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The map label for this gene is bioF_2

Identifier: 15618951

GI number: 15618951

Start: 1196569

End: 1197717

Strand: Reverse

Name: bioF_2

Synonym: CPn1043

Alternate gene names: 15618951

Gene position: 1197717-1196569 (Counterclockwise)

Preceding gene: 15618952

Following gene: 15618950

Centisome position: 97.36

GC content: 41.95

Gene sequence:

>1149_bases
ATGTTATGCCAACAATTCCTAATTGAGGCTTTGGCAAGACGTAAGTCCAAACATACCTACCGCTCGCTAAGCTTAAACTC
TCATCTCATTGATTTTACCTCTAATGATTATCTTGGATTTGCCTCTTCTCCAGAATTAAGGAAAGAATACATTACCAAGC
TCCATGCGATAGAATCGCTTGGAGCTACAGGGTCTCGGCTTCTCACAGGGCACTCGCAACTCTGTCAGCGTATAGAAGAA
CAACTAGCCGCTTATCATAATTTTGAAAGCTGTTTGATCTTCAATACAGGTTACACAGCAAACTTAGGCTTGCTCTATGC
TCTTGCCACCGACCAGGATCGTATTCTTCACGACCTTTATATCCATGCTTCTATTTATGATGGCATCCGATTAAGCAAAG
CTCAAAGCTTTCCCTTTAATCACAATGATCTGAATCACTTAGAAAAACGTTTAGCAAGCTCCCATCTAGGAAGAACCTTT
GTTTGCGTGGAATCCGTATACTCGCTTCATGGCTCCGTGGCTCCTTTACAAGCTATCAGTGAACTCTGTGAAAGATATTC
CGCTTACCTGATCGTTGACGAAGCCCATGCAGTCGGAGTTTTTGGAGATCAGGGCGAAGGCCTTGTCTCTGCATTAGGTC
TTCAAGATAAAGTCCTAGCCACCGTCTATACTTTTGGAAAAGCTCTAGGCACTCATGGCGCTGCTATTGCAGGAAGTTCT
ATACTCAAAGACTACCTAATTAATTTTTGTAGACCTTTCATATACACCACAGCCCAACCTCCCCATGCGCTCACAGCTAT
AGAGCTCGCTTATGAGCATAACCAACGTGCTTTTAATCAACGTGAACATCTTTCTGCTCTCATTCATCATTTTCGCGAAA
AAGCTCAAAACTTGGGACTTCAGCTAATGAAAGACAATACTACTACACCTATACAATCTATTTGTGTTTCAGGGAGCCAT
CGTGCTCGGCAAGCCGCATTGCAAATACAAAACTCAGGGTACGATGTTCGCCCTATCGTGAGCCCAACAGTAAAACAAAG
AGAAGAACTGTTACGTATTTGCCTTCATGCCTTCAATACAAAAAATGAAATAGATCACCTTTTACATACTTTAGAGCAAA
TTTTTTTATGCAACGTATCATCATTGTAG

Upstream 100 bases:

>100_bases
TGTTGACTGTAGAAAACAATGATATAGATGAAGATGCTGAAATGATCAAACTTTTAGGCTTAATCCCTCGCCCTTCATTT
GGAATAGAAAGAGGTAACCC

Downstream 100 bases:

>100_bases
GAATCGACACTGGCGTAGGAAAAACCATTGTCAGTGCTATCCTTGCTAGAGCACTTAACGCAGAATACTGGAAACCTATA
CAAGCAGGGAATCTAGAAAA

Product: oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MLCQQFLIEALARRKSKHTYRSLSLNSHLIDFTSNDYLGFASSPELRKEYITKLHAIESLGATGSRLLTGHSQLCQRIEE
QLAAYHNFESCLIFNTGYTANLGLLYALATDQDRILHDLYIHASIYDGIRLSKAQSFPFNHNDLNHLEKRLASSHLGRTF
VCVESVYSLHGSVAPLQAISELCERYSAYLIVDEAHAVGVFGDQGEGLVSALGLQDKVLATVYTFGKALGTHGAAIAGSS
ILKDYLINFCRPFIYTTAQPPHALTAIELAYEHNQRAFNQREHLSALIHHFREKAQNLGLQLMKDNTTTPIQSICVSGSH
RARQAALQIQNSGYDVRPIVSPTVKQREELLRICLHAFNTKNEIDHLLHTLEQIFLCNVSSL

Sequences:

>Translated_382_residues
MLCQQFLIEALARRKSKHTYRSLSLNSHLIDFTSNDYLGFASSPELRKEYITKLHAIESLGATGSRLLTGHSQLCQRIEE
QLAAYHNFESCLIFNTGYTANLGLLYALATDQDRILHDLYIHASIYDGIRLSKAQSFPFNHNDLNHLEKRLASSHLGRTF
VCVESVYSLHGSVAPLQAISELCERYSAYLIVDEAHAVGVFGDQGEGLVSALGLQDKVLATVYTFGKALGTHGAAIAGSS
ILKDYLINFCRPFIYTTAQPPHALTAIELAYEHNQRAFNQREHLSALIHHFREKAQNLGLQLMKDNTTTPIQSICVSGSH
RARQAALQIQNSGYDVRPIVSPTVKQREELLRICLHAFNTKNEIDHLLHTLEQIFLCNVSSL
>Mature_382_residues
MLCQQFLIEALARRKSKHTYRSLSLNSHLIDFTSNDYLGFASSPELRKEYITKLHAIESLGATGSRLLTGHSQLCQRIEE
QLAAYHNFESCLIFNTGYTANLGLLYALATDQDRILHDLYIHASIYDGIRLSKAQSFPFNHNDLNHLEKRLASSHLGRTF
VCVESVYSLHGSVAPLQAISELCERYSAYLIVDEAHAVGVFGDQGEGLVSALGLQDKVLATVYTFGKALGTHGAAIAGSS
ILKDYLINFCRPFIYTTAQPPHALTAIELAYEHNQRAFNQREHLSALIHHFREKAQNLGLQLMKDNTTTPIQSICVSGSH
RARQAALQIQNSGYDVRPIVSPTVKQREELLRICLHAFNTKNEIDHLLHTLEQIFLCNVSSL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=356, Percent_Identity=29.7752808988764, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI7657118, Length=365, Percent_Identity=29.041095890411, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI83977440, Length=398, Percent_Identity=29.8994974874372, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI83977444, Length=380, Percent_Identity=31.0526315789474, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI83977442, Length=398, Percent_Identity=29.8994974874372, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4502025, Length=395, Percent_Identity=28.3544303797468, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI40316939, Length=395, Percent_Identity=28.3544303797468, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=26.1707988980716, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI119220554, Length=363, Percent_Identity=25.8953168044077, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI5454084, Length=255, Percent_Identity=22.3529411764706, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=34.3023255813954, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1790046, Length=358, Percent_Identity=27.0949720670391, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=29.8591549295775, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17560914, Length=370, Percent_Identity=26.7567567567568, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=370, Percent_Identity=26.7567567567568, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32566772, Length=397, Percent_Identity=24.1813602015113, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982617, Length=223, Percent_Identity=24.2152466367713, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982625, Length=223, Percent_Identity=24.2152466367713, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320438, Length=370, Percent_Identity=28.6486486486486, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320267, Length=372, Percent_Identity=26.8817204301075, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323954, Length=229, Percent_Identity=25.764192139738, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24662918, Length=353, Percent_Identity=29.4617563739377, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17137420, Length=404, Percent_Identity=28.7128712871287, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI17136286, Length=384, Percent_Identity=25.5208333333333, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=22.7436823104693, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=22.7436823104693, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=22.7436823104693, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42718; Mature: 42718

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCQQFLIEALARRKSKHTYRSLSLNSHLIDFTSNDYLGFASSPELRKEYITKLHAIESL
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
GATGSRLLTGHSQLCQRIEEQLAAYHNFESCLIFNTGYTANLGLLYALATDQDRILHDLY
CCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHH
IHASIYDGIRLSKAQSFPFNHNDLNHLEKRLASSHLGRTFVCVESVYSLHGSVAPLQAIS
HHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
ELCERYSAYLIVDEAHAVGVFGDQGEGLVSALGLQDKVLATVYTFGKALGTHGAAIAGSS
HHHHHCCEEEEEECCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHH
ILKDYLINFCRPFIYTTAQPPHALTAIELAYEHNQRAFNQREHLSALIHHFREKAQNLGL
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
QLMKDNTTTPIQSICVSGSHRARQAALQIQNSGYDVRPIVSPTVKQREELLRICLHAFNT
EEEECCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
KNEIDHLLHTLEQIFLCNVSSL
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLCQQFLIEALARRKSKHTYRSLSLNSHLIDFTSNDYLGFASSPELRKEYITKLHAIESL
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
GATGSRLLTGHSQLCQRIEEQLAAYHNFESCLIFNTGYTANLGLLYALATDQDRILHDLY
CCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHHH
IHASIYDGIRLSKAQSFPFNHNDLNHLEKRLASSHLGRTFVCVESVYSLHGSVAPLQAIS
HHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
ELCERYSAYLIVDEAHAVGVFGDQGEGLVSALGLQDKVLATVYTFGKALGTHGAAIAGSS
HHHHHCCEEEEEECCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHH
ILKDYLINFCRPFIYTTAQPPHALTAIELAYEHNQRAFNQREHLSALIHHFREKAQNLGL
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
QLMKDNTTTPIQSICVSGSHRARQAALQIQNSGYDVRPIVSPTVKQREELLRICLHAFNT
EEEECCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
KNEIDHLLHTLEQIFLCNVSSL
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA