.7177033492823, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17564182, Length=556, Percent_Identity=22.1223021582734, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532603, Length=558, Percent_Identity=24.3727598566308, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32566944, Length=124, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=52.6819923371648, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6322350, Length=562, Percent_Identity=24.7330960854093, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=123, Percent_Identity=30.0813008130081, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=54.1825095057034, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=54.1825095057034, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.0436432637571, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.0436432637571, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.0436432637571, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=539, Percent_Identity=43.4137291280148, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=35.2611940298507, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=35.2611940298507, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24583944, Length=546, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58265; Mature: 58134

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
LSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMD
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
KAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEHHHC
GIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHH
SEELGLSLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYD
HHHHCCEECCCCEEEECCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCH
KEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIR
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
AAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNG
HHHHHEEECCCCHHHHHHHHHHHHHCCHHHHEEECCCCCCEEEEHHHHCCCCCCCCCCCC
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMG
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMGGMM
CCCCCC
>Mature Secondary Structure 
AKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
LSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMD
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
KAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEHHHC
GIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAILTGGQVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHH
SEELGLSLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYD
HHHHCCEECCCCEEEECCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCH
KEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIR
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
AAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNG
HHHHHEEECCCCHHHHHHHHHHHHHCCHHHHEEECCCCCCEEEEHHHHCCCCCCCCCCCC
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMG
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMGGMM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA