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The map label for this gene is bioA

Identifier: 15618949

GI number: 15618949

Start: 1194723

End: 1195994

Strand: Reverse

Name: bioA

Synonym: CPn1041

Alternate gene names: 15618949

Gene position: 1195994-1194723 (Counterclockwise)

Preceding gene: 15618950

Following gene: 15618948

Centisome position: 97.22

GC content: 44.65

Gene sequence:

>1272_bases
ATGGACAAGCAATCATCAGGGAATTCAGGGTGTATCTGGCACCCCTTCACTCAATCTGCATTAGATTCTACACCCATAAA
GATTGTAAGGGGAGAAGGTGCTTACCTCTATGCGGAATCAGGAACAAGATATCTTGATGCGATATCTTCATGGTGGTGCA
ACCTCCACGGTCATGGGCATCCCTACATTACAAAAAAATTATGTGAGCAAGCACAGAAGTTAGAACATGTGATCTTCGCA
AATTTCACCCATGAACCGGCTCTAGAGCTCGTATCGAAACTCGCTCCCCTCCTTCCTGAAGGTCTAGAACGTTTCTTTTT
CTCTGACAACGGATCAACGTCTATCGAAATAGCAATGAAAATTGCTGTGCAATATTACTACAATCAAAACAAGGCTAAGA
GCCATTTTGTTGGACTCAGCAATGCCTATCACGGAGATACATTTGGAGCTATGTCGATAGCTGGCACGAGCCCTACTACA
GTTCCCTTTCATGATCTTTTTCTTCCTTCCAGTACAATTGCTGCTCCCTATTATGGCAAGGAAGAGCTTGCCATTGCCCA
AGCAAAAACAGTCTTTTCTGAAAGCAATATCGCAGCGTTTATCTATGAGCCGCTATTGCAAGGTGCTGGAGGGATGTTAA
TGTATAATCCCGAAGGCCTAAAGGAGATTCTCAAGCTTGCCAAGCATTACGGGGTTCTCTGTATTGCTGATGAAATTCTT
ACTGGCTTTGGCCGTACGGGTCCACTGTTTGCTTCTGAATTTACAGACATTCCTCCTGACATTATCTGTCTTTCTAAAGG
TCTTACAGGAGGCTATCTCCCTCTAGCCTTGACAGTAACCACTAAAGAAATTCATGATGCCTTTGTCTCCCAAGATCGGA
TGAAGGCACTGCTTCATGGCCATACCTTCACAGGAAATCCTTTAGGCTGTAGTGCTGCCCTCGCTTCTTTGGATCTCACC
CTATCTCCAGAATGCCTACAACAAAGGCAAATGATAGAACGGTGTCATCAAGAGTTTCAAGAAGCTCATGGTTCCCTATG
GCAACGGTGTGAGGTTCTGGGCACGGTACTCGCTCTAGATTACCCTGCAGAAGCTACAGGATATTTTTCACAATATAGAG
ACCATCTCAATCGCTTTTTCTTAGAACGTGGAGTCCTTCTTCGTCCTTTAGGGAACACACTGTATGTGCTGCCCCCCTAC
TGTATCCAAGAAGAAGATCTCCGGATTATTTATTCTCACCTACAGGATGCCCTATGTCTACAACCACAGTAA

Upstream 100 bases:

>100_bases
TAACTCAAGAAATCAAGCTTCCTATAATCGGGACTCTTGCCAAGGAAAAAGAAATCACAAAGACAATCATAAGCTGTTAT
GCCGAACAATGGAAGGAAGT

Downstream 100 bases:

>100_bases
AACACTTTATCCACACAGCCTCTCGTTGGGAGCCCGTTCTCAAAGAGATCGTAGCTTCCAACTATTGGCATGCACAATGG
ATAAATACCCTGTCCTTTTT

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDKQSSGNSGCIWHPFTQSALDSTPIKIVRGEGAYLYAESGTRYLDAISSWWCNLHGHGHPYITKKLCEQAQKLEHVIFA
NFTHEPALELVSKLAPLLPEGLERFFFSDNGSTSIEIAMKIAVQYYYNQNKAKSHFVGLSNAYHGDTFGAMSIAGTSPTT
VPFHDLFLPSSTIAAPYYGKEELAIAQAKTVFSESNIAAFIYEPLLQGAGGMLMYNPEGLKEILKLAKHYGVLCIADEIL
TGFGRTGPLFASEFTDIPPDIICLSKGLTGGYLPLALTVTTKEIHDAFVSQDRMKALLHGHTFTGNPLGCSAALASLDLT
LSPECLQQRQMIERCHQEFQEAHGSLWQRCEVLGTVLALDYPAEATGYFSQYRDHLNRFFLERGVLLRPLGNTLYVLPPY
CIQEEDLRIIYSHLQDALCLQPQ

Sequences:

>Translated_423_residues
MDKQSSGNSGCIWHPFTQSALDSTPIKIVRGEGAYLYAESGTRYLDAISSWWCNLHGHGHPYITKKLCEQAQKLEHVIFA
NFTHEPALELVSKLAPLLPEGLERFFFSDNGSTSIEIAMKIAVQYYYNQNKAKSHFVGLSNAYHGDTFGAMSIAGTSPTT
VPFHDLFLPSSTIAAPYYGKEELAIAQAKTVFSESNIAAFIYEPLLQGAGGMLMYNPEGLKEILKLAKHYGVLCIADEIL
TGFGRTGPLFASEFTDIPPDIICLSKGLTGGYLPLALTVTTKEIHDAFVSQDRMKALLHGHTFTGNPLGCSAALASLDLT
LSPECLQQRQMIERCHQEFQEAHGSLWQRCEVLGTVLALDYPAEATGYFSQYRDHLNRFFLERGVLLRPLGNTLYVLPPY
CIQEEDLRIIYSHLQDALCLQPQ
>Mature_423_residues
MDKQSSGNSGCIWHPFTQSALDSTPIKIVRGEGAYLYAESGTRYLDAISSWWCNLHGHGHPYITKKLCEQAQKLEHVIFA
NFTHEPALELVSKLAPLLPEGLERFFFSDNGSTSIEIAMKIAVQYYYNQNKAKSHFVGLSNAYHGDTFGAMSIAGTSPTT
VPFHDLFLPSSTIAAPYYGKEELAIAQAKTVFSESNIAAFIYEPLLQGAGGMLMYNPEGLKEILKLAKHYGVLCIADEIL
TGFGRTGPLFASEFTDIPPDIICLSKGLTGGYLPLALTVTTKEIHDAFVSQDRMKALLHGHTFTGNPLGCSAALASLDLT
LSPECLQQRQMIERCHQEFQEAHGSLWQRCEVLGTVLALDYPAEATGYFSQYRDHLNRFFLERGVLLRPLGNTLYVLPPY
CIQEEDLRIIYSHLQDALCLQPQ

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=28.0459770114943, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI226442705, Length=434, Percent_Identity=27.4193548387097, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557809, Length=396, Percent_Identity=29.040404040404, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=28.9592760180996, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226442709, Length=400, Percent_Identity=26.75, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI24119277, Length=319, Percent_Identity=29.153605015674, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI284507298, Length=309, Percent_Identity=29.126213592233, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=38.2775119617225, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=29.156010230179, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=30.126582278481, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1789759, Length=386, Percent_Identity=29.2746113989637, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=26.8948655256724, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787560, Length=431, Percent_Identity=28.0742459396752, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786349, Length=400, Percent_Identity=24.5, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=315, Percent_Identity=29.2063492063492, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=424, Percent_Identity=29.2452830188679, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=194, Percent_Identity=31.9587628865979, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=23.5565819861432, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=33.3333333333333, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323470, Length=402, Percent_Identity=27.8606965174129, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=391, Percent_Identity=28.1329923273657, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357415, Length=400, Percent_Identity=28, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356575, Length=420, Percent_Identity=28.0952380952381, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI161085790, Length=441, Percent_Identity=28.7981859410431, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=29.0023201856148, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46913; Mature: 46913

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQSSGNSGCIWHPFTQSALDSTPIKIVRGEGAYLYAESGTRYLDAISSWWCNLHGHGH
CCCCCCCCCCEEECCCCHHHCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHEECCCCCC
PYITKKLCEQAQKLEHVIFANFTHEPALELVSKLAPLLPEGLERFFFSDNGSTSIEIAMK
CHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEHE
IAVQYYYNQNKAKSHFVGLSNAYHGDTFGAMSIAGTSPTTVPFHDLFLPSSTIAAPYYGK
EHHHHHHCCCCCHHHEEECCCCCCCCCCCCEEECCCCCCCCCHHHHCCCCCCCCCCCCCC
EELAIAQAKTVFSESNIAAFIYEPLLQGAGGMLMYNPEGLKEILKLAKHYGVLCIADEIL
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEHHHHH
TGFGRTGPLFASEFTDIPPDIICLSKGLTGGYLPLALTVTTKEIHDAFVSQDRMKALLHG
HCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCC
HTFTGNPLGCSAALASLDLTLSPECLQQRQMIERCHQEFQEAHGSLWQRCEVLGTVLALD
CCCCCCCCCHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YPAEATGYFSQYRDHLNRFFLERGVLLRPLGNTLYVLPPYCIQEEDLRIIYSHLQDALCL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHCC
QPQ
CCC
>Mature Secondary Structure
MDKQSSGNSGCIWHPFTQSALDSTPIKIVRGEGAYLYAESGTRYLDAISSWWCNLHGHGH
CCCCCCCCCCEEECCCCHHHCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHEECCCCCC
PYITKKLCEQAQKLEHVIFANFTHEPALELVSKLAPLLPEGLERFFFSDNGSTSIEIAMK
CHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEHE
IAVQYYYNQNKAKSHFVGLSNAYHGDTFGAMSIAGTSPTTVPFHDLFLPSSTIAAPYYGK
EHHHHHHCCCCCHHHEEECCCCCCCCCCCCEEECCCCCCCCCHHHHCCCCCCCCCCCCCC
EELAIAQAKTVFSESNIAAFIYEPLLQGAGGMLMYNPEGLKEILKLAKHYGVLCIADEIL
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEHHHHH
TGFGRTGPLFASEFTDIPPDIICLSKGLTGGYLPLALTVTTKEIHDAFVSQDRMKALLHG
HCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCC
HTFTGNPLGCSAALASLDLTLSPECLQQRQMIERCHQEFQEAHGSLWQRCEVLGTVLALD
CCCCCCCCCHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YPAEATGYFSQYRDHLNRFFLERGVLLRPLGNTLYVLPPYCIQEEDLRIIYSHLQDALCL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHCC
QPQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]